Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain.
The study appears online in the October issue of Cancer Research, a publication of the American Association for Cancer Research.
According to the authors, little has been known about the underlying metabolic alterations that may drive the growth of the most aggressive type of glioma, termed glioblastoma.
"For the first time, we have described global metabolomic signatures in glioma," said study corresponding author Prakash Chinnaiyan, M.D., an assistant member in Moffitt's Experimental Therapeutics Program. "This use of metabolomics, which is the global quantitative assessment of metabolites within a biological system, has enabled us to identify some of the central metabolic pathways that allow for these tumors to grow. Our findings provide a unique insight into the underlying biology of glioma and appear to have prognostic significance."
The metabolic studies were carried out at Metabolon Inc. of Durham, N.C., using a nontargeted platform that enabled quantitative analysis of a broad spectrum of molecules.
The established approach for both understanding and treating cancer has largely been genotype based. Unfortunately, clinical gains offered by this level of understanding have been limited, largely based on the complex nature of signaling pathways associated with tumor growth and the inability to delineate the key functional signaling pathways driving growth in an individual tumor.
Chinnaiyan added that although cancers have access to a variety of such pathways, there are a limited number of metabolic strategies they can employ.
"Simply put, with regards to tumor growth, there are several means to the same end. Rather than studying and targeting the means, tumor metabolism represents the end consequence of these aberrant signaling pathways," Chinnaiyan said.
More study will be required to determine the relative importance of these and other metabolic pathways in subtype designation and their overall influence on malignant glioma metabolism. The research team wrote "understanding the glioma metabolome offers the potential for several levels of clinical application, including the possibilities for prognostication and opportunities for personalizing treatment to an individual tumor's metabolic phenotype."
H. Lee Moffitt Cancer Center & Research Institute: http://www.moffitt.usf.edu
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
A woman's biological clock may also tell her cellular time. The number of eggs a woman has shows how fast her cells are ageing and predicts her heart disease risk
Screening people as they cross borders never works well but stopping people leaving affected countries could have devastating consequences
Polish doctors used cells from patient's nose to heal spinal injury
Like any trench war, the fight to protect America's kids against disease is proceeding only inch by inch. A new report shows why there's reason for hope—and reason for worry
Decontaminating biohazard sites can be a tough job, but the hardest microbe to wash away may not be what you think
The discovery of a possible trigger for the onset of Parkinson's disease could lead to new treatments for patients who still depend on a 50-year-old drug
Many people experience severe anxiety in mundane social situations, such as group introductions or paying bills. Why does this happen? And is there any useful purpose to it?
Along with the usual suspects, cigarettes and booze, the European code for avoiding cancer has been updated to include having the HPV vaccine and breastfeeding
Lose the pounds too fast, gain them all back? It seems not. Crash dieters regain the same amount of lost weight as those taking a longer-term approach
A new study suggests a little spending now can buy you a lot of time later