Learning from the linker Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie reprogramming are still not understood. Scientists from the EMBL Hamburg and from the Max Planck Institut
Molecular Biology Source: European Molecular Biology Laboratory
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Thursday, Feb 07, 2013, 10:45am Rating: | Views: 1259 | Comments: 0
A little tag with a large effect Nearly every cell in the human body carries a copy of the full human genome. So how is it that the cells that detect light in the human eye are so different from those of, say, the beating heart or the spleen?
Molecular Biology Source: Ludwig Institute for Cancer Research
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Tuesday, Feb 05, 2013, 12:00pm Rating: | Views: 1135 | Comments: 0
Video: The impressive aerial maneuvers of the pea aphid You might not think much about pea aphids, but it turns out they've got skills enough to get aerospace engineers excited. A report in the February 4th issue of Current Biology, a Cell Press publication, shows that the insects can free fall from the plants they feed on and—within a fraction of a second—land on their feet every time. Oftentimes, the falling aphids manage to cling to a lower p
Animal Behavior Source: Cell Press
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Tuesday, Feb 05, 2013, 11:15am Rating: | Views: 1583 | Comments: 0
Growth factor aids stem cell regeneration after radiation damage Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters.
Molecular Biology Source: Duke University Medical Center
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Monday, Feb 04, 2013, 11:45am Rating: | Views: 1365 | Comments: 0
Changes to DNA on-off switches affect cells' ability to repair breaks, respond to chemotherapy Double-strand breaks in DNA happen every time a cell divides and replicates. Depending on the type of cell, that can be pretty often. Many proteins are involved in everyday DNA repair, but if they are mutated, the repair system breaks down and cancer can occur. Cells have two complicated ways to repair these breaks, which can affect the stability of the entire genome.
Molecular Biology Source: University of Pennsylvania School of Medicine
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Monday, Feb 04, 2013, 11:30am Rating: | Views: 1242 | Comments: 0
Video: Researchers capture key moments in cell death Scientists at the Walter and Eliza Hall Institute have for the first time visualised the molecular changes in a critical cell death protein that force cells to die.
Molecular Biology Source: Walter and Eliza Hall Institute
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Monday, Feb 04, 2013, 11:00am Rating: | Views: 1488 | Comments: 0
Video: This is what a fish thought looks like For the first time, researchers have been able to see a thought "swim" through the brain of a living fish. The new technology is a useful tool for studies of perception. It might even find use in psychiatric drug discovery, according to authors of the study, appearing online on January 31 in Current Biology, a Cell Press publication.
Neuroscience Source: Cell Press
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Friday, Feb 01, 2013, 1:15pm Rating: | Views: 1755 | Comments: 0
Hit by 2 hammers Mutations in single genes can cause catastrophic diseases, such as Huntington's Disease or sickle cell anemia. However, many conditions, including cancer, diabetes and birth defects are multigenic, arising from the collective failure of the function of more than one gene.
Molecular Biology Source: Stowers Institute for Medical Research
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Friday, Feb 01, 2013, 10:00am Rating: | Views: 1241 | Comments: 0
New look at cell membrane reveals surprising organization Sight would dramatically alter a blind man's understanding of an elephant, according to the old story. Now, a look directly at a cell surface is changing our understanding of cell membrane organization.
Molecular Biology Source: University of Illinois at Urbana-Champaign
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Tuesday, Jan 29, 2013, 4:15pm Rating: | Views: 1139 | Comments: 0
Protein family linked to autism suppresses the development of inhibitory synapses Synapse development is promoted by a variety of cell adhesion molecules that connect neurons and organize synaptic proteins. Many of these adhesion molecules are linked to neurodevelopmental disorders; mutations in neuroligin and neurexin proteins, for example, are associated with autism and schizophrenia. According to a study in The Journal of Cell Biology, another family of proteins linked to th
Neuroscience Source: Rockefeller University Press
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Tuesday, Jan 29, 2013, 12:45pm Rating: | Views: 1324 | Comments: 0
Patients' own skin cells are transformed into heart cells to create 'disease in a dish' Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by
Molecular Biology Source: Sanford-Burnham Medical Research Institute
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Monday, Jan 28, 2013, 11:45am Rating: | Views: 1339 | Comments: 0
Dung beetles follow the Milky Way You might expect dung beetles to keep their "noses to the ground," but they are actually incredibly attuned to the sky. A report published online on January 24 in Current Biology, a Cell Press publication, shows that even on the darkest of nights, African ball-rolling insects are guided by the soft glow of the Milky Way.
Animal Behavior Source: Cell Press
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Friday, Jan 25, 2013, 12:00pm Rating: | Views: 2343 | Comments: 0
Molecular Biology Source: University at Buffalo
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Thursday, Jan 24, 2013, 10:30am Rating: | Views: 1184 | Comments: 0
Vitamin D holds promise in battling a deadly breast cancer In research published in the Jan. 21 issue of The Journal of Cell Biology, a team led by Susana Gonzalo, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, has discovered a molecular pathway that contributes to triple-negative breast cancer, an often deadly and treatment resistant form of cancer that tends to strike younger women. In add
Cancer Source: Saint Louis University
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Thursday, Jan 24, 2013, 8:15am Rating: | Views: 1367 | Comments: 0
A diffusion trap Over the past several years, Rong Li, Ph.D., at the Stowers Institute for Medical Research has been making crucial discoveries about the development of cell polarity—the process by which one side of a cell becomes different from the other side. Such polarity is critical for the functioning of the vast majority of cells. The outside surface of skin cells is very different from the
Molecular Biology Source: Stowers Institute for Medical Research
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Wednesday, Jan 23, 2013, 1:30pm Rating: | Views: 1170 | Comments: 0
Enzyme helps cancer cells avoid genetic instability Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in the January 21st issue of The Journal of Cell Biology.
Cancer Source: Rockefeller University Press
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Tuesday, Jan 22, 2013, 1:15pm Rating: | Views: 1237 | Comments: 0
Molecular forces are key to proper cell division Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.
Marine Biology Source: University of Massachusetts at Amherst
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Tuesday, Jan 22, 2013, 1:00pm Rating: | Views: 1345 | Comments: 0
Developing microbial cell factories by employing synthetic small regulatory RNAs Biotechnologists have been working hard to address the climate change and limited fossil resource issues through the development of sustainable processes for the production of chemicals, fuels and materials from renewable non-food biomass. One promising sustainable technology is the use of microbial cell factories for the efficient production of desired chemicals and materials. When microorganisms
Molecular Biology Source: The Korea Advanced Institute of Science and Technology (KAIST)
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Tuesday, Jan 22, 2013, 12:30pm Rating: | Views: 1170 | Comments: 0
Molecular Biology Source: University of North Carolina Health Care
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Friday, Jan 18, 2013, 4:00pm Rating: | Views: 1214 | Comments: 0
Researchers discover how the flu virus tells time Scientists have discovered that that the flu virus can essentially tell time, thereby giving scientists the ability to reset the virus' clock and combat it in more effective ways. According to researchers at the Icahn School of Medicine at Mount Sinai, the flu knows how much time it has to multiply, infect other cells, and spread to another human being. If it leaves a cell too soon, the virus is t
Molecular Biology Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
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Friday, Jan 18, 2013, 12:15pm Rating: | Views: 1143 | Comments: 0
New insights into how leprosy infection spreads could pave the way for early intervention Leprosy is a bacterial disease that spreads to muscles and other tissues in the body, causing neurodegeneration and muscle weakness. A new study, published by Cell Press January 17th in the journal Cell, reveals that the bacteria responsible for leprosy spread infection by hijacking specialized cells in the adult nervous system, reprogramming them into a stem cell-like state, and converting
Molecular Biology Source: Cell Press
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Friday, Jan 18, 2013, 11:15am Rating: | Views: 1700 | Comments: 0
Trapping malaria parasites inside host cell basis for new drugs One of the most insidious ways that parasitic diseases such as malaria and toxoplasmosis wreak their havoc is by hijacking their host's natural cellular processes, turning self against self. Researchers from the Perelman School of Medicine, University of Pennsylvania and Johns Hopkins University, led by Doron Greenbaum, Ph.D., assistant professor of Pharmacology at Penn, have ident
Molecular Biology Source: University of Pennsylvania School of Medicine
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Thursday, Jan 17, 2013, 12:00pm Rating: | Views: 1170 | Comments: 0
Stem-cell approach shows promise for Duchenne muscular dystrophy Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD.
Molecular Biology Source: University of Illinois at Urbana-Champaign
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Tuesday, Jan 15, 2013, 11:30am Rating: | Views: 1284 | Comments: 0
Study provides new clues for designing an effective HIV vaccine New insights into how a promising HIV vaccine works are provided in a study published by Cell Press January 10th in the journal Immunity. By analyzing the structure of antibody-virus complexes produced in vaccine recipients, the researchers have revealed how the vaccine triggers immune responses that could fight HIV-1 infection. The study could help guide efforts to increase the vaccine's p
Molecular Biology Source: Cell Press
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Friday, Jan 11, 2013, 11:00am Rating: | Views: 1127 | Comments: 0
Molecular Biology Source: Scripps Research Institute
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Monday, Jan 07, 2013, 12:45pm Rating: | Views: 1191 | Comments: 0
Big brains are pricey, guppy study shows Bigger brains can make animals, well, brainier, but that boost in brain size and ability comes at a price. That's according to new evidence reported on January 3rd in Current Biology, a Cell Press publication, in which researchers artificially selected guppies for large and small brain sizes.
Evolution Source: Cell Press
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Friday, Jan 04, 2013, 10:15am Rating: | Views: 1316 | Comments: 0
Research uncovers new insight into cell development and cancer Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on
Molecular Biology Source: University of North Carolina Health Care
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Wednesday, Jan 02, 2013, 5:00pm Rating: | Views: 1211 | Comments: 0
Protein kinase Akt identified as arbiter of cancer stem cell fate The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author Honglin Zhou, MD, PhD and Weihua Li, co-first author, both from the Center for Resuscitation Sciences, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, and
Molecular Biology Source: University of Pennsylvania School of Medicine
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Friday, Dec 21, 2012, 2:00pm Rating: | Views: 1622 | Comments: 0
Chromosome 'anchors' organize DNA during cell division For humans to grow and to replace and heal damaged tissues, the body's cells must continually reproduce, a process known as "cell division," by which one cell becomes two, two become four, and so on. A key question of biomedical research is how chromosomes, which are duplicated during cell division so that each daughter cell receives an exact copy of a person's genome, are arranged
Molecular Biology Source: Salk Institute
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Friday, Dec 21, 2012, 1:30pm Rating: | Views: 1272 | Comments: 0
Cellular patterns of development For a tiny embryo to grow into an entire fruit fly, mouse or human, the correct genes in each cell must turn on and off in precisely the right sequence. This intricate molecular dance produces the many parts of the whole creature, from muscles and skin to nerves and blood.
Molecular Biology Source: Stowers Institute for Medical Research
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Friday, Dec 21, 2012, 12:15pm Rating: | Views: 1151 | Comments: 0