An industrial revolution on a minute scale is taking place in laboratories at The University of Manchester with the development of a highly complex machine that mimics how molecules are made in nature.
The artificial molecular machine developed by Professor David Leigh FRS and his team in the School of Chemistry is the most advanced molecular machine of its type in the world. Its development has been published in the journal Science.
Professor Leigh explains: "The development of this machine which uses molecules to make molecules in a synthetic process is similar to the robotic assembly line in car plants. Such machines could ultimately lead to the process of making molecules becoming much more efficient and cost effective. This will benefit all sorts of manufacturing areas as many manmade products begin at a molecular level. For example, we're currently modifying our machine to make drugs such as penicillin."
The machine is just a few nanometres long (a few millionths of a millimetre) and can only be seen using special instruments. Its creation was inspired by natural complex molecular factories where information from DNA is used to programme the linking of molecular building blocks in the correct order. The most extraordinary of these factories is the ribosome, a massive molecular machine found in all living cells.
Professor Leigh's machine is based on the ribosome. It features a functionalized nanometre-sized ring that moves along a molecular track, picking up building blocks located on the path and connecting them together in a specific order to synthesize the desired new molecule.
First the ring is threaded onto a molecular strand using copper ions to direct the assembly process. Then a "reactive arm" is attached to the rest of the machine and it starts to operate. The ring moves up and down the strand until its path is blocked by a bulky group. The reactive arm then detaches the obstruction from the track and passes it to another site on the machine, regenerating the active site on the arm. The ring is then free to move further along the strand until its path is obstructed by the next building block. This, in turn, is removed and passed to the elongation site on the ring, thus building up a new molecular structure on the ring. Once all the building blocks are removed from the track, the ring de-threads and the synthesis is over.
Professor Leigh continues: "The next step is to start using the machine to make sophisticated molecules with more building blocks. The potential is for it to be able to make molecules that have never been seen before. They're not made in nature and can't be made synthetically because of the processes currently used. This is a very exciting possibility for the future."
University of Manchester: http://www.manchester.ac.uk
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Kip Thorne looks into the black hole he helped create and thinks, “Why, of course. That's what it would do.” This particular black hole is a simulation of unprecedented accuracy. It appears to spin at nearly the speed of light, dragging bits of the universe along with it. (That's gravity for you; relativity is superweird.) In theory it was once a star, but instead of fading or exploding, it collapsed like a failed soufflé into a tiny point of inescapable singularity. A glowing ring orbiting the spheroidal maelstrom seems to curve over the top and below the bottom simultaneously.
Apeel Sciences hopes its products, which use natural methods to fend off pests and oxidization, can markedly reduce the amount of produce wasted because of spoilage.
Francis Halzen’s amazing experiment heralds the beginning of a new era in astronomy
First direct detection of dark matter, thought to make up most of the matter in the universe, would be a historic breakthrough
Geologists, climate scientists, ecologists and a lawyer gather in Berlin for talks on whether to rename age of human lifeHumanitys terrifying impact on Earth justifies new Anthropocene epoch
This month in Italy, three judges have a chance to undo the Kafkaesque nightmare that has ensnared some of the country’s top scientists for almost five years. So far it looks doubtful they will. In 2012, seven scientists and engineers were convicted of manslaughter for things they said and did not say in the days
Turkey's eternal fires have remained burning for thousands of years but now the source of the methane that fuels them has been found
Lockheed Martin Corp said on Wednesday it had made a technological breakthrough in developing a power source based on nuclear fusion, and the first reactors, small enough to fit on the back of a truck, could be ready for use in a decade.
But the hotspot predates the use of hydraulic fracking in the region, putting renewed attention on how older forms of natural gas production contribute to global climate change
A complicated technique used on LHC data for the first time has revealed two new particles, one of which has a combination of properties never seen before