Researchers have identified a link between higher dietary glycemic load and total carbohydrate intake and increased risk of cancer recurrences or death among stage 3 colon cancer patients, a finding that suggests that diet and lifestyle modification can have a role in improving patient survival, according to a study published November 7 in the Journal of the National Cancer Institute.
The role of one's lifestyle behavior has been shown to play an important role in the development of colorectal cancer. Risk factors, such as obesity and physical activity have been shown to directly influence insulin levels and recent studies have shown a direct link between host factors that lead to hyperinsulinemia and cancer recurrence and mortality in colorectal cancer survivors; however, the influence of glycemic load and other related dietary intakes have on the survival of colon cancer patients is unknown.
In order to determine the effects that glycemic load and total carbohydrate intake have on the survival of stage III colon cancer patients, Jeffrey A. Meyerhardt, M.D., M.P.H., of the Dana-Farber Cancer Institute in Boston and colleagues, performed an observational study on 1,011 stage III colon cancer patients who reported their dietary intake both during and 6 months after participating in an adjuvant chemotherapy trial. The researchers assessed the influence of glycemic load, glycemic index, fructose, and carbohydrate intakes on both mortality and recurrence of the disease.
The researchers found that increasing dietary glycemic load and total carbohydrate intake where both linked with increased cancer recurrence and death and survival of the patients had a distinct correlation with overweight and obese patients. "Given that patients who consume high glycemic loads or carbohydrates after cancer diagnosis may have consumed a similar diet before diagnosis, we cannot exclude the possibility that individuals with these dietary exposures acquire tumors that are biologically more aggressive."
In an accompanying editorial, Neal J. Meropol, M.D. and Nathan A. Berger, M.D. both of the Division of Hematology and Oncology at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine in Cleveland note that these new clinical findings are consistent with an observation more than 50 years ago that cancer cells are "avid sugar consumers." "Although not definitive regarding the impact on colorectal cancer recurrence, the convergence of clinical observations and biology provides a compelling justification to test-hypothesis-driven interventions in prospective randomized clinical trials," the authors write, adding that the study reinforces that, "the epidemiologist is an essential member of the translational science team in oncology."
Journal of the National Cancer Institute: http://jncicancerspectrum.oupjournals.org
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
From Dr Strangelove and water fluoridisation to climate change, scientific method and facts are not always enough to win over the sceptics
On a blog post at PLOS, the tropical disease expert Peter Hotez and postdoctoral fellow Jennifer Herricks take a run through the data on the biggest killers of children around the world in 2013, part of a new dataset from Global Burden of Disease study published in the January Lancet.
Tory MP David Tredinnick seems to believe that astrology could inform and improve UK healthcare. This view is misguided and potentially dangerous
Resistance to vital antimalarial drugs called artemisinins has spread across Burma to the Indian border. If not contained, it could ultimately hit Africa hard
Clostridium difficile sickens nearly half a million Americans annually, killing about 29,000, say federal health officials. They warn hospitals and nursing homes to tighten hygiene protocols.
Study looking at transmission among men who have sex with men recruited 545 participants at high risk of contracting HIV A daily pill can effectively protect gay men against infection with HIV
An experimental therapeutic vaccine from Danish drugmaker Bavarian Nordic helped significantly extend survival in patients with advanced prostate cancer, according to results of a small early-stage trial conducted by the U.S. National Cancer Institute.
Scientists interviewed more than 1,000 men, women and children who were forced into sex work and hard labor. The result is the largest study to detail the health of human trafficking survivors.
Gerbils from Asia rather than black rats were responsible for repeated outbreaks of the bubonic plague in Europe, a study suggests.
The so-called "cuddle-chemical" seems to block the action of alcohol in the brain, preventing the tell-tale signs of drunkenness in rats