Researchers at King's College London have for the first time identified a gene linked to age-related degeneration of the intervertebral discs in the spine, a common cause of lower back pain.
Costing the UK an estimated £7billion a year due to sickness leave and treatment costs, the causes of back pain are not yet fully understood. Until now, the genetic cause of lower back pain associated with lumbar disc degeneration (LDD) was unknown, but the largest study to date, published this week in the journal Annals of Rheumatic Diseases, has revealed an association with the PARK2 gene.
The researchers, funded by the Wellcome Trust and Arthritis Research UK, say more research into this surprising association needs to be carried out in order to fully understand how it is triggered, but this new finding could ultimately pave the way towards developing new treatments in the future.
LDD is a common age-related trait, with over a third of middle-aged women having at least one degenerate disc in the spine. Discs become dehydrated, lose height and the vertebrae next to the discs develop bony growths called osteophytes. These changes can cause or contribute to lower back pain. LDD is inherited in between 65 – 80 per cent of people with the condition, suggesting that genes play a key role.
Scientists compared MRI images of the spine in 4,600 individuals with genome-wide association data, which mapped the genes of all the volunteers. They identified that the gene PARK2 was implicated in people with degenerate discs and could affect the speed at which they deteriorate.
The researchers say the results show that the gene may be switched off in people with LDD. Although it is still unclear how this might happen, it is thought that environmental factors, such as lifestyle and diet, could trigger this switch by making changes known as epigenetic modifications to the gene.
Dr Frances Williams, Senior Lecturer from the Department of Twin Research and Genetic Epidemiology at King's College London, said: "Back pain can have a serious impact on people's lives and is one of the most common causes of sickness leave, costing both the NHS and UK economy billions each year.
"We have performed, using data collected from around the world, the biggest genome-wide association analysis of lumbar disc degeneration (LDD). We know that people whose discs wear out are at increased risk of episodes of lower back pain, but normal human discs are hard to get hold of to study so until now our knowledge of normal human biology was incomplete.
"We have identified a gene called PARK2 as associated with LDD. We have shown that the gene may be switched off in people with the condition.
"Further work by disc researchers to define the role of this gene will, we hope, shed light on one of most important causes of lower back pain. It is feasible that if we can build on this finding and improve our knowledge of the condition, we may one day be able to develop new, more effective treatments for back pain caused by this common condition."
King's College London: http://www.kcl.ac.uk
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
From flying frogs to deep-sea squid, meet some of the other nosferatu of the animal kingdom
After 50 years of cutting-edge seafloor exploration, the Alvin submersible—renegade deep-sea explorer for the Woods Hole Oceanographic Institute—just got a long-deserved makeover. Alvin is the United States’ only deep-diving manned submersible used for science, so its upgrades will have a serious impact on the discoveries we can pull off in the deep.
Animals took so long to evolve and thrive on Earth because of incredibly low levels of oxygen during a period more than a billion years ago, scientists say.
By combining compounds in just the right mixture, researchers have worked out how to produce the olfactory equivalent of white noise
The pain that scratching causes soothes an itch – but only for a second. As soon as the brain's response to that pain kicks it, it ramps up the itch further
A man's lifelong fear of spiders vanished overnight with the removal of a part of his brain – it gives an insight into where and how our fears are stored
Scientists have been puzzling for years over why some people survive Ebola while many others perish. A new study provides strong evidence that individual genetic differences play a major role in whether people die from the disease.
Zookeepers are keeping an eye on the 120-pound giraffe calf, making sure he's getting all the nutrition he needs. He could make his first appearance in the feeding habitat as soon as next week.
Biologists are reporting signs of a possible zombie apocalypse. Well, at least for the honeybee population. A parasite that has been turning bees on the West Coast into zombie-like creatures has started infecting bees in the East, and biologists are still puzzled as to how it all works.
An innate ability some people have to manipulate their vocal frequency could be the key to sounding charismatic, according to new research.