As insects evolve to become resistant to insecticides, the need to develop new ways to control pests grows. A team of scientists from Leuven, Belgium have discovered that the sea anemone's venom harbors several toxins that promise to become a new generation of insecticides that are environmentally friendly and avoid resistance by the insects. Since these toxins disable ion channels that mediate pain and inflammation, they could also spur drug development aimed at pain, cardiac disorders, epilepsy and seizure disorders, and immunological diseases such as multiple sclerosis. This finding is described in the December 2012 issue of The FASEB Journal.
"Are toxins friend or foe? The more we understand these toxins, they are more friend, and less foe," said Jan Tytgat, Ph.D., co-author of this study from the Laboratory of Toxicology at the University of Leuven in Leuven, Belgium. "Toxicology shows us how to exploit Mother Nature's biodiversity for better and healthier living."
To make this discovery, Tytgat and colleagues extracted venom from the sea anemone, Anthopleura elegantissima, and purified three main toxins present in the venom. The toxins were characterized in depth, using biochemical and electrophysiological techniques. This provided insight into their structure, functional role and mechanisms of action. The discovery of these toxins may be considered similar to the discovery of a new drug, as they are compounds which could lead to new insecticides and possibly new treatments for human diseases.
"Because these toxins are aimed at important ion channels present not only in insect cells, they form the leading edge of our new biotechnology. Discovery of this useful marine toxin should provide additional incentive to preserve the fragile coral reefs where anemones thrive," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "But, given current attitudes, I suspect there's a better chance of a sea anemone killing a stink bug than for us to reverse our inroads on ocean life."
Federation of American Societies for Experimental Biology: http://www.faseb.org
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Dinosaurs, those bygone masters of the planet, were warm-blooded just like today's mammals, according to a scientist who judged their metabolism using body mass and growth rates deduced from fossils of species including Tyrannosaurus rex.
Previously unknown prehistoric beaver bears an uncanny likeness to the modern state symbol
The latest research shows memories “lost” to amnesia aren’t gone forever; they’re just not accessible
The chief disease agency in the U.S. is looking into why the spores shipped to laboratories in nine states and a military base in South Korea hadn't been properly neutralized. So far no one is sick.
When players can change tactics, the game loops endlessly between the three weapons
When you spend five years watching kangaroos, you start to see some strange things.
Nearly three-quarters of fresh shop-bought chickens test positive for food poisoning bug campylobacter in year-long study.
Designed to give paralysed people more independence, the implant also lets us see if brain activity can show a person's decisions – before they realise they've made any
Australopithecus deyiremeda, which lived about 3.4 million yeas ago, suggests our ancestors were more diverse than we thought
Scientists say it's not just a murder from another era, but also part of one of the earliest mass graves.