Scientists at the Keck School of Medicine of the University of Southern California (USC) have found evidence that liver mitochondria in mice adapt to become better metabolizers of alcohol and increase in number after chronic exposure, which may raise the potential for free radical damage associated with aging and cancer over time.
The liver is a vital organ, playing a major role in metabolism and detoxification in the body. Overconsumption of alcohol has long been tied to liver diseases such as fatty liver, alcoholic hepatitis and cirrhosis, but how the substance damages the organ is not fully understood. USC research published in the Dec. 7, 2012, issue of the Journal of Biological Chemistry, a peer-reviewed scientific journal, suggests that mitochondria play an important role in the liver's response to the metabolic stress caused by alcohol intake. If scientists observe the same results in human mitochondria, it could help pinpoint targets for therapy.
"The liver has to adapt quickly to various toxins and drugs to meet the demands we place on the body," said Derick Han, Ph.D., assistant professor of research medicine at the Keck School of Medicine of USC and first author of the study. "We've found that mitochondrial plasticity — the mitochondria's ability to change — is probably central to the liver's response to alcohol intake. This gives us a better understanding of how the liver works and how it adapts to stress."
Mitochondria are cellular organelles that generate most of the cell's energy; they have been implicated in certain neurological disorders and have been tied to aging. The metabolism of oxygen by the mitochondria normally generates reactive oxygen species, or free radicals, which in excess can be highly damaging to cells.
"In the short term, it looks like mitochondria adapt to metabolize alcohol better, but as they increase in number and use more oxygen to help metabolize that alcohol, it could be harmful to the body," Han said.
Han and his team of scientists fed alcohol to mice over four weeks, isolated the liver mitochondria and measured levels of respiration and changes in the mitochondrial structure. They found significant increases in oxygen consumption by mice fed the alcohol in comparison to control mitochondria as early as one week after feeding. Changes were greater and more extensive with higher alcohol intake.
University of Southern California - Health Sciences: http://uscnews.usc.edu/archives/health/
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Scientists find that antiretroviral treatment should be administered before HIV virus has weakened the immune system
Discovery of method for blocking enzyme that spreads cancer cells to bones is described as ‘important progress’ in prevention of secondary stage of disease
It seemed to make sense that the childhood Hib vaccine could cut leukemia risk by keeping the immune system in check. But proving there's cause and effect at work turns out to be a challenge.
A U.K. researcher says the environmental argument for eating bugs isn't working on its own. She says chefs and policymakers must "make insect dishes appeal as food, not just a way to save the planet."
Eating healthy is easier said than done. Same with buying healthy food. Research finds that putting in partitions in grocery carts can increase the likelihood shoppers buy healthy fruits and veggies.
Genetic study could provide hope for men with advanced forms of the disease with findings that could lead to personalised treatments
The agency that administers Obamacare in California moved to make expensive medicines more affordable in 2016. In most plans, patients will pay no more than $150 or $250 a month.
When former prisoners flock together, more land back in jail
Avian influenza is ravaging poultry flocks across the Upper Midwest. The virus is "doing things we've never seen it do before," and understanding about transmission is very limited, a scientist says.
Youthful blood has once again shown its promise as an elixir of youth – this time helping to rejuvenate bones. But exactly how it does so is still to be unravelled