New research from Western University could lead to better treatments for Post-Traumatic Stress Disorder (PTSD) and drug addiction by effectively blocking memories. The research performed by Nicole Lauzon, a PhD candidate in the laboratory of Steven Laviolette at Western's Schulich School of Medicine & Dentistry has revealed a common mechanism in a region of the brain called the pre-limbic cortex, can control the recall of memories linked to both aversive, traumatic experiences associated with PTSD and rewarding memories linked to drug addiction. More importantly, the researchers have discovered a way to actively suppress the spontaneous recall of both types of memories, without permanently altering memories. The findings are published online in the journal Neuropharmacology.
"These findings are very important in disorders like PTSD or drug addiction. One of the common problems associated with these disorders is the obtrusive recall of memories that are associated with the fearful, emotional experiences in PTSD patients. And people suffering with addiction are often exposed to environmental cues that remind them of the rewarding effects of the drug. This can lead to drug relapse, one of the major problems with persistent addictions to drugs such as opiates," explains Laviolette, an associate professor in the Departments of Anatomy and Cell Biology, and Psychiatry. "So what we've found is a common mechanism in the brain that can control recall of both aversive memories and memories associated with rewarding experience in the case of drug addiction."
"In the movie, 'Eternal Sunshine of a Spotless Mind,' they attempted to permanently erase memories associated with emotional experiences," adds Laviolette. "The interesting thing about our findings is that we were able to prevent the spontaneous recall of these memories, but the memories were still intact. We weren't inducing any form of brain damage or actually affecting the integrity of the original memories."
University of Western Ontario: http://www.uwo.ca
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Ah, motherhood. I don’t know anything about it, but I heard there’s a lot of, like, sacrifice and stuff. Not only do you have to bring the brat into the world, but then you have to feed it for at least 18 years or you get in big trouble. That’s a lot of pressure.
It’s three in the morning in South Africa, in the middle of winter. Temperatures have dropped to just …
A jellyfish tagging study reveals the creatures' ability to swim against the current when forming their submarine swarms, say researchers.
Size isn't everything. When many male mice mate with the same females, their descendants evolve testes that can produce more sperm
Along the seashore, harmful blooms caused by an organism called Sea Sparkle choke ecosystems but look positively enchanting
The opposable thumb you use to hold a pencil was long thought to be a defining aspect of humans. But an analysis of finger bones suggests stone tool use by pre-humans — perhaps 3 million years ago.
Blind since birth, Julee-anne Bell wasn't comfortable heading out on her own. And when she learned an echolocation technique that gave her more independence, she discovered that it came with costs.
In tight times, cuts urged for ocean observing network and ships
By making E. coli dependent on an artificial amino acid, scientists hope to show that engineered organisms can be safer and more useful for industrial processes like drug production.
The frilled shark's roots are traced to 80 million years ago. Its prehistoric origins are obvious in its primitive body; nearly all of the rare animal's closest relatives are long extinct.