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Marshall Lab
Lab Information
Lab Description:
Our lab is interested in the engineering design principles that underly cellular morphogenesis. We want to understand how the three-dimensional geometry of cells can be encoded in a one-dimensional genome and developed into varying cellular architectures under genetic control. We are investigating this question at the level of individual organelles (centrioles, cilia, and mitochondria) as well as through studies of the overall architecture of cells. We are particularly interested in the control of organelle size and copy number, and in the role of biological self-replication processes. Our lab uses a combination of genomic, proteomic, imaging, and mathematical modeling approaches.
Lab Members (1) See all?
Rasi MQ Parker JD Feldman JL Marshall WF Quarmby LM. 2009. Katanin knockdown supports a role for microtubule severing in release of basal bodies before mitosis in Chlamydomonas..Mol. Biol. Cell. 20:379-88
Marshall WF. 2009. Chapter 1 Basal bodies platforms for building cilia..Curr. Top. Dev. Biol.. 85:1-22
Marshall WF. 2009. Quantitative high-throughput assays for flagella-based motility in chlamydomonas using plate-well image analysis and transmission correlation spectroscopy..Curr. Biol.. 14:133-41
Feldman JL Marshall WF. 2009. ASQ2 encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation..Curr. Biol.. 19:1238-43
Keller LC Geimer S Romijn E Yates J Zamora I Marshall WF. 2008. Molecular Architecture of the Centriole Proteome: The Conserved WD40 Domain Protein POC1 Is Required for Centriole Duplication and Length Control..Mol. Biol. Cell. 85:1-22
Marshall WF. 2008. The cell biological basis of ciliary disease..J. Cell Biol.. 180:17-21
Marshall WF Kintner C. 2008. Cilia orientation and the fluid mechanics of development..Curr. Opin. Cell Biol.. 20:48-52
Keller LC Marshall WF. 2008. Isolation and proteomic analysis of Chlamydomonas centrioles..Methods Mol. Biol.. 432:289-300
Marshall WF. 2008. Use of transcriptomic data to support organelle proteomic analysis..Methods Mol. Biol.. 432:403-14
Rafelski SM Marshall WF. 2008. Building the cell: design principles of cellular architecture..Nat. Rev. Mol. Cell Biol.. 9:593-602
Marshall WF. 2008. Engineering design principles for organelle size control systems..Semin. Cell Dev. Biol.. 19:520-4
Marshall WF. 2008. Modeling recursive RNA interference..PLoS Comput. Biol.. 4:e1000183
Marshall WF. 2008. Controlling size within cells..Semin. Cell Dev. Biol.. 19:479
Marshall WF. 2007. Centriole assembly: the origin of nine-ness..Curr. Biol.. 17:R1057-9
Wemmer KA Marshall WF. 2007. Flagellar length control in chlamydomonas--paradigm for organelle size regulation..Int. Rev. Cytol.. 260:175-212
Marshall WF. 2007. Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance..Biophys. J.. 93:1818-33
Feldman JL Geimer S Marshall WF. 2007. The mother centriole plays an instructive role in defining cell geometry..PLoS Biol.. 5:e149
Marshall WF Nonaka S. 2006. Cilia: tuning in to the cell's antenna..Curr. Biol.. 16:R604-14
Mogilner A Wollman R Marshall WF. 2006. Quantitative modeling in cell biology: what is it good for?.Dev. Cell. 11:279-87
Marshall WF. 2006. What is the function of centrioles?.J. Cell. Biochem.. 100:916-22