Since the beginning of time, living organisms have developed ingenious mechanisms to monitor their environment. As part of an international study, a team of researchers has adapted some of these natural mechanisms to detect specific molecules such as cocaine more accurately and quickly. Their work may greatly facilitate the rapid screening—less than five minutes—of many drugs, infectious diseases, and cancers.
Professor Alexis Vallée-Bélisle of the University of Montreal Department of Chemistry has worked with Professor Francesco Ricci of the University of Rome Tor Vergata and Professor Kevin W. Plaxco of the University of California at Santa Barbara to improve a new biosensing nanotechnology. The results of the study were recently published in the Journal of American Chemical Society (JACS).
Toward a new generation of screening tests
"Nature is a continuing source of inspiration for developing new technologies," says Professor Francesco Ricci, senior author of the study. "Many scientists are currently working to develop biosensor technology to detect—directly in the bloodstream and in seconds—drug, disease, and cancer molecules."
"The most recent rapid and easy-to-use biosensors developed by scientists to determine the levels of various molecules such as drugs and disease markers in the blood only do so when the molecule is present in a certain concentration, called the concentration window," adds Professor Vallée-Bélisle. "Below or above this window, current biosensors lose much of their accuracy."
To overcome this limitation, the international team looked at nature: "In cells, living organisms often use inhibitor or activator molecules to automatically program the sensitivity of their receptors (sensors), which are able to identify the precise amount of thousand of molecules in seconds," explains Professor Vallée-Bélisle. "We therefore decided to adapt these inhibition, activation, and sequestration mechanisms to improve the efficiency of artificial biosensors."
The researchers put their idea to the test by using an existing cocaine biosensor and revising its design so that it would respond to a series of inhibitor molecules. They were able to adapt the biosensor to respond optimally even with a large concentration window. "What is fascinating," says Alessandro Porchetta, a doctoral student at the University of Rome, "is that we were successful in controlling the interactions of this system by mimicking mechanisms that occur naturally."
"Besides the obvious applications in biosensor design, I think this work will pave the way for important applications related to the administration of cancer-targeting drugs, an area of increasing importance," says Professor Kevin Plaxco. "The ability to accurately regulate biosensor or nanomachine's activities will greatly increase their efficiency."
University of Montreal: http://bit.ly/mNqklw
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Institute for Highway Safety is known for crash-test safety ratings, but as cars get smarter there's a need to look beyond crashworthiness
Researchers have long struggled to resolve what happens to information when it falls inside a black hole, but the famous physicist says he has a solution
Researchers have been using muons to take a peek inside the nuclear reactors in Japan that melted down in 2011. The results could aid the continuing cleanup operations.
Neutrinos, created by violent phenomena such as black holes and exploding stars, could hold the key to the universe’s most distant and mysterious events
Better MRI scanners could result from a trick in which a magnetic field springs up from nowhere, using materials famous for their link to invisibility cloaks
Water locked away in rocks for 1.5 billion years reveals conditions were right for complex organic molecules to form in deep sea hydrothermal vents
Helium, used in nuclear, medical and, yes, party industries, has become scarce, but new research has revealed a possible way to pinpoint fresh sources
New lab results show how collisions between comets and planets can make the molecules that are the essential building blocks of life.
A startup company says it is expanding the language of DNA to create new tools for drug discovery.
If scientists can convince people to use the app, they hope it will help them solve a cosmic mystery. This story originally aired on March 27, 2015 on All Things Considered.