People who have been diagnosed with MGUS Monoclonal gammopathy of undetermined significance
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Monoclonal gammopathy of undetermined significance
Classification and external resources
Schematic representation of a normal protein electrophoresis gel. A small spike would be present in the gamma (γ) band in MGUS
Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted for undetermined), formerly benign monoclonal gammopathy, is a condition in which a paraprotein is found in the blood during standard laboratory tests. It resembles multiple myeloma and similar diseases, but the levels of antibody are lower, the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, it has no symptoms or problems, and no treatment is indicated. However, multiple myeloma develops at the rate of about 1-2% a year, so doctors recommend monitoring it yearly. In rare cases, it may also be related with a slowly progressive symmetric distal sensorimotor neuropathy.
Increased serum protein with M spike. Other typical features seen in multiple myeloma are absent, such as hypercalcemia, lytic bone lesions, Bence Jones proteinuria, and AL amyloid. Commonly seen in elderly.