A University of British Columbia researcher has helped create a gel – based on the mussel's knack for clinging to rocks, piers and boat hulls – that can be painted onto the walls of blood vessels and stay put, forming a protective barrier with potentially life-saving implications.
Co-invented by Assistant Professor Christian Kastrup while a postdoctoral student at the Massachusetts Institute of Technology, the gel is similar to the amino acid that enables mussels to resist the power of churning water. The variant that Kastrup and his collaborators created, described in the current issue of the online journal PNAS Early Edition, can withstand the flow of blood through arteries and veins.
The gel's "sheer strength" could shore up weakened vessel walls at risk of rupturing – much like the way putty can fill in dents in a wall, says Kastrup, a member of the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories.
By forming a stable barrier between blood and the vessel walls, the gel could also prevent the inflammation that typically occurs when a stent is inserted to widen a narrowed artery or vein; that inflammation often counteracts the opening of the vessel that the stent was intended to achieve.
The widest potential application would be preventing the rupture of blood vessel plaque. When a plaque ruptures, the resulting clot can block blood flow to the heart (triggering a heart attack) or the brain (triggering a stroke). Mice treated with a combination of the gel and an anti-inflammatory steroid had more stable plaque than a control group of untreated mice.
"By mimicking the mussel's ability to cling to objects, we created a substance that stays in place in a very dynamic environment with high flow velocities," says Kastrup, a member of UBC's Centre for Blood Research.
University of British Columbia: http://www.ubc.ca
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
A sophisticated prediction software ran tens of thousands of scenarios and picked one team to win 60 percent of the time
The Insurance Institute For Highway Safety tested more than three dozen late-model vehicles to see if new safety features are preventing deaths. Chip Reid reports on the results.
Physicist Charles Townes died Tuesday. He was a key inventor of the laser and won the Nobel Prize for his discovery in 1964. But his career didn't end there.
In order to learn how lava travels before spurting out in an eruption, researchers designed a small rolling robot that can go deep inside a volcano and send live images to the surface.
It may not sound like the most useful of scientific endeavours, but the methods used to turn a hard-boiled egg back into its liquid state could bring major benefits to areas as diverse as cheese-making and cancer research
The science behind how water releases the funk from all the yeasts and bacteria hiding in your dog's fur.
The oldest rocky planets yet are 11.2 billion years old, just a little younger than the universe - meaning the galaxy made an early start on planet building
It's usually only possible to see the spot where a laser lands rather than its path, but now an ultrafast camera has caught those photons mid-flight
A team of Indian physicists has made a mathematical model that purports to explain why ants don't have traffic jams. NPR's Joe Palca explains as part of his series, Joe's Big Idea.
On a fall morning in 2009, a team of three young physicists huddled around a computer screen in a small office overlooking Broadway in New York. They were dressed for success—even the graduate student’s shirt had buttons—and a bottle of champagne was at the ready.