A University of British Columbia researcher has helped create a gel – based on the mussel's knack for clinging to rocks, piers and boat hulls – that can be painted onto the walls of blood vessels and stay put, forming a protective barrier with potentially life-saving implications.
Co-invented by Assistant Professor Christian Kastrup while a postdoctoral student at the Massachusetts Institute of Technology, the gel is similar to the amino acid that enables mussels to resist the power of churning water. The variant that Kastrup and his collaborators created, described in the current issue of the online journal PNAS Early Edition, can withstand the flow of blood through arteries and veins.
The gel's "sheer strength" could shore up weakened vessel walls at risk of rupturing – much like the way putty can fill in dents in a wall, says Kastrup, a member of the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories.
By forming a stable barrier between blood and the vessel walls, the gel could also prevent the inflammation that typically occurs when a stent is inserted to widen a narrowed artery or vein; that inflammation often counteracts the opening of the vessel that the stent was intended to achieve.
The widest potential application would be preventing the rupture of blood vessel plaque. When a plaque ruptures, the resulting clot can block blood flow to the heart (triggering a heart attack) or the brain (triggering a stroke). Mice treated with a combination of the gel and an anti-inflammatory steroid had more stable plaque than a control group of untreated mice.
"By mimicking the mussel's ability to cling to objects, we created a substance that stays in place in a very dynamic environment with high flow velocities," says Kastrup, a member of UBC's Centre for Blood Research.
University of British Columbia: http://www.ubc.ca
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Popular myth has long credited New York's soft water for the city's irresistibly crusty, chewy bagels. But the chemistry behind a superior bagel is more complicated.
A powerful earthquake in Italy killed hundreds of people—and set in motion a legal battle and scientific debate that has kept seismologists on edge
The Large Hadron Collider is smashing protons at the highest energy ever attempted - but they are only test collisions, as the LHC continues to gear up its second run.
Separate sections of one of New Zealand's biggest faults appear to have ruptured simultaneously in the past, suggesting a huge quake there is possible in the future
In a central London pub, a young bearded physicist is demonstrating how to build a model of the universe from plastic Lego bricks. Clue: you need a lot of them.
Kim Jong-un's nuclear ambitions aren't the only reason a nuke-free world is looking more like a pipe dream. All nuclear states are currently upgrading their arsenals
A new study shows many animals can make their own sunscreen, which could help humans down the line
The more scientists examine H2O, the stranger it starts to seem. Water bends all the rules – but if it didn’t, ice would sink and firefighters’ hoses would be useless
CERN’s huge particle accelerator is working its way toward full operation and a new phase of exploration. But it is not only the accelerator that has been upgraded – the particle detectors have some new tricks too
A magnitude 7.3 earthquake strikes eastern Nepal, two weeks after a devastating quake that killed more than 8,000 people.