Women who take commonly prescribed drugs for osteoporosis known as bisphosphonates for five years or more may be at higher risk of certain kinds of fractures of their thigh bone, a new study has found.
However, the drugs do prevent hip fractures. And, since the overall risk of thigh bone fractures caused by the drugs is low, women at high risk for hip and other osteoporosis-related fractures should not stop taking bisphosphonates, according to researchers at St. Michael's Hospital and the Institute for Clinical Evaluative Sciences.
The study was published today in the Journal of the American Medical Association (JAMA).
Typical hip fractures caused by osteoporosis occur in the upper part of the femur close to the hip joint and are an important cause of disability, need for long-term care and even death in the elderly. The risk of these kinds of fractures is reduced by bisphosphonate treatment, which was confirmed by this study.
But the study found that less common fractures lower down from the hip and closer to the middle of the femur –sometimes called "atypical" or "unusual" fractures -- occurred more than 2.5 times as often in women who had taken bisphosphonates for more than five years than short-term users of the drug..
"Prolonged use of bisphosphonates is associated with rare and unusual fractures of the femur," said the lead author, Laura Park-Wyllie, a pharmaceutical safety and outcomes researcher at St. Michael's. "But the proven benefit of these drugs for the much more common fractures of osteoporosis usually outweighs the harm, especially in the initial years of treatment for osteoporosis. Women with osteoporosis, at high risk for osteoporotic fractures, should not stop taking bisphosphonate therapy because of the small risk of these thigh fractures."
Park-Wyllie said the study was prompted by an increasing number of reports of thigh bone fractures among older women who have taken the drugs sold as Fosamax, Actonel or Didrocal for five years or more and by conflicting findings from small, observational studies.
The St. Michael's-ICES study is the largest assessment of the issue to date. The researchers identified 205,466 women over age 68 who had been prescribed bisphosphonates between 2002 and 2008.
Of those, 716 women (0.35 per cent) had a fracture of the femur. These women were compared to other women of similar ages who had also been prescribed the drugs but who did not have femur fractures.
"Our study estimated that the risk of fractures to the femur was 0.13 per cent for women entering their sixth year on the drug – or just over one in 1,000," Park-Wyllie said. "Use of bisphosphonates for less than five years was not associated with a significant risk of thigh fractures."
About 50 per cent of women over 50 will suffer an osteoporosis-related fracture. The most common involve the wrist and the spine, but hip fractures can have some of the most severe consequences, with one in five of those women expected to die within 12 months.
St. Michael's Hospital: http://www.stmichaelshospital.com/
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
European Medicines Agency recommends RTS,S, or Mosquirix, developed by GSK and backed by Gates Foundation, for use in young children in Africa
Drought conditions in western states may be fueling the spread of this potentially deadly illness
Terminal cancer patients sometimes get chemotherapy in the belief that it will ease their symptoms. But a study finds many who get the treatment near death actually have a poorer quality of life.
NPR's Geoff Brumfiel reports that the samples of anthrax the Pentagon thought were dead, were still alive. The Pentagon says the public was never at risk.
Yes, health officials in Florida have reported nine cases of leprosy so far this year. And yes, armadillos can transmit leprosy. But scientists say we needn't fear the armored mammals.
First case of long-term remission gives scientists new insights into the potential effectiveness of early HIV detection and treatment
Manufacturing and wastewater treatment sites are releasing bisphenol A into the air, exposing people to high levels of the chemical, according to a study
The sheer volume at sporting events and concerts, and on headphones, can damage our ears in ways standard tests can't detect. How can you safeguard your hearing?
To better target its efforts, the agency is identifying problem areas, where people are facing undue environmental risks
It’s been almost a month since a case of avian influenza was detected in poultry in the central …