Recent research found that microneedle vaccine patches are more effective at delivering protection against influenza virus in mice than subcutaneous or intramuscular inoculation. A new, detailed analysis of the early immune responses by the Emory and Georgia Tech research team helps explain why the skin is such fertile ground for vaccination with these tiny, virtually painless microneedles.
The research was published in the January/February issue of the online journal mBio.
The skin, in contrast to the muscles, contains a rich network of antigen-presenting cells, which are immune signaling cells that are essential to initiating an immune response. The researchers found that microneedle skin immunization with inactivated influenza virus resulted in a local increase of cytokines important for recruitment of neutrophils, monocytes and dendritic cells at the site of immunization. All these cells play a role in activating a strong innate immune response against the virus.
Microneedle vaccination also may lead to prolonged depositing of antigen – the viral molecules that are the targets of antibody responses. Such a prolonged antigen release could allow more efficient uptake by antigen-presenting cells. In addition, activated and matured dendritic cells carrying influenza antigen were found to migrate from the skin– an important feature of activating the adaptive immune response.
The research was led by first author Maria del Pilar Martin, PhD and Richard W. Compans, PhD, Emory professor of microbiology and immunology. Other authors included William C. Weldon, Dimitrios G. Koutsonanos, Hamed Akbari, Ioanna Skountzou, and Joshy Jacob from Emory University and Vladimir G. Zarnitsyn and Mark R. Prausnitz from Georgia Tech.
"Our research reveals new details of the complex but efficient immune response to influenza virus provided by microneedle skin patches," says Compans. "Despite the success of vaccination against influenza, the virus has many subtypes, mutates rapidly and continues to elude complete and long-term protection, and therefore requires annual vaccination with an updated vaccine each year.
"New vaccine formulations and delivery methods such as vaccine-coated microneedle patches could provide an improved protective response, which would be of particular benefit to those at high risk of related complications. Vaccine delivery to the skin by microneedles is painless, and offers other advantages such as eliminating potential risks due to use of hypodermic needles."
Emory University: http://www.emory.edu
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
The health of infants is being put at risk as anti-vaccine groups discourage uptake of vitamin K for newborns, says Amanda Marcott
The lead in human teeth holds clues about where a person grew up and can help criminal investigators and archaeologists working with old or decomposed corpses, according to a University of Florida researcher.
West African countries are trying to contain the deadly disease
The Great War helped create the influenza pandemic of 1918, which eventually brought an early end to the Great War.
In 1986, a two-and-a-half year-old girl named Michelle Funk fell into a stream and drowned. By the time paramedics found her, she hadn’t been breathing for more than an hour. Her heart was stopped. In other words, she was dead.
Political unrest in Pakistan has been a gift to the poliovirus, with 99 cases reported there so far this year. But Rotary International, which has already vaccinated 2 billion children in 122 countries, is hitting back hard
UK scientists model the physical attributes that underpin our social judgements about strangers.
A new study suggests that using media technology may be the wrong way to try to unwind at the end of a hard day
Arizona death row inmate Joseph Wood took almost 2 hours to die – why is a drug combination is being experimented with in the death chamber?
Scientists have discovered what may be the most common virus in people worldwide. The tiny critter doesn't make us sick but may be involved in obesity and diabetes.