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I read this to say that it costs too much to investigate fraudulent science, so go ahead and do it... am I missing the point?
Yeah, I think so, I read it as they are having to invest a lot of money to be proactive about educating researchers and trying to prevent it from happening, but it's well worth the cost since it will ultimately be less than the cost associated with instances of fraud.
How do you prevent someone from making up something on purpose to get it accepted for publication though? My understand of this article was that it wasn't cost effective to do that, and therefore we are missing on potentially made up results!
So these dudes just wrote a paper to state the existence of a problem (which we knew), that investigating this problem is expensive (which we knew), and that we have no good answer to it (which we knew). What a waste of space. You are never going to catch all the crooks and cheats. Peer review, stringent standards for publication, and others trying to reproduce the data are the best known answers to this problem.
The point of the paper was to assess the direct costs of scientific misconduct. It's actually written by some of the chief chickenheads at Roswell Park Cancer Center and provides an interesting view of how scientific misconduct cases are handled. They seem to want to make the case that there are many 'sins of omission' and little smudges made to massage data that constitute misconduct, either consciously or unconsciously, but these investigations can be just as costly as blatantly making crap up.
By the way, here's the link to the paper. It's worth a read if you're interested in how misconduct investigations are run.