Researchers identify genetic root to early-onset prostate cancer Prostate cancer is often considered an elderly man's disease, and little is known about the approximately 2% of cases that arise in men who are aged 50 years or younger. Research published in the February 11th issue of the Cell Press journal Cancer Cell uncovers the genetic origin of such early-onset prostate cancer. The findings could help in the development of new diagnostic, prognostic,
Genetics Source: Cell Press
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Tuesday, Feb 12, 2013, 12:45pm Rating: | Views: 1239 | Comments: 0
Protein paves the way for correct stem cell differentiation A single embryonic stem cell can develop into more than 200 specialized cell types that make up our body. This maturation process is called differentiation and is tightly regulated. If the regulation is lost, specialized cells cannot develop correctly during development. In adulthood, the specialized cells may forget their identity and develop into cancer cells. Research from BRIC, University of C
Molecular Biology Source: University of Copenhagen
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Friday, Feb 08, 2013, 4:00pm Rating: | Views: 1358 | Comments: 0
Dickkopf makes fountain of youth in the brain run dry Cognitive decline in old age is linked to decreasing production of new neurons. Scientists from the German Cancer Research Center have discovered in mice that significantly more neurons are generated in the brains of older animals if a signaling molecule called Dickkopf-1 is turned off. In tests for spatial orientation and memory, mice in advanced adult age whose Dickkopf gene had been silenced re
Neuroscience Source: Helmholtz Association of German Research Centres
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Friday, Feb 08, 2013, 2:00pm Rating: | Views: 1485 | Comments: 0
Genetics Source: Duke University Medical Center
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Wednesday, Feb 06, 2013, 4:15pm Rating: | Views: 2476 | Comments: 0
Engineered oncolytic herpes virus inhibits ovarian and breast cancer metastases A genetically reprogrammed Herpes simplex virus (HSV) can cure metastatic diffusion of human cancer cells in the abdomen of laboratory mice, according to a new study published January 31 in the Open Access journal PLOS Pathogens. The paper reports on the collaborative research from scientists at the at the University of Bologna and specifically describes that the HSV converted into a therap
Molecular Biology Source: Public Library of Science
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Friday, Feb 01, 2013, 4:30pm Rating: | Views: 1638 | Comments: 0
Understanding 'master regulator' genes could lead to better cancer treatments Cell division is serious business. Cells that divide incorrectly can lead to birth defects or set the stage for cancer. A new discovery from the Oklahoma Medical Research Foundation has identified how two genes work together to make sure chromosomes are distributed properly when cells divide, providing new insights that could contribute to the future development of cancer treatments.
Genetics Source: Oklahoma Medical Research Foundation
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Friday, Feb 01, 2013, 2:30pm Rating: | Views: 1221 | Comments: 0
1 of the key circuits in regulating genes involved in producing blood stem cells is deciphered Researchers from the group on stem cells and cancer at IMIM (Hospital del Mar Medical Research Institute) have deciphered one of the gene regulation circuits which would make it possible to generate hematopoietic blood cells, i.e. blood tissue stem cells. This finding is essential to generate these cells in a laboratory in the future, a therapy that could benefit patients with leukaemia or other d
Molecular Biology Source: IMIM (Hospital del Mar Medical Research Institute)
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Friday, Feb 01, 2013, 11:45am Rating: | Views: 1276 | Comments: 0
Some health benefits of berries may not make it past your mouth Research has suggested that compounds that give colorful fruits their rich hues, especially berries, promote health and might even prevent cancer. But for the first time, scientists have exposed extracts from numerous berries high in those pigments to human saliva to see just what kinds of health-promoting substances are likely to survive and be produced in the mouth.
Health Source: Ohio State University
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Tuesday, Jan 29, 2013, 12:00pm Rating: | Views: 1131 | Comments: 0
Cancer Source: Duke University Medical Center
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Tuesday, Jan 29, 2013, 8:00am Rating: | Views: 1090 | Comments: 0
HIV-like viruses in non-human primates have existed much longer than previously thought Viruses similar to those that cause AIDS in humans were present in non-human primates in Africa at least 5 million years ago and perhaps up to 12 million years ago, according to study published January 24 in the Open Access journal PLOS Pathogens by scientists at Fred Hutchinson Cancer Research Center. Until now, researchers have hypothesized that such viruses originated much more recently.
Genetics Source: Public Library of Science
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Friday, Jan 25, 2013, 5:15pm Rating: | Views: 1394 | Comments: 0
Gene sequencing project mines data once considered 'junk' for clues about cancer Genome sequencing data once regarded as junk is now being used to gain important clues to help understand disease. The latest example comes from the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project, where scientists have developed an approach to mine the repetitive segments of DNA at the ends of chromosomes for insigh
Genetics Source: St. Jude Children's Research Hospital
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Friday, Jan 25, 2013, 1:15pm Rating: | Views: 1128 | Comments: 0
Scientists find cancer-causing virus in the brain, potential connection to epilepsy Researchers at Shriner's Hospital Pediatric Research Center at the Temple University School of Medicine, and the University of Pennsylvania have evidence linking the human papillomavirus 16 (HPV16) – the most common cause of cervical cancer – to a common form of childhood epilepsy. They have shown for the first time that HPV16 may be present in the human brain, and found that
Genetics Source: Temple University Health System
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Friday, Jan 25, 2013, 11:30am Rating: | Views: 1198 | Comments: 0
Vitamin D holds promise in battling a deadly breast cancer In research published in the Jan. 21 issue of The Journal of Cell Biology, a team led by Susana Gonzalo, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, has discovered a molecular pathway that contributes to triple-negative breast cancer, an often deadly and treatment resistant form of cancer that tends to strike younger women. In add
Cancer Source: Saint Louis University
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Thursday, Jan 24, 2013, 8:15am Rating: | Views: 1367 | Comments: 0
New model may help predict response to chemotherapy for colorectal cancer Scientists may be able to better predict which patients with colorectal cancer will respond to chemotherapy using a new mathematical model that measures the amount of stress required for a cancer cell to die without harming healthy tissue. The results of this study are published in Cancer Research, a journal of the American Association for Cancer Research.
Cancer Source: American Association for Cancer Research
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Friday, Jan 18, 2013, 8:00am Rating: | Views: 1248 | Comments: 0
Scientists uncover potential drug target to block cell death in Parkinson's disease Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, Amyotrophic Lateral Sclerosis and Parkinson's disease. Now, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that blocking the interaction of a critical enzyme may counteract the destruction of neurons ass
Neuroscience Source: Scripps Research Institute
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Friday, Jan 11, 2013, 1:15pm Rating: | Views: 1193 | Comments: 0
Sickle cells show potential to attack aggressive cancer tumors By harnessing the very qualities that make sickle cell disease a lethal blood disorder, a research team led by Duke Medicine and Jenomic, a private cancer research company in Carmel, Calif., has developed a way to deploy the misshapen red blood cells to fight cancer tumors.
Cancer Source: Duke University Medical Center
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Thursday, Jan 10, 2013, 2:45pm Rating: | Views: 1388 | Comments: 0
Cancer Source: Oregon State University
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Wednesday, Jan 09, 2013, 11:15am Rating: | Views: 1135 | Comments: 0
Cancer-specific killer T cells from induced pluripotent stem cells Researchers from the RIKEN Research Centre for Allergy and Immunology in Japan report today that they have succeeded for the first time in creating cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS cells). To create these killer cells, the team first had to reprogram T lymphocytes specialized in killing a certain type of cancer, into iPS cel
Stem cells Source: RIKEN
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Friday, Jan 04, 2013, 10:30am Rating: | Views: 1386 | Comments: 0
Research uncovers new insight into cell development and cancer Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on
Molecular Biology Source: University of North Carolina Health Care
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Wednesday, Jan 02, 2013, 5:00pm Rating: | Views: 1211 | Comments: 0
Cancer Source: Stanford University Medical Center
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Wednesday, Jan 02, 2013, 4:15pm Rating: | Views: 1397 | Comments: 0
Preventing prostate cancer through androgen deprivation may have harmful effects The use of androgen deprivation therapies to prevent precancerous prostate abnormalities developing into aggressive prostate cancer may have adverse effects in men with precancers with specific genetic alterations, according to data from a preclinical study recently published in Cancer Discovery, a journal of the American Association for Cancer Research.
Cancer Source: American Association for Cancer Research
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Friday, Dec 21, 2012, 10:15am Rating: | Views: 1677 | Comments: 0
Immune therapy successfully treats brain tumors in mice Using an artificial protein that stimulates the body's natural immune system to fight cancer, a research team at Duke Medicine has engineered a lethal weapon that kills brain tumors in mice while sparing other tissue. If it can be shown to work in humans, it would overcome a major obstacle that has hampered the effectiveness of immune-based therapies.
Cancer Source: Duke University Medical Center
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Tuesday, Dec 18, 2012, 12:45pm Rating: | Views: 1176 | Comments: 0
Study unravels biological pathway that controls the leakiness of blood vessels A research team led by scientists at Mayo Clinic in Florida have decoded the entire pathway that regulates leakiness of blood vessels — a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress.
Molecular Biology Source: Mayo Clinic
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Tuesday, Dec 18, 2012, 10:15am Rating: | Views: 1176 | Comments: 0
Older and younger chronic leukemia patients may need different therapy Doctors should use different therapies when treating older and younger patients with chronic lymphocytic leukemia, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James).
Cancer Source: Ohio State University Medical Center
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Thursday, Dec 13, 2012, 10:15am Rating: | Views: 1092 | Comments: 0
Anti-aging gene identified as tumor suppressor in mice A new study sheds more light on how an anti-aging gene suppresses cancer growth, joint University of Michigan Health System and Harvard Medical School research shows.
Genetics Source: University of Michigan Health System
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Wednesday, Dec 12, 2012, 10:45am Rating: | Views: 1106 | Comments: 0
Cancer Source: The Translational Genomics Research Institute
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Saturday, Dec 08, 2012, 8:15am Rating: | Views: 1425 | Comments: 0
Protein controlling glucose metabolism also a tumor suppressor A protein known to regulate how cells process glucose also appears to be a tumor suppressor, adding to the potential that therapies directed at cellular metabolism may help suppress tumor growth. In their report in the Dec. 7 issue of Cell, a multi-institutional research team describes finding that cells lacking the enzyme SIRT6, which controls how cells process glucose, quickly become can
Cancer Source: Massachusetts General Hospital
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Friday, Dec 07, 2012, 11:30am Rating: | Views: 1252 | Comments: 0
Genetic data shows that skin cancer risk includes more than UV exposure It's common knowledge that excessive UV exposure from sunlight raises your chances for skin cancer, but predicting whether someone will actually develop skin cancer remains difficult. In a new research report, scientists from the University of Alabama at Birmingham (UAB) and the University of Wisconsin–Madison show that the risk for skin cancer involves numerous
Genetics Source: Genetics Society of America
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Wednesday, Dec 05, 2012, 10:00am Rating: | Views: 1450 | Comments: 0
X-ray analysis deciphers master regulator important for skin cancer With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma. The results, published in the scientific journal "Genes & Development", throw new light on the workings of the so-called Microphthalmia-associated Transcription Factor MITF, that is not onl
Genetics Source: Deutsches Elektronen-Synchrotron DESY
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Monday, Dec 03, 2012, 1:00pm Rating: | Views: 1171 | Comments: 0