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I've never really thought about the shape of the genome, but I can see how that would make a big difference.
This is really interesting, here's a link to the paper if anyone is interested in reading more http://nar.oxfordjournals.org/content/early/2010/10/27/nar.gkq955.abstract. I particularly like the technique they used, if they could apply it to human cells, I wonder if they could sort of create a kind of in vivo microarray, look at whether genes are upregulated or downregulated under different conditions. Very cool anyway!
What a wonderful article! You know, the 3-D confirmation of proteins have always been shown to be one of the most important aspects of its function. It is hard to believe that this idea had never been extrapolated to the human genome!
NMR studies in particular have really demonstrated how the distance between amino acids on opposite sides of a protein determine its substrate specificity and affinity.
Not sure that this will provide the same kind of insight as protein structure biology. Proteins require to be in their quarternary structure to function, therefore understanding the way it folds is the key to understanding the role of the protein. This is not the case for the genome.
Not necessarily though, isn't that kind of the point of the article, that in fact the shape of the genome might be just as important, maybe their are genomic structures we haven't elucidated yet.
Archaeologists unearthed the missing head of one of the two sphinxes found guarding the entrance of an ancient tomb in Greece's northeast, as the diggers made their way into the monument's inner chambers, the culture ministry said on Tuesday.
In what the medical community is calling an incredible breakthrough, a Polish man who was left a quadriplegic after a stabbing, can walk again. The miraculous procedure involved doctors taking cells from his nose and implanting them into his spinal cord.
In a new book, San Francisco-based photographer Susan Middleton captures the curious gestures and expressions of marine invertebrates
Lab at the University of Texas at San Antonio gets Pentagon funding to see if brain waves can direct drone movement
After a severe brain injury, some people remain in a vegetative or minimally conscious state, unable to speak or move intentionally, and apparently unaware of the world around them. But in recent years, neuroscientists have found signs that some of these patients may still be conscious, at least to a degree. Now researchers have used a branch of mathematics called graph theory to search for neural signatures of consciousness.
Few parasitoids are more bizarre or disturbing than the wasps of the genus Glyptapanteles, whose females inject their eggs into living caterpillars. Once inside, the larvae mature, feeding on the caterpillar’s body fluids before gnawing through its skin en masse and emerging into the light of day. And despite the trauma, not only does the caterpillar survive---initially at least---but the larvae proceed to mind-control it, turning their host into a bodyguard that protects them as they spin their cocoons and finish maturing. Then, finally, the caterpillar starves to death, but only after the tiny wasps emerge from their cocoons and fly away.
From their new book A History of Life in 100 Fossils, Paul Taylor and Aaron O'Dea share the story of 10 incredible fossils
We love origin stories. When we see successful groups of animals and plants, we wonder where they came …
First research of its kind shows that tasers could impair a person's memory and thought process
Sometimes the most fascinating animals are the ones that are no longer with us. The oddly named sthenurine is no exception.