National Institutes of Health (NIH) scientists have identified a promising lead for developing a new type of drug to treat infection caused by Staphylococcus aureus, a bacterium that frequently resists traditional antibiotics. The researchers discovered a system used by S. aureus to transport toxins that are thought to contribute to severe staph infections. These toxins—called phenol-soluble modulins (PSMs)—have gained much attention in recent years, but their multitude and diversity have hindered efforts to target them for drug development.
Expanding on work that first described S. aureus PSMs in 2007, scientists at the NIH's National Institute of Allergy and Infectious Diseases found that the transport system, which they call Pmt, is common to all S. aureus PSMs and critical for bacterial proliferation and disease development in a mouse model. Their experiments suggest that a drug interfering with Pmt's function could not only prevent production of the PSM toxins, but also directly lead to bacterial death.
Although their study focused on S. aureus, the scientists suspect that Pmt performs the same role in other staphylococci, such as S. epidermidis, the leading cause of hospital-associated infections involving indwelling medical devices such as catheters, pacemakers and prosthetics. They plan to continue their studies to improve the understanding of how PSMs function and to learn how to interfere with the Pmt transport system to block disease.
S Chatterjee et al. Essential Staphylococcus aureus toxin export system. Nature MedicineDOI: 10.1038/nm3047 (2013).
R Wang et al. Identification of novel cytolytic peptides as key virulence determinants of community-associated MRSA. Nature Medicine DOI: 10.1038/nm1656 (2007).
NIH/National Institute of Allergy and Infectious Diseases: http://www.niaid.nih.gov
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Claims that Ai Hin was faking pregnancy to get better treatment have been debunked by leading panda expert
The recent release of Susan Greenfields new book and the film Lucy, both of which are dependent on tired misconceptions or dubious theories about the brain, suggest one worrying conclusion: we are running out of myths about the brain. So here are some new ones, to keep things mysterious
These are the siphonophores, some 180 known species of gelatinous strings that can grow to 100 feet long, making them some of the longest critters on the planet. But instead of growing as a single body like virtually every other animal, siphonophores clone themselves thousands of times over into half a dozen different types of specialized cloned bodies, all strung together to work as a team---a very deadly team at that.
Researchers who study memory have had a thrilling couple of years. Some have erased memories in people with electroshock therapy, for example. Others have figured out, in mice, how to create false memories and even turn bad memories into good ones.
Hunting bats don't just listen out for male frogs' mating calls: they can also use echolocation to detect when the frogs inflate their throat sacs
A crèche of 30 dinosaur infants looked over by an older animal shows that even terrible lizards needed a night away from the kids
Families have identifiable collections of microbes that travel with them. It can take just 24 hours for the microbes to take over a new house
When rabbits were domesticated, around 100 regions of their genome changed to make them less fearful, but the variations are not fixed
Scientists never understood what became of the Paleo-Eskimos who once peopled the north. Now they know—and there's new reason to miss them
NOAA whittles down initial list of 66 species to be covered by Endangered Species Act