banner
News Archive Search
Researchers utilize genetically corrected stem cells to spark muscle regeneration
Researchers at the University of Minnesota's Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD).
Stem cells
Source: University of Minnesota Academic Health Center
Posted on: Wednesday, Mar 06, 2013, 12:45pm
Rating: | Views: 1395 | Comments: 0
Sweet news for stem cell
Scientists have used sugar-coated scaffolding to move a step closer to the routine use of stem cells in the clinic and unlock their huge potential to cure diseases from Alzheimer's to diabetes.
Stem cells
Source: University of Manchester
Posted on: Wednesday, Feb 27, 2013, 8:15am
Rating: | Views: 1244 | Comments: 0
Study reveals stem cells in a human parasite
From the point of view of its ultimate (human) host, the parasitic flatworm Schistosoma mansoni has a gruesome way of life. It hatches in feces-tainted water, grows into a larva in the body of a snail and then burrows through human skin to take up residence in the veins. Once there, it grows into an adult, mates and, if it's female, starts laying eggs. It can remain in the
Stem cells
Source: University of Illinois at Urbana-Champaign
Posted on: Tuesday, Feb 26, 2013, 1:00pm
Rating: | Views: 1314 | Comments: 0
Scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
For decades scientists around the world have attempted to regenerate primary liver cells known as hepatocytes because of their numerous biomedical applications, including hepatitis research, drug metabolism and toxicity studies, as well as transplantation for cirrhosis and other chronic liver conditions. But no lab in the world has been successful in identifying and growing liver
Stem cells
Source: Oregon Health & Science University
Posted on: Tuesday, Feb 26, 2013, 10:30am
Rating: | Views: 1327 | Comments: 0
Distinct niches in bone marrow nurture blood stem cells
In research that could one day improve the success of stem cell transplants and chemotherapy, scientists have found that distinct niches exist in bone marrow to nurture different types of blood stem cells.
Development
Source: Washington University School of Medicine
Posted on: Monday, Feb 25, 2013, 2:30pm
Rating: | Views: 1289 | Comments: 0
Stem cell discovery gives insight into motor neurone disease
A discovery using stem cells from a patient with motor neurone disease could help research into treatments for the condition. The study used a patient's skin cells to create motor neurons - nerve cells that control muscle activity - and the cells that support them called astrocytes.
Neuroscience
Source: University of Edinburgh
Posted on: Tuesday, Feb 12, 2013, 5:30pm
Rating: | Views: 1323 | Comments: 0
Implants make light work of fixing broken bones
Artificial bone, created using stem cells and a new lightweight plastic, could soon be used to heal shattered limbs.
Health
Source: University of Southampton
Posted on: Monday, Feb 11, 2013, 8:30am
Rating: | Views: 1311 | Comments: 0
Protein paves the way for correct stem cell differentiation
A single embryonic stem cell can develop into more than 200 specialized cell types that make up our body. This maturation process is called differentiation and is tightly regulated. If the regulation is lost, specialized cells cannot develop correctly during development. In adulthood, the specialized cells may forget their identity and develop into cancer cells. Research from BRIC, University of C
Molecular Biology
Source: University of Copenhagen
Posted on: Friday, Feb 08, 2013, 4:00pm
Rating: | Views: 1358 | Comments: 0
Researchers uncover key to antidepressant response
Through a series of investigations in mice and humans, Johns Hopkins researchers have identified a protein that appears to be the target of both antidepressant drugs and electroconvulsive therapy. Results of their experiments explain how these therapies likely work to relieve depression by stimulating stem cells in the brain to grow and mature. In addition, the researchers say, these experiments r
Neuroscience
Source: Johns Hopkins Medicine
Posted on: Friday, Feb 08, 2013, 11:30am
Rating: | Views: 1295 | Comments: 0
Learning from the linker
Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie reprogramming are still not understood. Scientists from the EMBL Hamburg and from the Max Planck Institut
Molecular Biology
Source: European Molecular Biology Laboratory
Posted on: Thursday, Feb 07, 2013, 10:45am
Rating: | Views: 1259 | Comments: 0
Fighting fat with fat: Stem cell discovery identifies potential obesity treatment
Ottawa scientists have discovered a trigger that turns muscle stem cells into brown fat, a form of good fat that could play a critical role in the fight against obesity. The findings from Dr. Michael Rudnicki's lab, based at the Ottawa Hospital Research Institute, were published today in the prestigious journal Cell Metabolism.
Health
Source: Ottawa Hospital Research Institute
Posted on: Wednesday, Feb 06, 2013, 1:30pm
Rating: | Views: 1478 | Comments: 0
Paired genes in stem cells shed new light on gene organization and regulation
Whitehead Institute researchers have determined that DNA transcription, the process that produces messenger RNA (mRNA) templates used in protein production, also runs in the opposite direction along the DNA to create corresponding long noncoding RNAs (lncRNAs). Moreover, the mRNAs and lncRNAs are transcribed coordinately as stem cells differentiate into other
Molecular Biology
Source: Whitehead Institute for Biomedical Research
Posted on: Tuesday, Feb 05, 2013, 2:15pm
Rating: | Views: 1256 | Comments: 0
Scientists identify elusive taste stem cells
Scientists at the Monell Center have identified the location and certain genetic characteristics of taste stem cells on the tongue. The findings will facilitate techniques to grow and manipulate new functional taste cells for both clinical and research purposes.
Stem cells
Source: Monell Chemical Senses Center
Posted on: Tuesday, Feb 05, 2013, 8:00am
Rating: | Views: 1216 | Comments: 0
Growth factor aids stem cell regeneration after radiation damage
Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters.
Molecular Biology
Source: Duke University Medical Center
Posted on: Monday, Feb 04, 2013, 11:45am
Rating: | Views: 1365 | Comments: 0
1 of the key circuits in regulating genes involved in producing blood stem cells is deciphered
Researchers from the group on stem cells and cancer at IMIM (Hospital del Mar Medical Research Institute) have deciphered one of the gene regulation circuits which would make it possible to generate hematopoietic blood cells, i.e. blood tissue stem cells. This finding is essential to generate these cells in a laboratory in the future, a therapy that could benefit patients with leukaemia or other d
Molecular Biology
Source: IMIM (Hospital del Mar Medical Research Institute)
Posted on: Friday, Feb 01, 2013, 11:45am
Rating: | Views: 1276 | Comments: 0
Tuberculosis may lurk in bone marrow stem cells of infected patients
Tuberculosis is a devastating disease that kills nearly 2 million people worldwide each year. Although antibiotics exist that can ameliorate the symptoms, the courses of therapy last for months and don't completely eradicate the disease, which frequently recurs years or decades after the initial treatment.
Microbiology
Source: Stanford University Medical Center
Posted on: Thursday, Jan 31, 2013, 12:30pm
Rating: | Views: 1342 | Comments: 0
Stem cells boost heart's natural repair mechanisms
Injecting specialized cardiac stem cells into a patient's heart rebuilds healthy tissue after a heart attack, but where do the new cells come from and how are they transformed into functional muscle?
Stem cells
Source: Cedars-Sinai Medical Center
Posted on: Thursday, Jan 31, 2013, 8:30am
Rating: | Views: 1237 | Comments: 0
Epigenetic control of cardiogenesis
Many different tissues and organs form from pluripotent stem cells during embryonic development. To date it had been known that these processes are controlled by transcription factors for specific tissues.
Genetics
Source: Max-Planck-Gesellschaft
Posted on: Wednesday, Jan 30, 2013, 11:00am
Rating: | Views: 1201 | Comments: 0
Patients' own skin cells are transformed into heart cells to create 'disease in a dish'
Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by
Molecular Biology
Source: Sanford-Burnham Medical Research Institute
Posted on: Monday, Jan 28, 2013, 11:45am
Rating: | Views: 1339 | Comments: 0
Study shows potential of differentiated iPS cells in cell therapy without immune rejection
A new study from Boston University School of Medicine (BUSM) shows that tissues derived from induced pluripotent stem (iPS) cells in an experimental model were not rejected when transplanted back into genetically identical recipients. The study, published online in Cell Stem Cell, demonstrates the potential of utilizing iPS cells to develop cell types that could offer treatment f
Stem cells
Source: Boston University Medical Center
Posted on: Monday, Jan 28, 2013, 11:15am
Rating: | Views: 1299 | Comments: 0
Retrovirus in the human genome is active in pluripotent stem cells
A retrovirus called HERV-H, which inserted itself into the human genome millions of years ago, may play an important role in pluripotent stem cells, according to a new study published in the journal Retrovirology by scientists at UMass Medical School. Pluripotent stem cells are capable of generating all tissue types, including blood cells, brain cells and heart cells. The di
Evolution
Source: University of Massachusetts Medical School
Posted on: Thursday, Jan 24, 2013, 2:00pm
Rating: | Views: 1284 | Comments: 0
Drug targets hard-to-reach leukemia stem cells responsible for relapses
Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive – and thus vulnerable – to a novel cancer stem cell-targeting drug currently under development.
Cancer
Source: University of California - San Diego
Posted on: Friday, Jan 18, 2013, 12:00pm
Rating: | Views: 1574 | Comments: 0
New insights into how leprosy infection spreads could pave the way for early intervention
Leprosy is a bacterial disease that spreads to muscles and other tissues in the body, causing neurodegeneration and muscle weakness. A new study, published by Cell Press January 17th in the journal Cell, reveals that the bacteria responsible for leprosy spread infection by hijacking specialized cells in the adult nervous system, reprogramming them into a stem cell-like state, and converting
Molecular Biology
Source: Cell Press
Posted on: Friday, Jan 18, 2013, 11:15am
Rating: | Views: 1700 | Comments: 0
Lack of protein Sp2 disrupts neuron creation in brain
A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to "program" stem cells for regeneration, which has implications for neural therapies.
Development
Source: North Carolina State University
Posted on: Wednesday, Jan 16, 2013, 8:45am
Rating: | Views: 1206 | Comments: 0
Stem-cell approach shows promise for Duchenne muscular dystrophy
Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD.
Molecular Biology
Source: University of Illinois at Urbana-Champaign
Posted on: Tuesday, Jan 15, 2013, 11:30am
Rating: | Views: 1284 | Comments: 0
Study shows that human hearts generate new cells after birth
Researchers at Boston Children's Hospital have found, for the first time that young humans (infants, children and adolescents) are capable of generating new heart muscle cells. These findings refute the long-held belief that the human heart grows after birth exclusively by enlargement of existing cells, and raise the possibility that scientists could stimulate production of new cel
Stem cells
Source: Boston Children's Hospital
Posted on: Friday, Jan 11, 2013, 8:00am
Rating: | Views: 1214 | Comments: 0
Cancer-specific killer T cells from induced pluripotent stem cells
Researchers from the RIKEN Research Centre for Allergy and Immunology in Japan report today that they have succeeded for the first time in creating cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS cells). To create these killer cells, the team first had to reprogram T lymphocytes specialized in killing a certain type of cancer, into iPS cel
Stem cells
Source: RIKEN
Posted on: Friday, Jan 04, 2013, 10:30am
Rating: | Views: 1386 | Comments: 0
Study hints that stem cells prepare for maturity much earlier than anticipated
Unlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility "pluripotency," meaning that as an organism develops, stem cells must be ready at a moment's notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells.
Development
Source: Stowers Institute for Medical Research
Posted on: Wednesday, Jan 02, 2013, 5:15pm
Rating: | Views: 1245 | Comments: 0
Research uncovers new insight into cell development and cancer
Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on
Molecular Biology
Source: University of North Carolina Health Care
Posted on: Wednesday, Jan 02, 2013, 5:00pm
Rating: | Views: 1211 | Comments: 0
Transplanted neural stem cells treat ALS in mouse model
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is untreatable and fatal. Nerve cells in the spinal cord die, eventually taking away a person's ability to move or even breathe. A consortium of ALS researchers at multiple institutions, including Sanford-Burnham Medical Research Institute, Brigham and Women's Hospital, and the University
Neuroscience
Source: Sanford-Burnham Medical Research Institute
Posted on: Thursday, Dec 20, 2012, 2:45pm
Rating: | Views: 1495 | Comments: 0
Friends