Taming suspect gene reverses schizophrenia-like abnormalities in mice Scientists have reversed behavioral and brain abnormalities in adult mice that resemble some features of schizophrenia by restoring normal expression to a suspect gene that is over-expressed in humans with the illness. Targeting expression of the gene Neuregulin1, which makes a protein important for brain development, may hold promise for treating at least some patients with the brain disorder, sa
Neuroscience Source: NIH/National Institute of Mental Health
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Thursday, May 23, 2013, 12:00pm Rating: | Views: 1887 | Comments: 0
Materials Science Source: Georgia Institute of Technology
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Wednesday, May 22, 2013, 8:45am Rating: | Views: 4045 | Comments: 0
X-ray tomography on a living frog embryo Classical X-ray radiographs provide information about internal, absorptive structures of organisms such as bones. Alternatively, X-rays can also image soft tissues throughout early embryonic development of vertebrates. Related to this, a new X-ray method was presented recently in a Nature article published by a German-American-Russian research team led by KIT.
Physiology Source: Helmholtz Association of German Research Centres
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Friday, May 17, 2013, 2:30pm Rating: | Views: 1904 | Comments: 0
Stem-cell-based strategy boosts immune system in mice Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory. The researchers showed that, in mice, the tissue can be used to foster the development of white blood cells the body needs to mount healthy immune responses and to prevent harmful autoimmune reactions.
Immunology Source: University of California - San Francisco
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Friday, May 17, 2013, 11:30am Rating: | Views: 1641 | Comments: 0
Promising treatment for progeria within reach "This study is a breakthrough for our research group after years of work. When we reduce the production of the enzyme in mice, the development of all the clinical symptoms of progeria is reduced or blocked. We have also studied cultured cells from children with progeria, and can see that when the enzyme is inhibited, the growth of the cells increases by the same mechanism as in mouse cells," says
Molecular Biology Source: University of Gothenburg
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Friday, May 17, 2013, 10:45am Rating: | Views: 2176 | Comments: 0
The developmental genetics of space and time Albert Erives, associate professor in the University of Iowa Department of Biology, and his graduate student, Justin Crocker, currently a postdoctoral researcher at the Howard Hughes Medical Institute (HHMI) Janelia Farm Research Campus, have conducted a study that reveals important and useful insights into how and why developmental genes often take inputs from two independent "morphogen concentra
Development Source: University of Iowa
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Friday, May 17, 2013, 10:15am Rating: | Views: 1797 | Comments: 0
Alligator stem cell study gives clues to tooth regeneration Alligators may help scientists learn how to stimulate tooth regeneration in people, according to new research led by the Keck School of Medicine of the University of Southern California (USC).
Development Source: University of Southern California - Health Sciences
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Tuesday, May 14, 2013, 1:30pm Rating: | Views: 3007 | Comments: 0
Prehistoric ear bones could lead to evolutionary answers The tiniest bones in the human body – the bones of the middle ear – could provide huge clues about our evolution and the development of modern-day humans, according to a study by a team of researchers that include a Texas A&M University anthropologist.
Evolution Source: Texas A&M University
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Tuesday, May 14, 2013, 11:30am Rating: | Views: 2190 | Comments: 0
Gene associated with adolescent idiopathic scoliosis identified Researchers from the RIKEN Center for Integrative Medical Sciences in Japan have identified the first gene to be associated with adolescent idiopathic scoliosis (also called AIS) across Asian and Caucasian populations. The gene is involved in the growth and development of the spine during childhood.
Genetics Source: RIKEN
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Monday, May 13, 2013, 2:30pm Rating: | Views: 2067 | Comments: 0
Mapping the embryonic epigenome A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human development. Led by Bing Ren of the Ludwig Institute for Cancer Research, Joseph Ecker of The Salk Institute for Biological St
Genetics Source: Ludwig Institute for Cancer Research
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Monday, May 13, 2013, 10:30am Rating: | Views: 1603 | Comments: 0
Scientists find potential therapeutic target for Cushing's disease Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.
Molecular Biology Source: Salk Institute
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Wednesday, May 08, 2013, 12:00pm Rating: | Views: 2603 | Comments: 0
Microbiology Source: University of Gothenburg
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Wednesday, May 08, 2013, 11:15am Rating: | Views: 3365 | Comments: 0
Activity of cancer inducing genes can be controlled by the cell's skeleton Cancer is a complex disease, in which cells undergo a series of alterations, including changes in their architecture; an increase in their ability to divide, to survive and to invade new tissues or metastasis. A category of genes, called oncogenes, is critical during cancer progression, as they codify proteins whose activity favours the development of cancer. One of these molecules, Src, is implic
Molecular Biology Source: Instituto Gulbenkian de Ciencia
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Tuesday, May 07, 2013, 4:15pm Rating: | Views: 2053 | Comments: 0
Injectable nano-network controls blood sugar in diabetics for days at a time In a promising development for diabetes treatment, researchers have developed a network of nanoscale particles that can be injected into the body and release insulin when blood-sugar levels rise, maintaining normal blood sugar levels for more than a week in animal-based laboratory tests. The work was done by researchers at North Carolina State University, the University of North Carolina at Chapel
Health Source: North Carolina State University
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Monday, May 06, 2013, 10:30am Rating: | Views: 1666 | Comments: 0
Turning human stem cells into brain cells sheds light on neural development Medical researchers have manipulated human stem cells into producing types of brain cells known to play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia and autism. The new model cell system allows neuroscientists to investigate normal brain development, as well as to identify specific disruptions in biological signals that may contribute to neuropsychiatric diseases
Neuroscience Source: Children's Hospital of Philadelphia
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Friday, May 03, 2013, 12:45pm Rating: | Views: 1616 | Comments: 0
One bad gene: Mutation that causes rare sleep disorder linked to migraines A gene mutation associated with a rare sleep disorder surprisingly also contributes to debilitating migraines, a new discovery that could change the treatment of migraines by allowing development of drugs specifically designed to treat the chronic headaches.
Genetics Source: University of Utah Health Sciences
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Friday, May 03, 2013, 10:00am Rating: | Views: 1825 | Comments: 0
Finding Nematostella: An ancient sea creature There's a new actor on the embryology stage: the starlet sea anemone Nematostella vectensis. Its career is being launched in part by Stowers Institute for Medical Research Associate Investigator Matt Gibson, Ph.D., who is giving it equal billing with what has been his laboratory's leading player, the fruit fly Drosophila melanogaster.
Development Source: Stowers Institute for Medical Research
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Friday, May 03, 2013, 8:30am Rating: | Views: 1287 | Comments: 0
Baby knows best: Fetuses emit hormone crucial to preventing preeclampsia In a study using mice, researchers from the University of North Carolina at Chapel Hill found that a hormone, adrenomedullin, plays a crucial role in preventing the pregnancy complication preeclampsia. Surprisingly, this hormone protects women from preeclampsia when emitted by the fetus, not the mother, during the most critical times in pregnancy.
Development Source: University of North Carolina Health Care
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Thursday, May 02, 2013, 1:15pm Rating: | Views: 1410 | Comments: 0
Growing new arteries, bypassing blocked ones Scientific collaborators from Yale School of Medicine and University College London (UCL) have uncovered the molecular pathway by which new arteries may form after heart attacks, strokes and other acute illnesses bypassing arteries that are blocked. Their study appears in the April 29 issue of Developmental Cell.
Development Source: Yale University
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Tuesday, Apr 30, 2013, 11:30am Rating: | Views: 1315 | Comments: 0
Adults lack stem cells for making new eggs Mammalian females ovulate periodically over their reproductive lifetimes, placing significant demands on their ovaries for egg production. Whether mammals generate new eggs in adulthood using stem cells has been a source of scientific controversy. If true, these "germ-line stem cells" might allow novel treatments for infertility and other diseases. However, new research from Carneg
Development Source: Carnegie Institution
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Tuesday, Apr 30, 2013, 10:45am Rating: | Views: 1206 | Comments: 0
Researchers identify key cellular organelle involved in gene silencing RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes — from development to physiology to stress response.
Molecular Biology Source: University of California - Riverside
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Friday, Apr 26, 2013, 1:30pm Rating: | Views: 2059 | Comments: 0
Inhibiting enzymes in the cell may lead to development and proliferation of cancer cells Blocking certain enzymes in the cell may prevent cancer cell division and growth, according to new findings from researchers at the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. The discovery is published in the April 25, 2013 issue of the journal Molecular Cell.
Cancer Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
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Friday, Apr 26, 2013, 12:15pm Rating: | Views: 1530 | Comments: 0
Periodic bursts of genetic mutations drive prostate cancer Cancer is typically thought to develop after genes gradually mutate over time, finally overwhelming the ability of a cell to control growth. But a new closer look at genomes in prostate cancer by an international team of researchers reveals that, in fact, genetic mutations occur in abrupt, periodic bursts, causing complex, large scale reshuffling of DNA driving the development of prostate cancer.
Cancer Source: Weill Cornell Medical College
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Friday, Apr 26, 2013, 12:00pm Rating: | Views: 1555 | Comments: 0
Important fertility mechanism discovered Scientists in Mainz and Aachen have discovered a new mechanism that controls egg cell fertility and that might have future therapeutic potential. It was revealed by Professor Dr. Walter Stöcker of the Institute of Zoology at Johannes Gutenberg University Mainz (JGU) that the blood protein fetuin-B plays an important and previously unknown role in the fertilization of oocytes. Fetuin-B, first ident
Development Source: Johannes Gutenberg Universitaet Mainz
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Thursday, Apr 25, 2013, 12:15pm Rating: | Views: 1707 | Comments: 0
Use of anti-epileptic drug during pregnancy associated with increased risk of autism Maternal use of valproate (a drug used for the treatment of epilepsy and other neuropsychological disorders) during pregnancy was associated with a significantly increased risk of autism in offspring, according to a study in the April 24 issue of JAMA. The authors caution that these findings must be balanced against the treatment benefits for women who require valproate for epilepsy control
Development Source: The JAMA Network Journals
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Wednesday, Apr 24, 2013, 10:45am Rating: | Views: 1199 | Comments: 0
Metastasis stem cells in the blood of breast cancer patients discovered Individual cancer cells that break away from the original tumor and circulate through the blood stream are considered responsible for the development of metastases. These dreaded secondary tumors are the main cause of cancer-related deaths. Circulating tumor cells (CTCs) detectable in a patient's blood are associated with a poorer prognosis. However, up until now, experimental evidence was lacking
Cancer Source: Helmholtz Association of German Research Centres
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Tuesday, Apr 23, 2013, 12:45pm Rating: | Views: 1796 | Comments: 0
Ecology Source: University of California - Santa Cruz
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Thursday, Apr 18, 2013, 2:15pm Rating: | Views: 2137 | Comments: 0
Scientists reveal natural process that blocks viruses The human body has the ability to ward off viruses by activating a naturally occurring protein at the cellular level, setting off a chain reaction that disrupts the levels of cholesterol required in cell membranes to enable viruses to enter cells. The findings, discovered by researchers in molecular microbiology and immunology at the Keck School of Medicine of USC, hold promise for the development
Immunology Source: University of Southern California - Health Sciences
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Thursday, Apr 18, 2013, 12:00pm Rating: | Views: 1856 | Comments: 0
Molecule treats leukemia by preventing cancer cell repair Researchers at The Jackson Laboratory have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could significantly reduce side effects and the development of treatment resistance compared with traditional chemotherapy.
Cancer Source: Jackson Laboratory
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Wednesday, Apr 17, 2013, 2:45pm Rating: | Views: 1433 | Comments: 0
Cell-permeable peptide shows promise for controlling cardiovascular disease Atherosclerosis – sometimes called "hardening of the arteries" – is a leading cause of death and morbidity in Western countries. A cell-permeable peptide containing the NF-ĸB nuclear localization sequence (NLS) shows promise as a potential agent in controlling the development of atherosclerotic disease. This study is published in the May 2013 issue of The
Health Source: Elsevier Health Sciences
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Wednesday, Apr 17, 2013, 2:30pm Rating: | Views: 3021 | Comments: 0