Sigmund Lab
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Lab Information
University of Iowa Lab Description:
1) Tissue Renin-Angiotensin Systems in Blood Pressure Regulation
2) Molecular Mechanisms Regulating Renin Gene Expression
3) Physiological Significance of Genetic Variation in the Human Genome
4) Role of PPARgamma in Hypertension and Vascular Function
Lab Grants:
R37 MERIT HL48058-10
1/1/2006-11/30/2010
Project Title: Role of Enhancers Regulating Renin Gene Expression
R01 HL61446-07
7/1/2004-6/30/2009
Project Title: Significance of Angiotensinogen Variants in Hypertension
R01 HL76421-03
4/1/2004-3/31/2008
Project Title: Significance of Genetic Variation in NOS3 and SOD3 Genes
P01 NS24621-16
2/1/2002-1/31/2007
PPG Title: Cerebral Vascular Biology Program Project Grant
Project 4 Title: Protective Mechanisms in the Cerebral Vascular Wall: Role of PPARg
P01 HL62984-06
4/1/2006-3/30/2011
Oxidative Mechanisms in Vascular Disease
Project 4 Title: Identification and Function of PPARĪ³ and PPARĪ³
Target Genes in the Blood Vessel
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Lab Members (1) See all?
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Publications
Sequeira-Lopez ML Weatherford ET Borges GR Monteagudo MC Pentz ES Harfe BD Carretero O Sigmund CD Gomez RA. 2010. The microRNA-processing enzyme dicer maintains juxtaglomerular cells..J. Am. Soc. Nephrol.. 21:460-7
Desch M Schreiber A Schweda F Madsen K Friis UG Weatherford ET Sigmund CD Sequeira Lopez ML Gomez RA Todorov VT. 2010. Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells..Hypertension. 55:660-6
Zhou X Weatherford ET Liu X Born E Keen HL Sigmund CD. 2008. Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus..Am. J. Physiol. Renal Physiol.. 295:F642-53
Weatherford ET, Itani H, Keen HL, Sigmund CD.. 2007. Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin?.Hypertension. 50:844-846
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