Despite more than 25 years of research on antiobesity drugs, few medications have shown long-term success. Now researchers reporting online on December 21 in the Cell Press journal Trends in Endocrinology & Metabolism say that targeting taste sensors in the gut may be a promising new strategy.
The gut "tastes" what we eat—bitter, sweet, fat, and savory—in much the same way as the tongue and through the use of similar signaling mechanisms. The result is the release of hormones to control satiety and blood sugar levels when food reaches the gut. The sensors, or receptors, in the stomach respond to excess food intake, and their malfunction may play a role in the development of obesity, diabetes, and related metabolic conditions.
Drs. Sara Janssen and Inge Depoortere, of the Translational Research Center for Gastrointestinal Disorders at the Catholic University of Leuven, Belgium, examine this possibility, offering insights into the latest research on the topic. They say growing evidence suggests that obesity and related conditions might be prevented or treated by selective targeting of taste receptors on cells in the gut to release hormones that signal a feeling of fullness, thereby mimicking the physiological effects of a meal and fooling the body into thinking that it has eaten.
"The effectiveness of bariatric surgery to cause profound weight loss and a decrease in the prevalence of diabetes and other obesity-related conditions is not completely understood, but it may involve changes in the release of gut hormones," says Dr. Depoortere. "Targeting extraoral taste receptors that affect the release of hormones that control food intake may offer a new road to mimic these effects in a nonsurgical manner."
Additional studies are needed to show which gut taste receptors might be effective drug targets for the prevention and treatment of obesity and diabetes.
Cell Press: http://www.cellpress.com
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
The chytrid fungus has wiped out populations of amphibians around the world. A type of the fungus infects only salamanders, and researchers have identified vulnerable areas in North America.
NPR's Melissa Block speaks with the AP's Brazil bureau chief Brad Brooks about the investigation, which found high levels of dangerous viruses in water venues for the 2016 Summer Olympics.
Unusual clinical trial in Guinea offers promise for stopping epidemic
Researchers say study suggests need to target black men for screening of prostate cancer, which is projected to become the UK’s most common cancer by 2030 Black men in England have twice the lifetime risk of both being diagnosed with – and dying from – prostate cancer compared with white men, according to a study by Public Health England and Prostate Cancer UK.
MERS causes only mild symptoms in monkeys, so although the vaccine seemed to reduce their symptoms, it's hard to know if this will apply to humans as well
The World Health Organisation is doing its final checks and could declare Nigeria officially free of polio by September. Somalia could be next
Researchers in Hong Kong have cured infected monkeys of MERS using existing drugs
European Medicines Agency recommends RTS,S, or Mosquirix, developed by GSK and backed by Gates Foundation, for use in young children in Africa
Drought conditions in western states may be fueling the spread of this potentially deadly illness
Terminal cancer patients sometimes get chemotherapy in the belief that it will ease their symptoms. But a study finds many who get the treatment near death actually have a poorer quality of life.