Scientists from the RIKEN Advanced Science Institute in Japan and University of California Los Angeles report a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream.This new nanotechnology could be used for cancer diagnosis and give insight into the mechanisms of how cancer spreads throughout the body. The device provides a convenient and non-invasive alternative to biopsy, the current method for diagnosis of metastatic cancer. It could enable doctors to detect tumor cells that circulate in cancer patients' blood well before they subsequently colonize as tumors in other organs. The device also enables researchers to keep the tumor cells alive and subsequently study them.
The device was developed by a team led by Hsiao-hua Yu from the RIKEN Advanced Science Institute in Japan and Hsian-Rong Tseng from the Department of Molecular and Medical Pharmacology at the University of California Los Angeles, in research published online today in the journal Advanced Materials.
Similar cell-capture devices have been reported but this technology is unique in that it is capable of catching the tumor cells with great efficiency and releasing them with great cell viability. Blood is passed through the device like a filter that contains a molecule capable of adhering to tumor cells like Velcro and separating them with efficiency ranging from 40% to 70%. The cancer cells are retained by tiny temperature-responsive polymer brushes inside the device. At 37 degrees Celsius, these polymer brushes stick to the tumor cells, but when cooled to 4 degrees Celsius, they release them, allowing scientists to examine the cells.
"Until now, most devices have demonstrated the ability to capture circulating tumor cells with high efficiency. However, it is equally important to release these captured cells, to preserve and study them in order to obtain insightful information about them. This is the big difference with our device." Explains Hsiao-hua Yu, who led the team that developed the technique to coat the device with polymer brushes.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Institute for Highway Safety is known for crash-test safety ratings, but as cars get smarter there's a need to look beyond crashworthiness
Researchers have long struggled to resolve what happens to information when it falls inside a black hole, but the famous physicist says he has a solution
Researchers have been using muons to take a peek inside the nuclear reactors in Japan that melted down in 2011. The results could aid the continuing cleanup operations.
Neutrinos, created by violent phenomena such as black holes and exploding stars, could hold the key to the universe’s most distant and mysterious events
Better MRI scanners could result from a trick in which a magnetic field springs up from nowhere, using materials famous for their link to invisibility cloaks
Water locked away in rocks for 1.5 billion years reveals conditions were right for complex organic molecules to form in deep sea hydrothermal vents
Helium, used in nuclear, medical and, yes, party industries, has become scarce, but new research has revealed a possible way to pinpoint fresh sources
New lab results show how collisions between comets and planets can make the molecules that are the essential building blocks of life.
A startup company says it is expanding the language of DNA to create new tools for drug discovery.
If scientists can convince people to use the app, they hope it will help them solve a cosmic mystery. This story originally aired on March 27, 2015 on All Things Considered.