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Research provides new clues on how ApoE4 affects Alzheimer's risk

Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear. Now, researchers funded by the National Institutes of Health have found that in mice, having the most risky variant of ApoE damages the blood vessels that feed the brain.

Neuroscience | Source: NIH/National Institute of Neurological Disorders and Stroke | Views: 59 | Comments: 0
Paralyzed individuals use thought-controlled robotic arm to reach and grasp

In an ongoing clinical trial, a paralyzed woman was able to reach for and sip from a drink on her own – for the first time in nearly 15 years – by using her thoughts to direct a robotic arm. The trial, funded in part by the National Institutes of Health, is evaluating the safety and feasibility of an investigational device called the BrainGate neural interface system. This is a type of brain-com

Neuroscience | Source: NIH/National Institute of Neurological Disorders and Stroke | Views: 73 | Comments: 0
Stabilizing Fanconi anemia with antioxidants

Fanconi anemia (FA) is a rare genetic disorder which affects one person in 350,000. People affected by this disease have defects in DNA repair, and are hypersensitive to oxidative damage, resulting in bone marrow failure and an increased predisposition to cancer. New research published in BioMed Central's open access journal Orphanet Journal of Rare Diseases shows that a combination of the

Marine Biology | Source: BioMed Central | Views: 123 | Comments: 0
Team discovers unexpected source of diabetic neuropathy pain

Nearly half of all diabetics suffer from neuropathic pain, an intractable, agonizing and still mysterious companion of the disease. Now Yale researchers have identified an unexpected source of the pain and a potential target to alleviate it.

Neuroscience | Source: Yale University | Views: 51 | Comments: 0
Mixed bacterial communities evolve to share resources, not compete

New research shows how bacteria evolve to increase ecosystem functioning by recycling each other's waste. The study provides some of the first evidence for how interactions between species shape evolution when there is a diverse community.

Microbiology | Source: Public Library of Science | Views: 58 | Comments: 0
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Mixed bacterial communities evolve to share resources, not compete

New research shows how bacteria evolve to increase ecosystem functioning by recycling each other's waste. The study provides some of the first evidence for how interactions between species shape evolution when there is a diverse community.

Microbiology | Source: Public Library of Science | Views: 58 | Comments: 0
Drugs from lizard saliva reduces the cravings for food

A drug made from the saliva of the Gila monster lizard is effective in reducing the craving for food. Researchers at the Sahlgrenska Academy, University of Gothenburg, have tested the drug on rats, who after treatment ceased their cravings for both food and chocolate.

Neuroscience | Source: University of Gothenburg | Views: 101 | Comments: 0
New evidence that many genes of small effect influence economic decisions and political attitudes

Genetic factors explain some of the variation in a wide range of people's political attitudes and economic decisions – such as preferences toward environmental policy and financial risk taking – but most associations with specific genetic variants are likely to be very small, according to a new study led by Cornell University economics professor Daniel Benjamin.

Genetics | Source: Cornell University | Views: 69 | Comments: 0
Mystery gene reveals new mechanism for anxiety disorders

A novel mechanism for anxiety behaviors, including a previously unrecognized inhibitory brain signal, may inspire new strategies for treating psychiatric disorders, University of Chicago researchers report.

Genetics | Source: University of Chicago Medical Center | Views: 56 | Comments: 0
Nerve transfers restore hand function after cervical spinal cord injury

A plastic surgeon and neurosurgeon at Washington University School of Medicine in St. Louis were successful in using peripheral nerve transfer to bypass a cervical spinal cord injury and restore partial function in both hands in a 71-year-old man. To the authors' knowledge, this is the first report of reactivation of muscles in thumb and fingers after spinal cor

Neuroscience | Source: Journal of Neurosurgery Publishing Group | Views: 65 | Comments: 0
Mice with big brains provide insight into brain regeneration and developmental disorders

Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) have discovered that mice that lack a gene called Snf2l have brains that are 35 per cent larger than normal. The research, led by Dr. David Picketts and published in the prestigious journal Developmental Cell, could lead to new approaches to stimulate brain regeneration and may provide importa

Neuroscience | Source: Ottawa Hospital Research Institute | Views: 40 | Comments: 0
Delivery system for gene therapy may help treat arthritis

A DNA-covered submicroscopic bead used to deliver genes or drugs directly into cells to treat disease appears to have therapeutic value just by showing up, researchers report.

Immunology | Source: Georgia Health Sciences University | Views: 62 | Comments: 0
Scientists successfully test the first gene therapy against aging-associated decline in animal model

A number of studies have shown that it is possible to lengthen the average life of individuals of many species, including mammals, by acting on specific genes. To date, however, this has meant altering the animals' genes permanently from the embryonic stage – an approach impracticable in humans. Researchers at the Spanish National Cancer Research Centre (CNIO), led by its director María Blasco, ha

Genetics | Source: Centro Nacional de Investigaciones Oncologicas (CNIO) | Views: 102 | Comments: 0
Work may improve the efficiency of the biofuel production cycle

By deciphering the makeup of a bacterium found in the soil of a tropical rain forest, scientists may have a better understanding of how to more efficiently produce biofuels.

Microbiology | Source: DOE/Lawrence Livermore National Laboratory | Views: 59 | Comments: 0
Genes underlying the key domestication process in sorghum and other cereals

A study by a team of university and government scientists led by a Kansas State University researcher, indicates that genes responsible for seed shattering -- the process by which grasses disseminate their seeds -- were under parallel selection during sorghum, rice and maize domestication.

Genetics | Source: Kansas State University | Views: 91 | Comments: 0
Research opens doors to UV disinfection using LED technology

Research from North Carolina State University will allow the development of energy-efficient LED devices that use ultraviolet (UV) light to kill pathogens such as bacteria and viruses. The technology has a wide array of applications ranging from drinking-water treatment to sterilizing surgical tools.

Microbiology | Source: North Carolina State University | Views: 91 | Comments: 0
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