Scientists at Karolinska Institutet in Sweden, in collaboration with colleagues in Germany and the Netherlands, have identified a previously unknown group of nerve cells in the brain. The nerve cells regulate cardiovascular functions such as heart rhythm and blood pressure. It is hoped that the discovery, which is published in the Journal of Clinical Investigation, will be significant in the long term in the treatment of cardiovascular diseases in humans.
The scientists have managed to identify in mice a previously totally unknown group of nerve cells in the brain. These nerve cells, also known as 'neurons', develop in the brain with the aid of thyroid hormone, which is produced in the thyroid gland. Patients in whom the function of the thyroid gland is disturbed and who therefore produce too much or too little thyroid hormone, thus risk developing problems with these nerve cells. This in turn has an effect on the function of the heart, leading to cardiovascular disease.
It is well-known that patients with untreated hyperthyroidism (too high a production of thyroid hormone) or hypothyroidism (too low a production of thyroid hormone) often develop heart problems. It has previously been believed that this was solely a result of the hormone affecting the heart directly. The new study, however, shows that thyroid hormone also affects the heart indirectly, through the newly discovered neurons.
"This discovery opens the possibility of a completely new way of combating cardiovascular disease", says Jens Mittag, group leader at the Department of Cell and Molecular Biology at Karolinska Institutet. "If we learn how to control these neurons, we will be able to treat certain cardiovascular problems like hypertension through the brain. This is, however, still far in the future. A more immediate conclusion is that it is of utmost importance to identify and treat pregnant women with hypothyroidism, since their low level of thyroid hormone may harm the production of these neurons in the foetus, and this may in the long run cause cardiovascular disorders in the offspring."
Karolinska Institutet: http://info.ki.se/ki
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Claims that Ai Hin was faking pregnancy to get better treatment have been debunked by leading panda expert
The recent release of Susan Greenfields new book and the film Lucy, both of which are dependent on tired misconceptions or dubious theories about the brain, suggest one worrying conclusion: we are running out of myths about the brain. So here are some new ones, to keep things mysterious
These are the siphonophores, some 180 known species of gelatinous strings that can grow to 100 feet long, making them some of the longest critters on the planet. But instead of growing as a single body like virtually every other animal, siphonophores clone themselves thousands of times over into half a dozen different types of specialized cloned bodies, all strung together to work as a team---a very deadly team at that.
Researchers who study memory have had a thrilling couple of years. Some have erased memories in people with electroshock therapy, for example. Others have figured out, in mice, how to create false memories and even turn bad memories into good ones.
Hunting bats don't just listen out for male frogs' mating calls: they can also use echolocation to detect when the frogs inflate their throat sacs
A crèche of 30 dinosaur infants looked over by an older animal shows that even terrible lizards needed a night away from the kids
Families have identifiable collections of microbes that travel with them. It can take just 24 hours for the microbes to take over a new house
When rabbits were domesticated, around 100 regions of their genome changed to make them less fearful, but the variations are not fixed
Scientists never understood what became of the Paleo-Eskimos who once peopled the north. Now they know—and there's new reason to miss them
NOAA whittles down initial list of 66 species to be covered by Endangered Species Act