Researchers at Oregon Health & Science University's School of Dentistry have made an important connection between a molecule critical to nerve cells and high blood pressure. Production of the molecule Brain-Derived Neurotrophic Factor (BDNF) appears to increase dramatically in blood pressure-sensing nerve cells during hypertension. The study, published online in the Journal of Neuroscience Research, may someday have implications for the prevention and treatment of high blood pressure, which affects about one in three adults in the United States.
BDNF is essential to the normal development and plasticity of nerve cells. Using two distinct hypertensive animal models, OHSU team data suggest a direct role of BDNF in regulation of blood pressure.
"We are now able to knock down BDNF in the blood pressure control system and can move toward answering the next critical question, which is whether BDNF contributes to the development of hypertension, or whether it provides a compensatory mechanism counteracting those that lead to hypertension" said Agnieszka Balkowiec, M.D., Ph.D., associate professor of integrative biosciences, OHSU School of Dentistry, and adjunct assistant professor of physiology and pharmacology, OHSU School of Medicine, whose lab teamed with Virginia Brooks, Ph.D., professor of physiology and pharmacology in the OHSU School of Medicine.
Previous studies from Balkowiec's lab showed that BDNF is made by blood pressure-sensing nerve cells called 'baroreceptors'. BDNF is released from the baroreceptors onto relay cells in the brainstem when nerve activity rises, as in hypertension
Oregon Health & Science University: http://www.ohsu.edu
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
The Nikon Small World photomicrography competition was expanded to include video three years ago, and the result has been an incredible look into living things on the microscopic scale. This year's winning video is a three-dimensional look through a 10-day-old quail embryo growing inside its egg.
On a foggy night in 1888, the passenger steamer City of Chester was headed out of San Francisco Bay when disaster struck. The 202-foot boat was rammed by a much larger steamer, the Oceanic, coming into the bay from Asia. Sixteen people died in the accident, and the City of Chester quickly sank to the bottom. This multibeam sonar image from NOAA is the first look at the steamer in well over a century.
People who have lost their hearing will be injected with a harmless virus carrying a gene that should trigger the regrowth of their ears' sensory receptors
She lived to 115, but a study of Hendrikje van Andel-Schipper's blood hints at factors limiting lifespan
Most of us aren't as maleficent as the fairy in "Sleeping Beauty," but we're still apt to spite others, even at risk of harming ourselves. Psychologists are trying to figure out why.
PTSD treatments could soon extend beyond therapy
Areas where Czechoslovakia had three electrified fences now avoided by generation of deer who never encountered them
The mystery of a bizarre quacking sound often heard in the Southern Ocean has finally been solved, scientists report.
Why the connections between brain cells in depressed people are often shrivelled was a mystery – but a single protein could be to blame
The threat of mutually assured destruction, military or economic, promotes peace in many places. If war has ultimately forged a safer world, what's next?