Fertility tests frequently reveal that males have problems with the quality of their sperm. The problems often relate to sperm senescence, which is a reduction in quality with age. Sperm senescence can arise either before or after the DNA in the sperm cells is produced by a process known as meiosis. So-called "pre-meiotic" senescence results from accumulated damage in the germline cells with increasing age and results in older males having sperm of lower quality. Post-meiotic senescence occurs after the sperm cells have been produced, either during storage of sperm by the male or after ejaculation and before they fertilize the eggs.
There is previous evidence that various kinds of sperm senescence occur in insects, in some domestic animals (birds and mammals) and even in humans but the studies have generally been carried out under fairly artificial conditions and so it is not clear how they relate to wild animals – or to the general human population. These objections have been overcome in the latest work of Attila Hettyey and colleagues at the Konrad Lorenz Institute of Ethology, University of Veterinary Medicine, Vienna (Vetmeduni), together with Balázs Vági in Budapest, Hungary, where Hettyey himself is now working.
The researchers investigated the common toad, an interesting model system as it is known to produce all its sperm before the start of the breeding season. They found that male toads that re-entered hibernation at the start of the breeding season, i.e. that lowered their metabolic rates after producing sperm, stored sperm of significantly higher motility than males kept under pseudo-natural conditions without females throughout the entire breeding season. The result means that slowing the normal rate of general physiological processes reduced the normal rate of sperm ageing within the toad's testicles. This constitutes the first evidence for post-meiotic intra-testicular sperm senescence in a wild vertebrate. A further surprising result was that in males kept under pseudo-natural conditions, sperm motility was related to the number of matings a male achieved, with the presence of females or the occurrence of matings having a positive effect on the quality of stored sperm. This suggests that post-meiotic intra-testicular sperm senescence does not occur at a fixed rate but may be modulated by external factors, such as temperature and number of matings.
In summary, the scientists at the Vetmeduni have shown that sperm senescence occurs while sperm are stored in the testicles of animals living under essentially "natural" conditions. They also suggest that the rate of sperm senescence can be slowed if males mate more frequently. For animals that produce sperm continuously, such as man, the implications seem to be that more frequent ejaculations serve both to remove older and thus less viable sperm as well as to reduce the damage to sperm cells during storage. The senior author on the PlosONE paper, Richard Wagner, is keen to speculate on the importance of the results. "We do not yet know how general post-meiotic sperm senescence is in wild animals, or man. But if it turns out to be widespread, it will be fascinating to see how it affects reproductive behaviour." As Hettyey says, "Females may try to avoid males with damaged sperm while males may choose particular environments that slow sperm senescence and may attempt to shorten periods of sexual rest by also accepting matings with low-quality females or by discharging aged sperm."
The paper "Post-meiotic intra-testicular sperm senescence in a wild vertebrate" by Attila Hettyey, Balázs Vági, Dustin J Penn, Herbert Hoi and Richard H. Wagner has just been published in the online journal "PlosONE" (doi:10.1371/journal.pone.0050820).
The scientific article in full text online (Open Access): http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050820
University of Veterinary Medicine -- Vienna: http://www.vetmeduni.ac.at
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
With funding from the Defense Department, scientists have begun work on devices that would use electric pulses to realign a memory process gone awry
On Friday, the Food and Drug Administration released a vital set of numbers about the routine use of antibiotics …
Side order of veg with that mammoth leg? The Neanderthal diet was probably more varied than we think – using vegetables, herbs and different cooking techniques
An exoskeleton that enables movement and provides tactile feedback has helped eight paralysed people regain sensation and move previously paralysed muscles
A female western gray whale set a new record swimming from Russia to Mexico and back, a total of 13,988 miles, in 172 days
Scientists operating a remote-controlled vehicle about 2,000 feet below water get a rare glimpse of a sperm whale. CBSN's Vladimir Duthiers and Elaine Quijano report on the video.
According to the experts, "blinking is like a kitty kiss"
Genetic profiling of cancer cells can help guide treatment, but such profiles can be ambiguous. Results would be more accurate if all labs tested normal cells from each patient, too.
Researchers in Kenya uncover tools dated to 3.3 million years ago, long before the first humans, as we know them, walked the Earth.
Researchers are facing up to methodological flaws that plague functional magnetic resonance imaging, but the interpretative problems might be harder to solve