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Sigmund Lab
Lab Information
University of Iowa
Lab Description:
1) Tissue Renin-Angiotensin Systems in Blood Pressure Regulation
2) Molecular Mechanisms Regulating Renin Gene Expression
3) Physiological Significance of Genetic Variation in the Human Genome
4) Role of PPARgamma in Hypertension and Vascular Function

Lab Grants:
R37 MERIT HL48058-10
Project Title: Role of Enhancers Regulating Renin Gene Expression

R01 HL61446-07
Project Title: Significance of Angiotensinogen Variants in Hypertension

R01 HL76421-03
Project Title: Significance of Genetic Variation in NOS3 and SOD3 Genes

P01 NS24621-16
PPG Title: Cerebral Vascular Biology Program Project Grant
Project 4 Title: Protective Mechanisms in the Cerebral Vascular Wall: Role of PPARg

P01 HL62984-06
Oxidative Mechanisms in Vascular Disease
Project 4 Title: Identification and Function of PPARĪ³ and PPARĪ³
Target Genes in the Blood Vessel
Lab Members (1) See all?

Eric Weatherford
Graduate Student PhD
Desch M Schreiber A Schweda F Madsen K Friis UG Weatherford ET Sigmund CD Sequeira Lopez ML Gomez RA Todorov VT. 2010. Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells..Hypertension. 55:660-6
Sequeira-Lopez ML Weatherford ET Borges GR Monteagudo MC Pentz ES Harfe BD Carretero O Sigmund CD Gomez RA. 2010. The microRNA-processing enzyme dicer maintains juxtaglomerular cells..J. Am. Soc. Nephrol.. 21:460-7
Zhou X Weatherford ET Liu X Born E Keen HL Sigmund CD. 2008. Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus..Am. J. Physiol. Renal Physiol.. 295:F642-53
Weatherford ET, Itani H, Keen HL, Sigmund CD.. 2007. Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin?.Hypertension. 50:844-846