A well-established family of drugs used to treat parasitic diseases is showing surprising potential as a therapy for tuberculosis (TB), according to new research from University of British Columbia microbiologists.
The findings, published online this week in the journal Antimicrobial Agents and Chemotherapy, are based on in vitro tests of the avermectin family of drugs. Discovered nearly 40 years ago, the drugs are commonly used in the developing world to eliminate the parasitic worms that cause river blindness and elephantiasis but have been thought to be ineffective against bacterial diseases. The UBC study shows that in the lab, the drugs actually killed the bacteria that cause TB, including drug resistant forms.
"These drugs are cheap, routinely produced by pharmaceutical companies, and, in many cases, approved for humans use," says UBC researcher Santiago Ramón-García, a co-author on the paper. "So the jump from lab bench to clinic could be much quicker."
"In addition, the drug concentrations effective in vitro indicate members of this family might be very valuable additions to the small repertoire of drugs we have to fight multi-drug resistant TB, which have very low probabilities of being cured."
The international collaboration was lead by scientists in UBC's Department of Microbiology and Immunology associated with UBC's Centre for Tuberculosis Research and the Neglected Global Diseases Initiative.
"This underscores the great potential for investments in research to find new uses for approved drugs or synergistic drug combinations," says co-author and UBC microbiologist Charles Thompson.
Further studies are needed to assess the drugs' clinical application for treating TB. UBC researchers are now working with animal models to determine effective dosage levels and regimens. They will also study whether avermectins could be combined with other drugs to create effective therapies.
University of British Columbia: http://www.ubc.ca
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Scientists never understood what became of the Paleo-Eskimos who once peopled the north. Now they know—and there's new reason to miss them
NOAA whittles down initial list of 66 species to be covered by Endangered Species Act
Unusual fish with lungs have developed walking techniques and bodies like those of the ancestors of four-legged animals after being raised on land
A new atlas draws on thousands of records reaching back to the 18th century and describes more than 9000 species, ranging from microbes to whales
The frailty of remembrance might have an upside: When a memory is recalled, two research teams reported on Wednesday, it can be erased or rewired so that a painful recollection is physically linked in the brain to joy and a once-happy memory to pain.
There were some fine vintages 3,000 years ago, and a new study reveals how ancient mixologists made them finer still
Growing nerve tissue and organs is a sci-fi dream. I met the pioneering researcher who grew eyes and brain cells
Australian researchers want tourists to send in photos of flukes so they can track eastern humpback whale movements
Scientists produce a simple mathematical model that explains how a single sheepdog can herd a large number of sheep.
A North Texas family, who discovered the skeleton of a 20,000- to 40,000-year-old mammoth while mining through sediment on their farm, is preparing to turn over the remains to a local museum.