The most common genetic cause of Parkinson's is not only responsible for the condition's distinctive movement problems but may also affect vision, according to new research by scientists at the University of York.
Parkinson's, the second most common form of neurodegenerative disease, principally affects people aged over 60. Its most common symptom is tremor and slowness of movement (bradykinesia) but some people with Parkinson's also experience changes in vision.
Now for the first time, researchers in the University's Department of Biology have established a link between a mutation which triggers Parkinson's and problems with vision in an animal model.
The latest research, part-funded by leading research charity Parkinson's UK is published in Human Molecular Genetics. Scientists at York studied the impact of the most common Parkinson's-related mutation on nerve cells in the visual system of the fruit fly, Drosophila.
Using electroretinagram (ERG) technology they found a gradual loss of function in eye nerve cells with the mutant gene. The fly visual system is a useful laboratory model as it contains similar amounts of dopamine to the human eye.
However, the research team, which was supported by the University's Centre for Chronic Disease and Disorders (C2D2), found that other Parkinson's-related mutations did not affect eye nerve cell function and there was no loss of vision.
Dr Chris Elliott, who led the research, said: "This is a significant step forward as it will help to identify those people with Parkinson's who may be at greater risk of changes in their vision. It will assist clinicians to manage the condition more effectively.
"We have to get away from the idea that Parkinson's is only about movement problems. This work indicates that changes in vision may also affect people with the most common form of inherited Parkinson's."
Claire Bale, Research Communications Manager at Parkinson's UK added: "This new research has uncovered a potentially interesting relationship between one of the most common genes linked to Parkinson's and the development of visual problems.
"But crucially this study looked at fruit flies, so we need to do more research to find out how relevant the findings are to people living with the condition.
"If you have Parkinson's and notice changes in your eyesight, such as blurred or double vision, it's important to discuss this with your specialist or Parkinson's nurse."
University of York: http://www.york.ac.uk
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
A veteran EMT and ambulance driver in Boston, Ed McCarthy is in a great position to understand his hometown spatially. But he’s also a history geek, and while constantly driving around the city’s neighborhoods, he loves recognizing the streets, buildings and other locales from the history books he so often buries his nose in.
The extinction of the biggest shark known to science may have triggered whales to grow to their current hefty sizes, a study suggests.
The UK's chief scientist says the oceans face a serious and growing risk from man-made carbon emissions.
Modifying neurons to flash as electrical impulses pass along them lets researchers grow light-up brains in a dish and eavesdrop on their chatter
They lived on a remote dot of land in the middle of the Pacific, 2,300 miles (3,700 km) west of South America and 1,100 miles (1,770 km) from the closest island, erecting huge stone figures that still stare enigmatically from the hillsides.
In a bleak, treeless landscape high in the southern Peruvian Andes, bands of intrepid Ice Age people hunkered down in rudimentary dwellings and withstood frigid weather, thin air and other hardships.
A viral video shows people lauding fare billed as an "organic" fast-food option that was actually McDonald's. It wasn't just pranksters playing tricks on these poor folks, but maybe their brains, too.
Deinocheirus mirificus, or unusual horrible hand, had long, clawed forearms, a sail on its back and a duck-like bill
Open letter says claims made for brain games are not based on sound evidence and that playing them may have opposite effect
A significant Bronze Age pottery find is made during an archaeological dig on the east side of Lewis, in Scotland.