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Cancer Drugs Should Cost Less, Say Doctors
Doctors argue that some drug companies are charging too much for their cancer drugs, to the detriment of patients.A group of more than 100 cancer experts have called out drug companies for the high prices of cancer drugs. The doctors, all specialists in chronic myelogenous leukemia or CML,  published their opinion on what they call “astronomical” prices on Friday in the scientific journal Blood.
Cancer
Source: Technology Review
Posted on: Tuesday, Apr 30, 2013, 10:18am
Rating: | Views: 1102 | Comments: 0
How does pregnancy reduce breast cancer risk?
Being pregnant while young is known to protect a women against breast cancer. But why? Research in BioMed Central's open access journal Breast Cancer Research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.
Cancer
Source: BioMed Central
Posted on: Monday, Apr 29, 2013, 11:30am
Rating: | Views: 1413 | Comments: 0
Physicists, biologists unite to expose how cancer spreads
Cancer cells that can break out of a tumor and invade other organs are more aggressive and nimble than nonmalignant cells, according to a new multi-institutional nationwide study. These cells exert greater force on their environment and can more easily maneuver small spaces.
Cancer
Source: Princeton University
Posted on: Monday, Apr 29, 2013, 11:00am
Rating: | Views: 1684 | Comments: 0
Reviving a foe of cancer
Cancer cells are a problem for the body because they multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don't belong. One protein that keeps healthy cells from behaving this way is a tumor suppressor named p53. This protein stops potentially precancerous cells from dividing and induces suicide in those that
Cancer
Source: Ludwig Institute for Cancer Research
Posted on: Friday, Apr 26, 2013, 1:00pm
Rating: | Views: 5963 | Comments: 0
Inhibiting enzymes in the cell may lead to development and proliferation of cancer cells
Blocking certain enzymes in the cell may prevent cancer cell division and growth, according to new findings from researchers at the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. The discovery is published in the April 25, 2013 issue of the journal Molecular Cell.
Cancer
Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
Posted on: Friday, Apr 26, 2013, 12:15pm
Rating: | Views: 1530 | Comments: 0
Periodic bursts of genetic mutations drive prostate cancer
Cancer is typically thought to develop after genes gradually mutate over time, finally overwhelming the ability of a cell to control growth. But a new closer look at genomes in prostate cancer by an international team of researchers reveals that, in fact, genetic mutations occur in abrupt, periodic bursts, causing complex, large scale reshuffling of DNA driving the development of prostate cancer.
Cancer
Source: Weill Cornell Medical College
Posted on: Friday, Apr 26, 2013, 12:00pm
Rating: | Views: 1555 | Comments: 0
Link between inherited endocrine tumor syndrome and much-studied cell pathway
A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1). Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin.
Molecular Biology
Source: University of Pennsylvania School of Medicine
Posted on: Thursday, Apr 25, 2013, 1:30pm
Rating: | Views: 1519 | Comments: 0
Team deploys hundreds of tiny untethered surgical tools in first animal biopsies
By using swarms of untethered grippers, each as small as a speck of dust, Johns Hopkins engineers and physicians say they have devised a new way to perform biopsies that could provide a more effective way to access narrow conduits in the body as well as find early signs of cancer or other diseases.
Technology
Source: Johns Hopkins University
Posted on: Wednesday, Apr 24, 2013, 1:00pm
Rating: | Views: 1869 | Comments: 0
Virus kills melanoma in animal model, spares normal cells
Researchers from Yale University School of Medicine have demonstrated that vesicular stomatitis virus (VSV) is highly competent at finding, infecting, and killing human melanoma cells, both in vitro and in animal models, while having little propensity to infect non-cancerous cells.
Cancer
Source: American Society for Microbiology
Posted on: Wednesday, Apr 24, 2013, 11:15am
Rating: | Views: 1345 | Comments: 0
Skin cancer linked to future risk of other cancers
White people who have types of skin cancer other than melanoma (non-melanoma skin cancer) may be at increased risk of having other forms of cancer in the future, according to a study by US researchers published in this week's PLOS Medicine.
Cancer
Source: Public Library of Science
Posted on: Wednesday, Apr 24, 2013, 10:00am
Rating: | Views: 1404 | Comments: 0
Metastasis stem cells in the blood of breast cancer patients discovered
Individual cancer cells that break away from the original tumor and circulate through the blood stream are considered responsible for the development of metastases. These dreaded secondary tumors are the main cause of cancer-related deaths. Circulating tumor cells (CTCs) detectable in a patient's blood are associated with a poorer prognosis. However, up until now, experimental evidence was lacking
Cancer
Source: Helmholtz Association of German Research Centres
Posted on: Tuesday, Apr 23, 2013, 12:45pm
Rating: | Views: 1796 | Comments: 0
Video: Radioactive bacteria targets metastatic pancreatic cancer
Researchers at Albert Einstein College of Medicine of Yeshiva University have developed a therapy for pancreatic cancer that uses Listeria bacteria to selectively infect tumor cells and deliver radioisotopes into them. The experimental treatment dramatically decreased the number of metastases (cancers that have spread to other parts of the body) in a mouse mod
Microbiology
Source: Albert Einstein College of Medicine
Posted on: Tuesday, Apr 23, 2013, 10:45am
Rating: | Views: 2397 | Comments: 0
Hundreds of alterations and potential drug targets to starve tumors identified
A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis, conducted by researchers at Columbia University Medical Center, also identified hundreds of potential drug targets that could cut off a tumor's fuel supply or interfere with its ability to synthesize essential building blocks. The st
Cancer
Source: Columbia University Medical Center
Posted on: Monday, Apr 22, 2013, 1:30pm
Rating: | Views: 1466 | Comments: 0
Same protein that fires up cancer-promoting Erk also blocks its activation
A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology.
Molecular Biology
Source: University of Texas M. D. Anderson Cancer Center
Posted on: Monday, Apr 22, 2013, 1:15pm
Rating: | Views: 1408 | Comments: 0
Novel monoclonal antibody inhibits tumor growth in breast cancer and angiosarcoma
A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.
Cancer
Source: University of North Carolina Health Care
Posted on: Monday, Apr 22, 2013, 1:00pm
Rating: | Views: 1540 | Comments: 0
Researchers identify new potential target for cancer therapy
Researchers at UT Southwestern Medical Center have found that alternative splicing – a process that allows a single gene to code for multiple proteins – appears to be a new potential target for anti-telomerase cancer therapy.
Cancer
Source: UT Southwestern Medical Center
Posted on: Monday, Apr 22, 2013, 12:30pm
Rating: | Views: 1376 | Comments: 0
Study finds scientific basis for cognitive complaints of breast cancer patients
For many years, breast cancer patients have reported experiencing difficulties with memory, concentration and other cognitive functions following cancer treatment. Whether this mental "fogginess" is psychosomatic or reflects underlying changes in brain function has been a bone of contention among scientists and physicians.
Neuroscience
Source: University of California - Los Angeles
Posted on: Monday, Apr 22, 2013, 11:45am
Rating: | Views: 1290 | Comments: 0
New computational model can predict breast cancer survival
Columbia Engineering researchers, led by Dimitris Anastassiou, Charles Batchelor Professor in Electrical Engineering and member of the Columbia Initiative in Systems Biology, have developed a new computational model that is highly predictive of breast cancer survival. The team, who won the Sage Bionetworks / DREAM Breast Cancer Prognosis Challenge for this work, publis
Cancer
Source: Columbia University
Posted on: Thursday, Apr 18, 2013, 10:15am
Rating: | Views: 1512 | Comments: 0
Molecule treats leukemia by preventing cancer cell repair
Researchers at The Jackson Laboratory have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could significantly reduce side effects and the development of treatment resistance compared with traditional chemotherapy.
Cancer
Source: Jackson Laboratory
Posted on: Wednesday, Apr 17, 2013, 2:45pm
Rating: | Views: 1433 | Comments: 0
Transcription factors regulating blood oxygen linked to melanoma metastases
Researchers at the University of North Carolina have discovered that transcription factors regulating the levels of oxygen in the blood also play a role in the spread of the skin cancer melanoma.
Molecular Biology
Source: University of North Carolina Health Care
Posted on: Wednesday, Apr 17, 2013, 11:00am
Rating: | Views: 1496 | Comments: 0
Gene-expression signature may signify risk for recurrence, metastasis in prostate cancer
A team led by Massachusetts General Hospital (MGH) researchers has identified a genetic signature that appears to reflect the risk of tumor recurrence or spread in men surgically treated for prostate cancer. If confirmed in future studies, this finding not only may help determine which patients require additional treatment after the cancerous gland has been removed, it also may help address the m
Genetics
Source: Massachusetts General Hospital
Posted on: Tuesday, Apr 16, 2013, 2:30pm
Rating: | Views: 2020 | Comments: 0
Key bone marrow protein identified as potential new leukemia treatment target
A new study on how the progression of acute lymphocytic leukemia (ALL) is influenced by the bone marrow environment has demonstrated for the first time that targeting a specialized protein known as osteopontin (OPN) may be an effective strategy to increase the efficacy of chemotherapy in patients with this type of blood cancer. Study data were published online today
Cancer
Source: American Society of Hematology
Posted on: Tuesday, Apr 16, 2013, 12:45pm
Rating: | Views: 1477 | Comments: 0
Cancer cell metabolism kills
ATP is the main energy currency of cells and one might expect that not only contracting muscle, but also uncontrollably dividing cancer cells would have a high demand for ATP. However, for some reason cancer cells have re-programmed their metabolic engines to produce less ATP. The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cance
Molecular Biology
Source: University of Helsinki
Posted on: Tuesday, Apr 16, 2013, 11:00am
Rating: | Views: 1670 | Comments: 0
Gene sequencing project finds new mutations to blame for a majority of brain tumor subtype
The St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project has identified mutations responsible for more than half of a subtype of childhood brain tumor that takes a high toll on patients. Researchers also found evidence the tumors are susceptible to drugs already in development.
Genetics
Source: St. Jude Children's Research Hospital
Posted on: Monday, Apr 15, 2013, 1:30pm
Rating: | Views: 2661 | Comments: 0
Signature of circulating breast tumor cells that spread to the brain found
Some breast tumor circulating cells in the bloodstream are marked by a constellation of biomarkers that identify them as those destined to seed the brain with a deadly spread of cancer, said researchers led by those at Baylor College of Medicine in a report that appears online in the journal Science Translational Medicine.
Cancer
Source: Baylor College of Medicine
Posted on: Thursday, Apr 11, 2013, 10:30am
Rating: | Views: 1400 | Comments: 0
Researchers find avian virus may be harmful to cancer cells
A study at the Virginia-Maryland Regional College of Veterinary Medicine has identified a chicken-killing virus as a promising treatment for prostate cancer in humans.
Cancer
Source: Virginia Tech
Posted on: Tuesday, Apr 09, 2013, 2:00pm
Rating: | Views: 1475 | Comments: 0
Engineered T cells kill tumors but spare normal tissue in an animal model
The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal immune response against cancer. Identifying which antigens a patient's tumor cells express is the cornerstone of designing cancer therapy for that individual.
Cancer
Source: University of Pennsylvania School of Medicine
Posted on: Monday, Apr 08, 2013, 12:30pm
Rating: | Views: 1435 | Comments: 0
Shutting down DNA construction: How senescence halts growth of potential cancers
Researchers from The Wistar Institute explain a new molecular mechanism behind the phenomenon of oncogene-induced senescence. By depriving the cell of the ability to make new nucleotides—the building blocks of DNA molecules—cells can suppress cancer development by forcing a damaged cell into a senescent state, where the cell remains alive yet cannot reproduce. According to the researchers, th
Cancer
Source: The Wistar Institute
Posted on: Friday, Apr 05, 2013, 12:45pm
Rating: | Views: 3031 | Comments: 0
Study reveals that chemotherapy works in an unexpected way
It's generally thought that anticancer chemotherapies work like antibiotics do, by directly killing off what's harmful. But new research published online on April 4 in the Cell Press journal Immunity shows that effective chemotherapies actually work by mobilizing the body's own immune cells to fight cancer. Researchers found that chemo-treated dying tumors secrete a factor that attracts cer
Cancer
Source: Cell Press
Posted on: Friday, Apr 05, 2013, 11:30am
Rating: | Views: 1358 | Comments: 0
Researchers say 1 specific microrna promotes tumor growth and cancer spread
Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. As a therapeutic target, miR-155 could potentially provide a new avenue of treatment when targeted with drugs to suppress its activity.
Cancer
Source: H. Lee Moffitt Cancer Center & Research Institute
Posted on: Thursday, Apr 04, 2013, 2:00pm
Rating: | Views: 1397 | Comments: 0
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