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I've never really thought about the shape of the genome, but I can see how that would make a big difference.
This is really interesting, here's a link to the paper if anyone is interested in reading more http://nar.oxfordjournals.org/content/early/2010/10/27/nar.gkq955.abstract. I particularly like the technique they used, if they could apply it to human cells, I wonder if they could sort of create a kind of in vivo microarray, look at whether genes are upregulated or downregulated under different conditions. Very cool anyway!
What a wonderful article! You know, the 3-D confirmation of proteins have always been shown to be one of the most important aspects of its function. It is hard to believe that this idea had never been extrapolated to the human genome!
NMR studies in particular have really demonstrated how the distance between amino acids on opposite sides of a protein determine its substrate specificity and affinity.
Not sure that this will provide the same kind of insight as protein structure biology. Proteins require to be in their quarternary structure to function, therefore understanding the way it folds is the key to understanding the role of the protein. This is not the case for the genome.
Not necessarily though, isn't that kind of the point of the article, that in fact the shape of the genome might be just as important, maybe their are genomic structures we haven't elucidated yet.
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In the article on the discovery of dinosaurs (They’re back, Review, 6 June) you state: “In Sussex, a local doctor uncovered fragmentary remains of what appeared to be two more species of colossal extinct land reptiles.” You grossly underplay the contribution of Lewes-born Gideon Mantell, geologist and palaeontologist, author and diarist, friend to princes and international scholars as well as local doctor. Mantell not only discovered (aided by his wife) the first remains of the iguanodon in 1824 but named it – as it resembled the tooth of an iguana. This was the first known land dinosaur, Mary Anning having identified the first sea-living dinosaur.Mantell went on to put together more pieces of the jigsaw with extra fossil discoveries. In contrast to Richard Owen, whose models form the basis for the Crystal Palace dinosaurs, Mantell stated correctly that iguanodon would have walked on their back legs, using their forearms to fight or gather food. He did, however, attribute the thumb spike to a nose horn though later corrected this assumption. The Natural History Museum has a display on Gideon and his wife Mary’s contribution as well as the large “Mantell-piece” of Iguanodon fossils that he had on show in his museum in Brighton. He sold it, along with many more priceless items, to the British Museum in 1838. Gideon Mantell’s reputation deserves better than your throwaway remark. Debby MatthewsLewes, East Sussex Continue reading...
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