A scientist at the University of British Columbia and Vancouver Coastal Health has identified the molecule that controls a scissor-like protein responsible for the production of plaques – the telltale sign of Alzheimer's disease (AD).
The molecule, known as GSK3-beta, activates a gene that creates a protein, called BACE1. When BACE1 cuts another protein, called APP, the resulting fragment – known as amyloid beta – forms tiny fibers that clump together into plaques in the brain, eventually killing neural cells.
Using an animal model, Dr. Weihong Song, Canada Research Chair in Alzheimer's Disease and professor of psychiatry, found that disabling GSK3-beta's effect in mice resulted in less BACE1 and far fewer deposits of amyloid in their brains. Song's research, published online today in the Journal of Clinical Investigation, also found that such mice performed better than untreated mice on memory tests.
Previous research had shown that GSK3-beta spurred the growth of twisted fibers inside neurons, known as tangles – another hallmark of AD. Song says his discovery of the protein's dual destructiveness makes it a promising target for drug research.
GSK3-beta, however, is a versatile enzyme that controls many vital physiological functions. The drug used to inhibit GSK3-beta in the mice is too indiscriminate, and could cause several serious side effects, including cancer.
"If we can find a way to stop GSK3-beta's specific reaction with BACE1, and still leave it intact to perform other crucial tasks, we have a much better chance of treating AD and preventing its progression," says Song, a member of the Brain Research Centre at UBC and the Vancouver Coastal Health Research Institute (VCHRI), and Director of the Townsend Family Laboratories at UBC.
University of British Columbia: http://www.ubc.ca
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
New study reveals participants unconsciously sniff their right hand after shaking it with others as part of process to pick up chemical signals about others
If you have ever struggled through a math class, you may not think of numbers as natural.
DNA analysis has revealed evidence for a massive migration into the heartland of Europe 4,500 years ago.
In the days before Amazon and TripAdvisor, how could you express your consumer outrage? For ancient Mesopotamians, it was seethe, stamp and bake
Alzheimer's researchers at Harvard for the first time are scanning the brains of healthy patients for the presence of a hallmark protein called tau, which forms toxic tangles of nerve fibers associated with the fatal disease.
Evidence of an ancient settlement was found in the most inaccessible forest in Central America
Strong drugs are rarely warranted to control the behavior of dementia patients, specialists say. But antipsychotic medicine is being overprescribed, and not just among residents of nursing homes.
Scientists are refining what constitutes "normal"
Bumblebees can recall which flowers yield nectar, but like people they can get mixed up – leading them to home in on flowers they have no experience of