Low prediagnostic levels of circulating adiponectin were associated with an increased risk of pancreatic cancer, according to a study published December 14 in the Journal of the National Cancer Institute.
Pancreatic cancer is the fourth leading cause of cancer death in the U.S., but its etiology remains unclear. Adiponectin, a hormone secreted from fat cells, has insulin-sensitizing and anti-inflammatory properties. Low adiponectin plasma levels are associated with the insulin resistance that manifests in obesity and diabetes mellitus, both of which are risk factors for pancreatic cancer.
In order to determine if prediagnostic plasma levels of adiponectin were linked to an increased risk of pancreatic cancer, Ying Bao, M.D., Sc.D., Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and colleagues, pooled the data from five prospective U.S. cohort studies, and matched 468 pancreatic cancer case subjects with 1,080 healthy control subjects by cohort, year of birth, smoking status, fasting status, and month of blood draw. They assessed the association between adiponectin and pancreatic cancer risk with conditional logistic regression.
The researchers found a statistically significant inverse association between prediagnostic plasma adiponectin levels and the risk of pancreatic cancer in the five prospective cohorts. "Our data provide additional evidence for a biological link between obesity, insulin resistance, and pancreatic cancer risk and also suggest an independent role of adiponectin in the development of pancreatic cancer," the authors write.
In an accompanying editorial, Jianliang Zhang, Ph.D., Associate Professor of Oncology and Steven N. Hochwald, M.D., Department of Surgical Oncology, both of the Roswell Park Cancer Institute, write that the study establishes a link between adiponectin levels and pancreatic cancer risk that suggests that metabolism contributes to the pathophysiology of pancreatic cancer. "Early detection by the assessment of adiponectin has the potential to improve the survival rates of pancreatic tumor patients," the authors write. "It is also inviting to speculate that therapeutic interventions to increase the levels of circulating adiponectin may prevent the development of pancreatic cancer and/or improve the survival of patients with malignancy."
Journal of the National Cancer Institute: http://jncicancerspectrum.oupjournals.org
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
From Dr Strangelove and water fluoridisation to climate change, scientific method and facts are not always enough to win over the sceptics
On a blog post at PLOS, the tropical disease expert Peter Hotez and postdoctoral fellow Jennifer Herricks take a run through the data on the biggest killers of children around the world in 2013, part of a new dataset from Global Burden of Disease study published in the January Lancet.
Tory MP David Tredinnick seems to believe that astrology could inform and improve UK healthcare. This view is misguided and potentially dangerous
Resistance to vital antimalarial drugs called artemisinins has spread across Burma to the Indian border. If not contained, it could ultimately hit Africa hard
Clostridium difficile sickens nearly half a million Americans annually, killing about 29,000, say federal health officials. They warn hospitals and nursing homes to tighten hygiene protocols.
Study looking at transmission among men who have sex with men recruited 545 participants at high risk of contracting HIV A daily pill can effectively protect gay men against infection with HIV
An experimental therapeutic vaccine from Danish drugmaker Bavarian Nordic helped significantly extend survival in patients with advanced prostate cancer, according to results of a small early-stage trial conducted by the U.S. National Cancer Institute.
Scientists interviewed more than 1,000 men, women and children who were forced into sex work and hard labor. The result is the largest study to detail the health of human trafficking survivors.
Gerbils from Asia rather than black rats were responsible for repeated outbreaks of the bubonic plague in Europe, a study suggests.
The so-called "cuddle-chemical" seems to block the action of alcohol in the brain, preventing the tell-tale signs of drunkenness in rats