Posted by: Jon Moulton
Posted on: Fri, May 09, 2014, 11:19 am CDT

Michel M, Wilhelmi I, Schultz A-S, Preussner M, Heyd F. Activation-induced Tumor Necrosis Factor Receptor-associated Factor 3 (Traf3) Alternative Splicing Controls the Noncanonical Nuclear Factor κB Pathway and Chemokine Expression in Human T Cells. J Biol Chem. 2014;289:13651-60. doi:10.1074/jbc.M113.526269

 

Morpholino oligos inducing alternative splicing in T-cells.  Delivery in jsl1 t-cell culture by electroporation.  "Furthermore, the interferon response, which can be regulated by Traf3 (35), was not altered in Traf3E8 MO-treated cells (data not shown)" supports lack of Morpholino-induced innate immunity.