Scientists from the RIKEN Advanced Science Institute in Japan and University of California Los Angeles report a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream.This new nanotechnology could be used for cancer diagnosis and give insight into the mechanisms of how cancer spreads throughout the body. The device provides a convenient and non-invasive alternative to biopsy, the current method for diagnosis of metastatic cancer. It could enable doctors to detect tumor cells that circulate in cancer patients' blood well before they subsequently colonize as tumors in other organs. The device also enables researchers to keep the tumor cells alive and subsequently study them.
The device was developed by a team led by Hsiao-hua Yu from the RIKEN Advanced Science Institute in Japan and Hsian-Rong Tseng from the Department of Molecular and Medical Pharmacology at the University of California Los Angeles, in research published online today in the journal Advanced Materials.
Similar cell-capture devices have been reported but this technology is unique in that it is capable of catching the tumor cells with great efficiency and releasing them with great cell viability. Blood is passed through the device like a filter that contains a molecule capable of adhering to tumor cells like Velcro and separating them with efficiency ranging from 40% to 70%. The cancer cells are retained by tiny temperature-responsive polymer brushes inside the device. At 37 degrees Celsius, these polymer brushes stick to the tumor cells, but when cooled to 4 degrees Celsius, they release them, allowing scientists to examine the cells.
"Until now, most devices have demonstrated the ability to capture circulating tumor cells with high efficiency. However, it is equally important to release these captured cells, to preserve and study them in order to obtain insightful information about them. This is the big difference with our device." Explains Hsiao-hua Yu, who led the team that developed the technique to coat the device with polymer brushes.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Swallowing a sulfur-rich protoplanet could help explain two lingering mysteries in the story of Earth's formation
In a first-of-its-kind endeavor, electricity-starved Rwanda and the Democratic Republic of Congo are trying to get power from a lake—and avert catastrophe.It’s a Friday afternoon on the Rwandan side of Lake Kivu, and in what was once a quiet cove, a daring venture is taking shape.
The good news is that an eruption there is highly unlikely, but the bad news is that it would be huge
Flame-retardant fabrics normally degrade when washed, but a water-repelling coating could make your flame-proof suit or sofa self-cleaning
It may look like nothing more than a small ball of metal, but the shape-shifting and self-propulsion abilities of a liquid metal alloy discovered by scientists at China's Tsinghua University has captured the imaginations of scientists and science-fiction fans across the world.
The same receptor on nerve endings that makes sinuses tingle when we eat wasabi plays an important role in the pain of inflammation. The first 3-D view of the receptor could lead to better pain drugs.
As the craft beer industry grows, so are options for learning to brew. More colleges are now introducing degree programs to teach the art and science of beer-making.
Researchers were surprised by what they found when they sandwiched a drop of water between two layers of an unusual two-dimensional material called graphene.
Scientists at Cern are suggesting they could soon detect miniature black holes, proving the existence of parallel universes and disproving the big bang theory of the creation of the universe.
The Curiosity rover makes a detection of nitrogen compounds which provide further evidence that ancient Mars would have been a habitable world.