Turns out the same glands that make you sweat are responsible for another job vital to your health: they help heal wounds.
Human skin is rich with millions of eccrine sweat glands that help your body cool down after a trip to the gym or on a warm day. These same glands, new University of Michigan Health System research shows, also happen to play a key role in providing cells for recovering skin wounds – such as scrapes, burns and ulcers.
The findings were released online ahead of print in the American Journal of Pathology.
"Skin ulcers – including those caused by diabetes or bed sores – and other non-healing wounds remain a tremendous burden on health services and communities around the world," says lead author Laure Rittié, Ph.D., research assistant professor of dermatology at the University of Michigan Medical School.
"Treating chronic wounds costs tens of billions of dollars annually in the United States alone, and this price tag just keeps rising. Something isn't working."
Now, U-M researchers believe they have discovered one of the body's most powerful secret weapons in healing.
"By identifying a key process of wound closure, we can examine drug therapies with a new target in mind: sweat glands, which are very under-studied," Rittié says. "We're hoping this will stimulate research in a promising, new direction."
Previous understanding of wound closure was that new skin cells originate from hair follicles and from intact skin at the edge of the wound. The U-M findings demonstrate that cells arise from beneath the wound, and suggest that human eccrine sweat glands also store an important reservoir of adult stem cells that can quickly be recruited to aid wound healing.
"It may be surprising that it's taken until now to discover the sweat glands' vital role in wound repair," Rittié says. "But there's a good reason why these specific glands are under-studied – eccrine sweat glands are unique to humans and absent in the body skin of laboratory animals that are commonly used for wound healing research.
"We have discovered that humans heal their skin in a very unique way, different from other mammals," Rittié adds. "The regenerative potential of sweat glands has been one of our body's best-kept secrets. Our findings certainly advance our understanding of the normal healing process and will hopefully pave the way for designing better, targeted therapies."
University of Michigan Health System: http://www.med.umich.edu
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Corals stir up the water, creating vortices that draw in nutrients and drive away waste, research reveals.
The "gold bowl of Hasanlu" and three skeletons were excavated from beneath a burned building in an ancient Iranian citadel – now we know the full story
Study of engravings in Gibraltar cave could be final nail in the coffin of hypothesis that Neanderthals were cognitively inferior to modern humans
Claims that Ai Hin was faking pregnancy to get better treatment have been debunked by leading panda expert
The recent release of Susan Greenfields new book and the film Lucy, both of which are dependent on tired misconceptions or dubious theories about the brain, suggest one worrying conclusion: we are running out of myths about the brain. So here are some new ones, to keep things mysterious
These are the siphonophores, some 180 known species of gelatinous strings that can grow to 100 feet long, making them some of the longest critters on the planet. But instead of growing as a single body like virtually every other animal, siphonophores clone themselves thousands of times over into half a dozen different types of specialized cloned bodies, all strung together to work as a team---a very deadly team at that.
Researchers who study memory have had a thrilling couple of years. Some have erased memories in people with electroshock therapy, for example. Others have figured out, in mice, how to create false memories and even turn bad memories into good ones.
Hunting bats don't just listen out for male frogs' mating calls: they can also use echolocation to detect when the frogs inflate their throat sacs
A crèche of 30 dinosaur infants looked over by an older animal shows that even terrible lizards needed a night away from the kids
Families have identifiable collections of microbes that travel with them. It can take just 24 hours for the microbes to take over a new house