Thanks to The Wistar Institute for this article.
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I've never really thought about the shape of the genome, but I can see how that would make a big difference.
This is really interesting, here's a link to the paper if anyone is interested in reading more http://nar.oxfordjournals.org/content/early/2010/10/27/nar.gkq955.abstract. I particularly like the technique they used, if they could apply it to human cells, I wonder if they could sort of create a kind of in vivo microarray, look at whether genes are upregulated or downregulated under different conditions. Very cool anyway!
What a wonderful article! You know, the 3-D confirmation of proteins have always been shown to be one of the most important aspects of its function. It is hard to believe that this idea had never been extrapolated to the human genome!
NMR studies in particular have really demonstrated how the distance between amino acids on opposite sides of a protein determine its substrate specificity and affinity.
Not sure that this will provide the same kind of insight as protein structure biology. Proteins require to be in their quarternary structure to function, therefore understanding the way it folds is the key to understanding the role of the protein. This is not the case for the genome.
Not necessarily though, isn't that kind of the point of the article, that in fact the shape of the genome might be just as important, maybe their are genomic structures we haven't elucidated yet.
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