Scientists observed that blocking the expression of the gene TRIP-Br2 in mice protects them against obesity and insulin resistance. The study shows that the gene modulates fat storage by regulating energy expenditure and lipolysis, the process which transforms fat into lipids for the body's energy consumption. If the gene expression is blocked, the mice increase their lipolysis and their energy expenditure, thus reducing their obesity.
Obesity is the result of an alteration in the processes that regulate food absorption and energy production. This alteration tips the balance towards excessive storage of fat. According to the researchers, understanding the regulation of the factors that control the storage, mobilisation and use of excess energy in fat cells (the adipocytes) can lead to the development of therapies for obesity and its related illnesses, such as type 2 diabetes.
In the words of Cristina Mallol, a researcher at the Universitat Autònoma de Barcelona and co-author of the study: "The protection of mice with no expression of the gene TRIP-Br2, and its selective elevation in the visceral fat of humans point the way to a future gene therapy to counteract obesity, insulin resistance and excess lipids in the blood".
Universitat Autonoma de Barcelona: http://www.uab.es
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
A wild male marmoset is filmed embracing and caring for his dying female partner.
A neuroscientist and a musician explain how they built the Brain Stethoscope, which is both brain scanner and musical instrument
Museum staff will ditch the bubble wrap in favor of custom-molded plaster cradles when shipping a Tyrannosaurus rex to Washington, D.C.
The direction you're moving can play tricks with your mind. That can mean trouble not only for travel but for human relations too
In Missing Microbes, Dr. Martin Blaser argues that the overuse of antibiotics, as well as now-common practices like C-sections, may be messing with gut microbes.
Scientists have figured out one reason women might be more vulnerable to Alzheimer's: A risk gene doubles women's chances of getting the disease but has minimal effect on men.
Harvestmen (also known as daddy long legs) aren’t spiders, and if you could (or wanted to) lean close enough, you’d be able to see one of the few physical features that distinguish them from their arachnid cousins. It’s in the eyes: Spiders usually have 6 or more, but the harvestman has only one set, tightly […]
Cuttlefish are far and away nature’s most adept camouflagers, capable of observing their surroundings and perfectly adjusting not only their color but also their skin texture in just 250 milliseconds. And it’s not just about blending in: They can also launch truly bizarre displays of rippling colors to either intimidate rivals or hypnotize prey. Oh, also. They’re color blind. Yeah … scientists aren’t quite sure how that’s possible quite yet.
Virtual records of fragile archaeological sites will preserve them for future generations when it's not possible to defend them from the elements
Holy Da Vinci Code! Chemical and epigraphic analyses suggest the "Gospel of Jesus's Wife" could be real.