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New mechanism discovered in meiosis
The Research Group headed by molecular biologist Andrea Pichler from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has made an important discovery in meiosis research. Pichler and her group have identified a new mechanism that plays an important role in meiosis.
Molecular Biology
Source: Max-Planck-Gesellschaft
Posted on: Monday, May 06, 2013, 10:00am
Rating: | Views: 1634 | Comments: 0
Ebola's secret weapon revealed
Researchers have discovered the mechanism behind one of the Ebola virus' most dangerous attributes: its ability to disarm the adaptive immune system.
Molecular Biology
Source: University of Texas Medical Branch at Galveston
Posted on: Friday, May 03, 2013, 1:45pm
Rating: | Views: 1852 | Comments: 0
Botox finds new wrinkle in brain communication
National Institutes of Health researchers used the popular anti-wrinkle agent Botox to discover a new and important role for a group of molecules that nerve cells use to quickly send messages. This novel role for the molecules, called SNARES, may be a missing piece that scientists have been searching for to fully understand how brain cells communicate under normal and disease conditions.
Molecular Biology
Source: NIH/National Institute of Neurological Disorders and Stroke
Posted on: Friday, May 03, 2013, 12:30pm
Rating: | Views: 3522 | Comments: 0
'Dark genome' is involved in Rett Syndrome
Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding long chain RNA sequences (lncRNA) in Rett syndrome.
Molecular Biology
Source: IDIBELL-Bellvitge Biomedical Research Institute
Posted on: Friday, May 03, 2013, 12:15pm
Rating: | Views: 1893 | Comments: 0
Scientists create genetically altered mice to model human disease
Whitehead Institute Founding Member Rudolf Jaenisch, who helped transform the study of genetics by creating the first transgenic mouse in 1974, is again revolutionizing how genetically altered animal models are created and perhaps even redefining what species may serve as models.
Molecular Biology
Source: Whitehead Institute for Biomedical Research
Posted on: Friday, May 03, 2013, 11:30am
Rating: | Views: 1796 | Comments: 0
It slices, it dices, it silences: ADAR1 as gene-silencing modular RNA multitool
RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics. In a study presented in the April 25 issue of the journal Cell, researchers from The Wistar Institute discovered how the RNA-editing protein, ADAR1, also combines with the protein called Dicer to create microRNA (miRNA) and small interfering (siRN
Molecular Biology
Source: The Wistar Institute
Posted on: Thursday, May 02, 2013, 4:00pm
Rating: | Views: 5943 | Comments: 0
New molecule heralds hope for muscular dystrophy treatment
There's hope for patients with myotonic dystrophy. A new small molecule developed by researchers at the University of Illinois has been shown to break up the protein-RNA clusters that cause the disease in living human cells, an important first step toward developing a pharmaceutical treatment for the as-yet untreatable disease.
Molecular Biology
Source: University of Illinois at Urbana-Champaign
Posted on: Thursday, May 02, 2013, 2:00pm
Rating: | Views: 1663 | Comments: 0
Membrane remodeling: Where yoga meets cell biology
Cells ingest proteins and engulf bacteria by a gymnastic, shape-shifting process called endocytosis. Researchers at the National Institutes of Health revealed how a key protein, dynamin, drives the action.
Molecular Biology
Source: NIH/National Institute of General Medical Sciences
Posted on: Wednesday, May 01, 2013, 2:15pm
Rating: | Views: 1660 | Comments: 0
Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies
A new use for compounds related in composition to the active ingredient in marijuana may be on the horizon: a new research report published in the Journal of Leukocyte Biology shows that compounds that stimulate the cannabinoid type 2 (CB2) receptor in white blood cells, specifically macrophages, appear to weaken HIV-1 infection. The CB2 receptor is the molecular link through which the pha
Molecular Biology
Source: Federation of American Societies for Experimental Biology
Posted on: Wednesday, May 01, 2013, 11:45am
Rating: | Views: 1637 | Comments: 0
Hitting 'reset' in protein synthesis restores myelination
A potential new treatment strategy for patients with Charcot-Marie-Tooth disease is on the horizon, thanks to research by neuroscientists now at the University at Buffalo's Hunter James Kelly Research Institute and their colleagues in Italy and England.
Molecular Biology
Source: University at Buffalo
Posted on: Monday, Apr 29, 2013, 10:45am
Rating: | Views: 1531 | Comments: 0
Protein shaped like a spider
The protein C4BP is similar to a spider in its spatial form with eight "arms". The structure of the "spider body" has recently been described in detail by researchers from the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Technische Universität Darmstadt. This leads the scientists to unconventional ideas – the protein is possibly suitable as a scaffold for the transport of
Molecular Biology
Source: Helmholtz Centre for Infection Research
Posted on: Monday, Apr 29, 2013, 10:15am
Rating: | Views: 1499 | Comments: 0
Researchers identify key cellular organelle involved in gene silencing
RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes — from development to physiology to stress response.
Molecular Biology
Source: University of California - Riverside
Posted on: Friday, Apr 26, 2013, 1:30pm
Rating: | Views: 2058 | Comments: 0
Pushing the boundaries of transcription
Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cel
Molecular Biology
Source: European Molecular Biology Laboratory
Posted on: Friday, Apr 26, 2013, 1:15pm
Rating: | Views: 1547 | Comments: 0
Discovery of a gene that controls 3 different diseases
An international research consortium led by the Universitat Autònoma de Barcelona (UAB), the CIBERER and the University of Wurzburg (Germany) has discovered a gene that can cause three totally different diseases, depending on how it is altered.
Molecular Biology
Source: Universitat Autonoma de Barcelona
Posted on: Friday, Apr 26, 2013, 12:30pm
Rating: | Views: 1737 | Comments: 0
Link between inherited endocrine tumor syndrome and much-studied cell pathway
A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1). Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin.
Molecular Biology
Source: University of Pennsylvania School of Medicine
Posted on: Thursday, Apr 25, 2013, 1:30pm
Rating: | Views: 1519 | Comments: 0
Scientists find antibody that transforms bone marrow stem cells directly into brain cells
In a serendipitous discovery, scientists at The Scripps Research Institute (TSRI) have found a way to turn bone marrow stem cells directly into brain cells.
Molecular Biology
Source: Scripps Research Institute
Posted on: Tuesday, Apr 23, 2013, 11:15am
Rating: | Views: 1397 | Comments: 0
New light shed on early stage Alzheimer's disease
The disrupted metabolism of sugar, fat and calcium is part of the process that causes the death of neurons in Alzheimer's disease. Researchers from Karolinska Institutet in Sweden have now shown, for the first time, how important parts of the nerve cell that are involved in the cell's energy metabolism operate in the early stages of the disease. These somewhat surprising results shed new light on
Molecular Biology
Source: Karolinska Institutet
Posted on: Tuesday, Apr 23, 2013, 11:00am
Rating: | Views: 1839 | Comments: 0
A check on tension
Ludwig researchers Arshad Desai and Christopher Campbell, a post-doctoral fellow in his laboratory, were conducting an experiment to parse the molecular details of cell division about three years ago, when they engineered a mutant yeast cell as a control that, in theory, had no chance of surviving. Apparently unaware of this, the mutant thrived.
Molecular Biology
Source: Ludwig Institute for Cancer Research
Posted on: Monday, Apr 22, 2013, 2:45pm
Rating: | Views: 1482 | Comments: 0
Same protein that fires up cancer-promoting Erk also blocks its activation
A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology.
Molecular Biology
Source: University of Texas M. D. Anderson Cancer Center
Posted on: Monday, Apr 22, 2013, 1:15pm
Rating: | Views: 1408 | Comments: 0
Random walks on DNA
Scientists have revealed how a bacterial enzyme has evolved an energy-efficient method to move long distances along DNA. The findings, published in Science, present further insight into the coupling of chemical and mechanical energy by a class of enzymes called helicases, a widely-distributed group of proteins, which in human cells are implicated in some cancers.
Molecular Biology
Source: University of Bristol
Posted on: Monday, Apr 22, 2013, 10:30am
Rating: | Views: 1600 | Comments: 0
A surprising new function for small RNAs in evolution
It has long been known that certain proteins, known as transcription factors, directly control the way in which information is read from DNA. As a result, it is widely believed that changes in genes encoding such proteins underlie the mechanisms responsible for evolutionary adaptation. The idea that small RNA molecules, so-called microRNAs, may play an important part in evolutionary changes to a
Molecular Biology
Source: University of Veterinary Medicine -- Vienna
Posted on: Friday, Apr 19, 2013, 2:15pm
Rating: | Views: 1952 | Comments: 0
Researchers discover that stem cell senescence drives aging
Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor or stem cells -- important for repair and regeneration of skeletal muscle and maintenance of healthy fat tissue -- are subject to cellular senescence,
Molecular Biology
Source: Mayo Clinic
Posted on: Friday, Apr 19, 2013, 12:00pm
Rating: | Views: 3633 | Comments: 0
New stem cell-based screen reveals promising drug for Lou Gehrig's disease
Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a fatal disease that causes motor neurons, which are responsible for controlling muscles, to die. A study published by Cell Press on April 18th in Cell Stem Cell has revealed a novel stem-cell-based approach to screen for effective treatments, which are sorely lacking. Applying this method to motor neurons derived fro
Molecular Biology
Source: Cell Press
Posted on: Friday, Apr 19, 2013, 11:30am
Rating: | Views: 1461 | Comments: 0
Discovery may help prevent HIV 'reservoirs' from forming
Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the protein that blocks HIV-1 from multiplying in white blood cells is regulated. HIV-1 is the virus that causes AIDS, and the discovery could lead to novel approaches for addressing HIV-1 "in hiding" – namely eliminating reservoirs of HIV-1 that persist in patients undergoin
Molecular Biology
Source: Albert Einstein College of Medicine
Posted on: Thursday, Apr 18, 2013, 1:30pm
Rating: | Views: 1448 | Comments: 0
Recipe for large numbers of stem cells requires only one ingredient
Stem cells and tissue-specific cells can be grown in abundance from mature mammalian cells simply by blocking a certain membrane protein, according to scientists at the University of Pittsburgh School of Medicine and the National Institutes of Health (NIH). Their experiments, reported today in Scientific Reports, also show that the process doesn't require other kinds of cells or agents to a
Molecular Biology
Source: University of Pittsburgh Schools of the Health Sciences
Posted on: Wednesday, Apr 17, 2013, 2:15pm
Rating: | Views: 1432 | Comments: 0
Transcription factors regulating blood oxygen linked to melanoma metastases
Researchers at the University of North Carolina have discovered that transcription factors regulating the levels of oxygen in the blood also play a role in the spread of the skin cancer melanoma.
Molecular Biology
Source: University of North Carolina Health Care
Posted on: Wednesday, Apr 17, 2013, 11:00am
Rating: | Views: 1496 | Comments: 0
Cancer cell metabolism kills
ATP is the main energy currency of cells and one might expect that not only contracting muscle, but also uncontrollably dividing cancer cells would have a high demand for ATP. However, for some reason cancer cells have re-programmed their metabolic engines to produce less ATP. The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cance
Molecular Biology
Source: University of Helsinki
Posted on: Tuesday, Apr 16, 2013, 11:00am
Rating: | Views: 1670 | Comments: 0
The tulip tree reveals mitochondrial genome of ancestral flowering plant
The extraordinary level of conservation of the tulip tree (Liriodendron tulipifera) mitochondrial genome has redefined our interpretation of evolution of the angiosperms (flowering plants), finds research in biomed Central's open access journal BMC Biology. This beautiful 'molecular fossil' has a remarkably slow mutation rate meaning that its mitochondrial genome has remained largely
Plant Biology
Source: BioMed Central
Posted on: Monday, Apr 15, 2013, 1:15pm
Rating: | Views: 1932 | Comments: 0
Healing by the clock
Circadian rhythms keep time for all living things, from regulating when plants open their flowers to foiling people when they try to beat jet lag. Day-night cycles are controlled through ancient biological mechanisms, evolutionarily speaking, so in essence, a human has the same internal clock as a fly does.
Molecular Biology
Source: Harvard Medical School
Posted on: Friday, Apr 12, 2013, 1:45pm
Rating: | Views: 1382 | Comments: 0
Cell-destroyer that fights and promotes TB reveals what's behind its split identity
Tumor necrosis factor – normally an infection-fighting substance produced by the body– can actually heighten susceptibility to tuberculosis if its levels are too high.
Molecular Biology
Source: University of Washington
Posted on: Friday, Apr 12, 2013, 1:15pm
Rating: | Views: 1477 | Comments: 0
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