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Press Release
Scientists demystify an enzyme responsible for drug and food metabolism


Thanks to Penn State for this article.

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Comments

Prabodh Kandala
Texas Tech University Health Science Center
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Mon, Nov 15, 2010, 7:53 am CST

Woww, thats a blast.

Definitely great science.

I guess, this work will be in race for Nobel


Will
UC Davis
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Tue, Nov 16, 2010, 5:54 pm CST

I'm not sure I understand why this enzyme has such a short half life though?  I can understand not wanting to waste energy by having it on all the time, but since it is such a crucial factor in drug metabolism why would it not stay activated for longer...


biochem belle
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Tue, Nov 16, 2010, 7:09 pm CST

It's not that the enzyme has a short half-life. It's that the active intermediate is short-lived. The intermediate can be quickly regenerated, but keeping a short half-life prevents it from generating reactive oxygen species that can cause protein, RNA, or DNA damage.

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