Herbs widely used throughout history in Asian and early European cultures have received renewed attention by Western medicine in recent years. Scientists are now isolating the active compounds in many medicinal herbs and documenting their antioxidant and anti-inflammatory activities. In a study published in the journal Investigative Ophthalmology & Visual Science, Stuart A. Lipton, M.D., Ph.D. and colleagues at Sanford-Burnham Medical Research Institute (Sanford-Burnham) report that carnosic acid, a component of the herb rosemary, promotes eye health.
Lipton's team found that carnosic acid protects retinas from degeneration and toxicity in cell culture and in rodent models of light-induced retinal damage. Their findings suggest that carnosic acid may have clinical applications for diseases affecting the outer retina, including age-related macular degeneration, the most common eye disease in the U.S.
Age-related macular degeneration
Age-related macular degeneration likely has many underlying causes. Yet previous studies suggest that the disease might be slowed or improved by chemicals that fight free radicals—reactive compounds related to oxygen and nitrogen that damage membranes and other cell processes.
Lipton's team first discovered a few years ago that carnosic acid fights off free radical damage in the brain. In their latest study, Lipton and colleagues, including Tayebeh Rezaie, Ph.D. and Takumi Satoh, Ph.D., initially investigated carnosic acid's protective mechanism in laboratory cultures of retinal cells.
The researchers exposed the cells growing in the dish to hydrogen peroxide in order to induce oxidative stress, a factor thought to contribute to disease progression in eye conditions such as macular degeneration and retinitis pigmentosa. They found that cells treated with carnosic acid triggered antioxidant enzyme production in the cells, which in turn lowered levels of reactive oxygen and nitrogen species (cell-damaging free radicals and peroxides).
Rosemary's therapeutic potential
Lipton, Rezaie, Satoh and colleagues next tested carnosic acid in an animal model of light-induced damage to photoreceptors—the part of the eye that converts light to electrical signals, enabling visual perception. As compared to the untreated group, rodents pre-treated with carnosic acid retained a thicker outer nuclear layer in the eye, indicating that their photoreceptors were protected. The carnosic acid-treated rodents also exhibited better electroretinogram activity, a measure of healthy photoreceptor function.
What's next for carnosic acid? "We're now developing improved derivatives of carnosic acid and related compounds to protect the retina and other brain areas from a number of degenerative conditions, including age-related macular degeneration and various forms of dementia," said Lipton, director of Sanford-Burnham's Del E. Webb Neuroscience, Aging, and Stem Cell Research Center and an active clinical neurologist.
Sanford-Burnham Medical Research Institute: http://www.burnham-inst.org
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Scientists circumnavigating the globe on a spartan racing catamaran will spend the coming year deploying drones to collect better data on plastic pollution
A patch of gold electrodes you can wear behind your ear for up to two weeks will track your brainwaves 24/7 and let you control devices with your mind
Scientists have peeked inside the brain of a man with tinnitus to identify the brainwaves that underlie the debilitating sensation of ringing in the ear
For extinct creatures like dinosaurs known only from fossils, it is notoriously difficult to differentiate the males from the females of a species because sex distinctions are rarely obvious from the skeletons.
The most complete genetic information assembled on woolly mammoths is providing insight into their demise, revealing they suffered two population crashes before a final, severely inbred group succumbed on an Arctic Ocean island.
More than 30 million crows fly around the country, but among all creatures, the birds may be among the least understood. Ben Tracy reports on new research into crows' brains.
Mouse study demonstrates method to target mutations in DNA inherited from mother
After consulting a "stud book," the Zoo brought a male panda's sperm back to D.C., setting an exciting precedent
Stegosaurs may have sported quite different shaped bony plates on their backs, depending on whether they were male or female, new research claims.
Targeting a protein that causes rampant growth of cells in retinal blood vessels could lead to new treatments for vision loss in older people