Turns out the same glands that make you sweat are responsible for another job vital to your health: they help heal wounds.
Human skin is rich with millions of eccrine sweat glands that help your body cool down after a trip to the gym or on a warm day. These same glands, new University of Michigan Health System research shows, also happen to play a key role in providing cells for recovering skin wounds – such as scrapes, burns and ulcers.
The findings were released online ahead of print in the American Journal of Pathology.
"Skin ulcers – including those caused by diabetes or bed sores – and other non-healing wounds remain a tremendous burden on health services and communities around the world," says lead author Laure Rittié, Ph.D., research assistant professor of dermatology at the University of Michigan Medical School.
"Treating chronic wounds costs tens of billions of dollars annually in the United States alone, and this price tag just keeps rising. Something isn't working."
Now, U-M researchers believe they have discovered one of the body's most powerful secret weapons in healing.
"By identifying a key process of wound closure, we can examine drug therapies with a new target in mind: sweat glands, which are very under-studied," Rittié says. "We're hoping this will stimulate research in a promising, new direction."
Previous understanding of wound closure was that new skin cells originate from hair follicles and from intact skin at the edge of the wound. The U-M findings demonstrate that cells arise from beneath the wound, and suggest that human eccrine sweat glands also store an important reservoir of adult stem cells that can quickly be recruited to aid wound healing.
"It may be surprising that it's taken until now to discover the sweat glands' vital role in wound repair," Rittié says. "But there's a good reason why these specific glands are under-studied – eccrine sweat glands are unique to humans and absent in the body skin of laboratory animals that are commonly used for wound healing research.
"We have discovered that humans heal their skin in a very unique way, different from other mammals," Rittié adds. "The regenerative potential of sweat glands has been one of our body's best-kept secrets. Our findings certainly advance our understanding of the normal healing process and will hopefully pave the way for designing better, targeted therapies."
University of Michigan Health System: http://www.med.umich.edu
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Though illegal for more than a century, looting Mongolian dinosaur fossils was commonplace – until culture minister Oyungerel Tsedevdamba stepped in (full text available to subscribers)
"This dinosaur has a huge nose"
Is that a giant tooth on your head or are you just happy to see me?
Mother deer rushed towards the infant distress calls of seals, humans and even bats, suggesting that these mammals share similar emotions
In the forests of eastern Australia, a squadron of social spiders faces off against an army of the world's most dangerous ants in a pitched battle for survival
Contrary to some earlier projections, the world's population will soar through the end of the 21st century thanks largely to sub-Saharan Africa's higher-than-expected birth rates, United Nations and other population experts said on Thursday.
Archaeologists got to the root of an ancient hairstyle when they unearthed a 3,300-year-old body with 70 hair extensions
A major international study finds that killings among chimpanzees result from normal competition, not human interference.
Clownfish travel hundreds of kilometres, but it is the larvae rather than the adults that migrate
U.S. government researchers working with divers and sonar equipment have located the wrecks of what they dubbed "forgotten ghost ships" in waters just outside San Francisco's Golden Gate strait.