It's common knowledge that excessive UV exposure from sunlight raises your chances for skin cancer, but predicting whether someone will actually develop skin cancer remains difficult. In a new research report, scientists from the University of Alabama at Birmingham (UAB) and the University of Wisconsin–Madison show that the risk for skin cancer involves numerous genetic factors including family history, ethnicity, and genetic variations specific to each individual. Using these factors, the researchers developed a more precise model for assessing risk, which is published in the December 2012 issue of the journal Genetics.
"We hope this study will ultimately contribute toward a better understanding of the genetics of complex traits and diseases," said Ana Inés Vázquez, PhD, lead author of the study from UAB's Department of Biostatistics. "Such an understanding is essential for the development of methods that can be used for early and improved prediction of genetic predisposition to diseases."
To make this discovery, the scientists used phenotypic and genetic information from more than 5,000 familial participants in the Framingham Heart Study to develop various models for assessing skin cancer risk. The researchers' most basic risk evaluation model included standard risk factors such as sex. Additional predictive models were developed by adding information on family history, ethnicity, and data from 41,000 genetic markers across the human genome. The predictive power of each model was evaluated, with the best prediction accuracy obtained from models that include all predictive risk factors -- those standard risk factors plus family history, ethnicity and genetic markers.
"Although there is no doubt that sun exposure increases your risk for skin cancer," said Mark Johnston, Editor-in-Chief of the journal Genetics, "it isn't clear how much of a risk it poses to each individual. This new model for assessing risk should prove useful to health care providers and public health officials, who play a crucial role in educating people about preventing skin cancer."
Genetics Society of America: http://www.genetics-gsa.org/
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
South Africa has begun testing a humane way to make its beaches safer
There used to be rhinos in North America. In fact, they originated on the continent. The earliest ones …
James Watson is to sell the Nobel Prize medal he won for the discovery of the structure of DNA.
An international team of more than 100 researchers has mapped the genome of the centipede and found that, while it easily outpaces humans on number of legs, it falls short when it comes to genes.
The tech giant has created a utensil to make mealtime easier for people with Parkinson's disease and essential tremors
The brain has a weak spot for Alzheimer's disease and schizophrenia, according to experts who have pinpointed the region using scans.
Scientists in California have captured the elusive anglerfish on film in its natural habitat, 1,900 feet below sea level
Researchers were shocked to discover multiple instances of seal-on-penguin rape
The tiny shrimp survive without sunlight and crawl within an inch of boiling hot waters
Birds are one of the most widely studied forms of life on the planet. And, there are still new species out there to discover — as one young researcher found recently in a forest in Indonesia.