After nearly 10 years of follow-up of study participants who experienced migraines and who had brain lesions indentified via magnetic resonance imaging, women with migraines had a higher prevalence and greater increase of deep white matter hyperintensities (brain lesions) than women without migraines, although the number, frequency, and severity of migraines were not associated with lesion progression, according to a study appearing in the November 14 issue of JAMA. Also, increase in deep white matter hyperintensity volume was not significantly associated with poorer cognitive performance at follow-up.
Migraine affects up to 15 percent of the general population. "A previous cross-sectional study showed an association of migraine with a higher prevalence of magnetic resonance imaging (MRI)-measured ischemic lesions in the brain," according to background information in the article. White matter hyperintensities are associated with atherosclerotic disease risk factors, increased risk of ischemic stroke, and cognitive decline.
Inge H. Palm-Meinders, M.D., of the Leiden University Medical Center, the Netherlands, and colleagues conducted a study to determine whether women and men with migraine headaches have a higher incidence of brain lesions 9 years after initial MRI, whether migraine frequency was associated with progression of brain lesions, and whether progression of brain lesions was associated with cognitive decline. In a follow-up of the 2000 Cerebral Abnormalities in Migraine, an Epidemiological Risk Analysis cohort, which is a population-based observational study of Dutch participants with migraine and an age- and sex-matched control group, 203 of the 295 participants at the beginning of the study in the migraine group and 83 of 140 in the control group underwent MRI scan in 2009 to identify progression of MRI-measured brain lesions. Comparisons were adjusted for age, sex, hypertension, diabetes, and educational level. The participants in the migraine group were an average of 57 years of age, and 71 percent were women. Those in the control group had an average age of 55 years, and 69 percent were women.
The researchers found that of the 145 women in the migraine group, 112 (77 percent) vs. 33 of 55 women (60 percent) in the control group had progression of deep white matter hyperintensities. Among men, no association was found between migraine with progression of MRI-measured brain lesions. Although migraine was associated with a higher prevalence of infratentorial (an area of the brain) hyperintensities at follow-up, there were no significant associations of migraine with progression of infratentorial hyperintensities or posterior circulation territory infarctlike lesions among women.
"In addition, the number of migraines, frequency of migraines, migraine severity, type of migraine, and migraine therapy were not associated with lesion progression," the authors write. "Increase in deep white matter hyperintensity volume was not significantly associated with poorer cognitive performance at follow-up."
"In summary, in a community-based cohort followed up for 9 years, migraine was associated only with a higher incidence of deep white matter brain changes among women. There were no significant associations of migraine with progression of other brain lesions among women, and there were no associations of migraine headache with progression of any brain lesions among men. These findings raise questions about the role of migraine headaches with progression of cerebral vascular changes. The functional implications of MRI brain lesions in women with migraine and their possible relation with ischemia and ischemic stroke warrant further research." (JAMA. 2012;308(18):1889-1897)
JAMA and Archives Journals: http://www.jamamedia.org
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
What’s scarier than a tyrannosaur? Three tyrannosaurs.
The timing of when a girl reaches puberty is controlled by hundreds of genes, say scientists.
After the world's most expensive salvage operation, the ill-fated Costa Concordia is being floated back to Genoa, where it will be chopped up for scrap metal
Hijacking how neurons of nematode worms are wired is the first step in an approach that could revolutionise our understanding of brains and consciousness
A Beverly Hills auction house has an unusual fossil for sale. It's not an ancient animal. It's something an ancient animal left behind — and it's very, very long.
Dog owners don't doubt that their pooch has feelings. But scientists aren't so sure. An experiment found that dogs act upset, dare we say jealous, when their owners ignore them for a stuffed animal.
Princeton University’s annual science art contest shines a light on the research world, adding a video element this year
Using mitochondrial replacement therapy to create embryos with DNA from three people could have serious consequences Continue reading...
Chinese and Australian scientists find pandas migrate long distances to maintain a balanced diet which helps them breed
On the morning of March 15, 2000, 17 beaked whales stranded themselves on beaches in the northern Bahamas. It was an terrible and extraordinary event: beaked whales are the world's deepest-diving mammals, and these creatures had spent most of their lives in deep undersea canyons.