Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain.
The study appears online in the October issue of Cancer Research, a publication of the American Association for Cancer Research.
According to the authors, little has been known about the underlying metabolic alterations that may drive the growth of the most aggressive type of glioma, termed glioblastoma.
"For the first time, we have described global metabolomic signatures in glioma," said study corresponding author Prakash Chinnaiyan, M.D., an assistant member in Moffitt's Experimental Therapeutics Program. "This use of metabolomics, which is the global quantitative assessment of metabolites within a biological system, has enabled us to identify some of the central metabolic pathways that allow for these tumors to grow. Our findings provide a unique insight into the underlying biology of glioma and appear to have prognostic significance."
The metabolic studies were carried out at Metabolon Inc. of Durham, N.C., using a nontargeted platform that enabled quantitative analysis of a broad spectrum of molecules.
The established approach for both understanding and treating cancer has largely been genotype based. Unfortunately, clinical gains offered by this level of understanding have been limited, largely based on the complex nature of signaling pathways associated with tumor growth and the inability to delineate the key functional signaling pathways driving growth in an individual tumor.
Chinnaiyan added that although cancers have access to a variety of such pathways, there are a limited number of metabolic strategies they can employ.
"Simply put, with regards to tumor growth, there are several means to the same end. Rather than studying and targeting the means, tumor metabolism represents the end consequence of these aberrant signaling pathways," Chinnaiyan said.
More study will be required to determine the relative importance of these and other metabolic pathways in subtype designation and their overall influence on malignant glioma metabolism. The research team wrote "understanding the glioma metabolome offers the potential for several levels of clinical application, including the possibilities for prognostication and opportunities for personalizing treatment to an individual tumor's metabolic phenotype."
H. Lee Moffitt Cancer Center & Research Institute: http://www.moffitt.usf.edu
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Avian influenza is ravaging poultry flocks across the Upper Midwest. The virus is "doing things we've never seen it do before," and understanding about transmission is very limited, a scientist says.
Youthful blood has once again shown its promise as an elixir of youth – this time helping to rejuvenate bones. But exactly how it does so is still to be unravelled
LONDON (Reuters) - Victims of childhood bullying are more likely to be overweight or obese as adults and have a higher risk of developing heart disease, diabetes and other illnesses, according to a study by British psychiatrists.
Study finds nixing phones is equivalent to adding an hour of learning to the school week, or five days to the school year
Drug-resistant tuberculosis is a growing problem. It's spread through the air. It can kill you. And it's incredibly difficult to treat. But a program in Peru shows that the disease can be cured.
Scientists have diagnosed strain of leprosy on man from Scandinavia who died in Essex in the fifth or early sixth century
Legalization keeps rolling ahead. But because of years of government roadblocks on research, we don’t know nearly enough about the dangers of marijuana—or the benefits
Landmark genetic study of typhoid has revealed a multidrug-resistant strain sweeping across Asia and Africa, killing 200,000 people a year
Philip Zimbardo is worried that excessive gaming or porn watching is crippling masculinity. But the evidence just doesn’t back up these sorts of claims
Researchers working in the southern African country of Lesotho found that offering lottery tickets to young volunteers, if they can keep themselves HIV negative, is a powerful motivator for safe sex.