A University of British Columbia researcher has helped create a gel – based on the mussel's knack for clinging to rocks, piers and boat hulls – that can be painted onto the walls of blood vessels and stay put, forming a protective barrier with potentially life-saving implications.
Co-invented by Assistant Professor Christian Kastrup while a postdoctoral student at the Massachusetts Institute of Technology, the gel is similar to the amino acid that enables mussels to resist the power of churning water. The variant that Kastrup and his collaborators created, described in the current issue of the online journal PNAS Early Edition, can withstand the flow of blood through arteries and veins.
The gel's "sheer strength" could shore up weakened vessel walls at risk of rupturing – much like the way putty can fill in dents in a wall, says Kastrup, a member of the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories.
By forming a stable barrier between blood and the vessel walls, the gel could also prevent the inflammation that typically occurs when a stent is inserted to widen a narrowed artery or vein; that inflammation often counteracts the opening of the vessel that the stent was intended to achieve.
The widest potential application would be preventing the rupture of blood vessel plaque. When a plaque ruptures, the resulting clot can block blood flow to the heart (triggering a heart attack) or the brain (triggering a stroke). Mice treated with a combination of the gel and an anti-inflammatory steroid had more stable plaque than a control group of untreated mice.
"By mimicking the mussel's ability to cling to objects, we created a substance that stays in place in a very dynamic environment with high flow velocities," says Kastrup, a member of UBC's Centre for Blood Research.
University of British Columbia: http://www.ubc.ca
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
A playfully named subatomic particle is confirmed, and beats rivals Bert and Ernie in terms of energy. Next step: to find a cluster of space neutrinos
Can matter be made of four quarks bound together? The discovery of a new particle has been confirmed at the LHC and may be our best hope of an answer
Traditional spice producers and synthetic biologists don't have to compete – there's room for both
Cortines School's Greg Schiller was removed by L.A. Unified after two students' projects were deemed to resemble weapons. A popular Los Angeles high school science teacher has been suspended after students turned in projects that appeared dangerous to administrators, spurring a campaign calling for his return to the classroom.
Eighty percent of the universe is utterly invisible, but an exotic dance of mutually annihilating particles may explain it all
NASA says the Western Pacific island of Nishino-shima has merged with its newly created volcanic companion, forming one larger landmass.
Scientist Lawrence Krauss says clips of him were "mined" to lend credibility to The Principle, a film he describes as "stupid" and "unbelievable."
An experiment located at the bottom of a US gold mine could offer the best chance yet of detecting dark matter, scientists believe.
The U.S. Navy is planning sea trials for a weapon that can fire a low-cost, 23-pound (10-kg) projectile at seven times the speed of sound using electromagnetic energy, a "Star Wars" technology that will make enemies think twice, the Navy's research chief said.
A spectacular satellite view of China's Piqiang fault shows 50 million years of Earth's history torn asunder