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Novel RNA-based classification system for colorectal cancer 
A novel transcriptome-based classification of colon cancer that improves the current disease stratification based on clinicopathological variables and common DNA markers is presented in a study published in PLOS Medicine this week. (A transcriptome is all RNA produced by a population of cells.) Pr. Pierre Laurent-Puig and colleagues from INSERM in Paris, France used genetic information from
A novel transcriptome-based classification of colon cancer that improves the current disease stratification based on clinicopathological variables and common DNA markers is presented in a study published in PLOS Medicine this week. (A transcriptome is all RNA produced by a population of cells.) Pr. Pierre Laurent-Puig and colleagues from INSERM in Paris, France used genetic information from
Cancer
Source: Public Library of Science
Posted on: Wednesday, May 22, 2013, 10:15am
Rating: | Views: 1887 | Comments: 0
Source: Public Library of Science
Posted on: Wednesday, May 22, 2013, 10:15am
Rating: | Views: 1887 | Comments: 0
Older prostate cancer patients should think twice before undergoing treatment
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multicenter study led by researchers in the UCLA Department of Urology.
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multicenter study led by researchers in the UCLA Department of Urology.
Cancer
Source: University of California - Los Angeles Health Sciences
Posted on: Tuesday, May 21, 2013, 8:15am
Rating: | Views: 1683 | Comments: 0
Source: University of California - Los Angeles Health Sciences
Posted on: Tuesday, May 21, 2013, 8:15am
Rating: | Views: 1683 | Comments: 0
Team finds mechanism linking key inflammatory marker to cancer
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer
Source: University of Illinois at Urbana-Champaign
Posted on: Monday, May 20, 2013, 11:30am
Rating: | Views: 1698 | Comments: 0
Source: University of Illinois at Urbana-Champaign
Posted on: Monday, May 20, 2013, 11:30am
Rating: | Views: 1698 | Comments: 0
Genetic diversity within tumors predicts outcome in head and neck cancer
A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. In the May 20 issue of the journal Cancer, investigators at Massachusetts General Hospital (MGH) and Massachusetts Eye and Ear Infirmary describe how their measure was a better predictor of survi
A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. In the May 20 issue of the journal Cancer, investigators at Massachusetts General Hospital (MGH) and Massachusetts Eye and Ear Infirmary describe how their measure was a better predictor of survi
Cancer
Source: Massachusetts General Hospital
Posted on: Monday, May 20, 2013, 11:15am
Rating: | Views: 1590 | Comments: 0
Source: Massachusetts General Hospital
Posted on: Monday, May 20, 2013, 11:15am
Rating: | Views: 1590 | Comments: 0
Scientists uncover the fundamental property of astatine, the rarest atom on Earth
An international team of scientists, including a University of York researcher, has carried out ground-breaking experiments to investigate the atomic structure of astatine (Z=85), the rarest naturally occurring element on Earth. Astatine (At) is of significant interest as its decay properties make it an ideal short-range radiation source for targeted alpha therapy in cancer treatment. The
An international team of scientists, including a University of York researcher, has carried out ground-breaking experiments to investigate the atomic structure of astatine (Z=85), the rarest naturally occurring element on Earth. Astatine (At) is of significant interest as its decay properties make it an ideal short-range radiation source for targeted alpha therapy in cancer treatment. The
Chemistry
Source: University of York
Posted on: Wednesday, May 15, 2013, 10:00am
Rating: | Views: 3566 | Comments: 0
Source: University of York
Posted on: Wednesday, May 15, 2013, 10:00am
Rating: | Views: 3566 | Comments: 0
Researchers discover master regulator that drives majority of lymphoma
A soon-to-be-tested class of drug inhibitors were predicted to help a limited number of patients with B-cell lymphomas with mutations affecting the EZH2 protein. However, a research team, led by investigators at Weill Cornell Medical College, now report that these agents may, in fact, help a much broader cross section of lymphoma patients.
A soon-to-be-tested class of drug inhibitors were predicted to help a limited number of patients with B-cell lymphomas with mutations affecting the EZH2 protein. However, a research team, led by investigators at Weill Cornell Medical College, now report that these agents may, in fact, help a much broader cross section of lymphoma patients.
Cancer
Source: Weill Cornell Medical College
Posted on: Tuesday, May 14, 2013, 12:15pm
Rating: | Views: 1560 | Comments: 0
Source: Weill Cornell Medical College
Posted on: Tuesday, May 14, 2013, 12:15pm
Rating: | Views: 1560 | Comments: 0
Game Theory and the Treatment of Cancer
Thinking about cancer as an ecosystem is giving biologists access to a new armoury of mathematical tools for tackling it, such as evolutionary game theory
Thinking about cancer as an ecosystem is giving biologists access to a new armoury of mathematical tools for tackling it, such as evolutionary game theory
Technology
Source: Technology Review
Posted on: Tuesday, May 14, 2013, 9:00am
Rating: | Views: 1103 | Comments: 0
Source: Technology Review
Posted on: Tuesday, May 14, 2013, 9:00am
Rating: | Views: 1103 | Comments: 0
Agent Orange exposure linked to life-threatening prostate cancer
A new analysis has found a link between exposure to Agent Orange and lethal forms of prostate cancer among US Veterans. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that Agent Orange exposure history should be incorporated into prostate screening decisions for Veterans.
A new analysis has found a link between exposure to Agent Orange and lethal forms of prostate cancer among US Veterans. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that Agent Orange exposure history should be incorporated into prostate screening decisions for Veterans.
Researchers identify 4 new genetic risk factors for testicular cancer
A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The findings from this first-of-its-kind meta-analysis were reported online May 12 in Nature Genetics by researchers at the Perelman School of Medicine at the University of Pe
A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The findings from this first-of-its-kind meta-analysis were reported online May 12 in Nature Genetics by researchers at the Perelman School of Medicine at the University of Pe
Genetics
Source: University of Pennsylvania School of Medicine
Posted on: Monday, May 13, 2013, 2:45pm
Rating: | Views: 1790 | Comments: 0
Source: University of Pennsylvania School of Medicine
Posted on: Monday, May 13, 2013, 2:45pm
Rating: | Views: 1790 | Comments: 0
Study suggests link between tumor suppressors and starvation survival
A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division -- the hallmark of the disease -- it also can help make cells more fit by allowing them to fend off stress, says a University of Colorado Boulder study.
A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division -- the hallmark of the disease -- it also can help make cells more fit by allowing them to fend off stress, says a University of Colorado Boulder study.
Genetics
Source: University of Colorado at Boulder
Posted on: Monday, May 13, 2013, 1:15pm
Rating: | Views: 1937 | Comments: 0
Source: University of Colorado at Boulder
Posted on: Monday, May 13, 2013, 1:15pm
Rating: | Views: 1937 | Comments: 0
Cancer drug prevents build-up of toxic brain protein
Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects.
Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects.
Health
Source: Georgetown University Medical Center
Posted on: Monday, May 13, 2013, 12:45pm
Rating: | Views: 1639 | Comments: 0
Source: Georgetown University Medical Center
Posted on: Monday, May 13, 2013, 12:45pm
Rating: | Views: 1639 | Comments: 0
Your immune system: On surveillance in the war against cancer
Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most deadly types of breast cancer.
Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most deadly types of breast cancer.
Cancer
Source: Wake Forest Baptist Medical Center
Posted on: Monday, May 13, 2013, 11:30am
Rating: | Views: 1625 | Comments: 0
Source: Wake Forest Baptist Medical Center
Posted on: Monday, May 13, 2013, 11:30am
Rating: | Views: 1625 | Comments: 0
Mapping the embryonic epigenome
A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human development. Led by Bing Ren of the Ludwig Institute for Cancer Research, Joseph Ecker of The Salk Institute for Biological St
A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human development. Led by Bing Ren of the Ludwig Institute for Cancer Research, Joseph Ecker of The Salk Institute for Biological St
Genetics
Source: Ludwig Institute for Cancer Research
Posted on: Monday, May 13, 2013, 10:30am
Rating: | Views: 1603 | Comments: 0
Source: Ludwig Institute for Cancer Research
Posted on: Monday, May 13, 2013, 10:30am
Rating: | Views: 1603 | Comments: 0
Discovery pinpoints cause of 2 types of leukemia
Patients with two forms of leukemia, who currently have no viable treatment options, may benefit from existing drugs developed for different types of cancer, according to a study conducted by researchers at the Knight Cancer Institute at Oregon Health & Science University (OHSU).
Patients with two forms of leukemia, who currently have no viable treatment options, may benefit from existing drugs developed for different types of cancer, according to a study conducted by researchers at the Knight Cancer Institute at Oregon Health & Science University (OHSU).
Cancer
Source: Oregon Health & Science University
Posted on: Monday, May 13, 2013, 10:00am
Rating: | Views: 1606 | Comments: 0
Source: Oregon Health & Science University
Posted on: Monday, May 13, 2013, 10:00am
Rating: | Views: 1606 | Comments: 0
Researchers describe how breast cancer cells acquire drug resistance
A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death. The discovery provides new avenues to overcome drug resistance, according to researchers at Duke Cancer Institute.
A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death. The discovery provides new avenues to overcome drug resistance, according to researchers at Duke Cancer Institute.
Cancer
Source: Duke University Medical Center
Posted on: Wednesday, May 08, 2013, 1:15pm
Rating: | Views: 1590 | Comments: 0
Source: Duke University Medical Center
Posted on: Wednesday, May 08, 2013, 1:15pm
Rating: | Views: 1590 | Comments: 0
MicroRNA cooperation mutes breast cancer oncogenes
A University of Colorado Cancer Center study recently published in the journal Cell Death & Disease shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot – and without the unwanted side effects.
A University of Colorado Cancer Center study recently published in the journal Cell Death & Disease shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot – and without the unwanted side effects.
Molecular Biology
Source: University of Colorado Denver
Posted on: Wednesday, May 08, 2013, 12:15pm
Rating: | Views: 2260 | Comments: 0
Source: University of Colorado Denver
Posted on: Wednesday, May 08, 2013, 12:15pm
Rating: | Views: 2260 | Comments: 0
Genetic variations associated with susceptibility to bacteria linked to stomach disorders
Two genome-wide association studies and a subsequent meta-analysis have found that certain genetic variations are associated with susceptibility to Helicobacter pylori, a bacteria that is a major cause of gastritis and stomach ulcers and is linked to stomach cancer, findings that may help explain some of the observed variation in individual risk for H pylori infection, according to a
Two genome-wide association studies and a subsequent meta-analysis have found that certain genetic variations are associated with susceptibility to Helicobacter pylori, a bacteria that is a major cause of gastritis and stomach ulcers and is linked to stomach cancer, findings that may help explain some of the observed variation in individual risk for H pylori infection, according to a
Genetics
Source: The JAMA Network Journals
Posted on: Wednesday, May 08, 2013, 8:15am
Rating: | Views: 1968 | Comments: 0
Source: The JAMA Network Journals
Posted on: Wednesday, May 08, 2013, 8:15am
Rating: | Views: 1968 | Comments: 0
Exercise-related changes in estrogen metabolism may lower breast cancer risk
Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Cancer
Source: American Association for Cancer Research
Posted on: Tuesday, May 07, 2013, 4:45pm
Rating: | Views: 1987 | Comments: 0
Source: American Association for Cancer Research
Posted on: Tuesday, May 07, 2013, 4:45pm
Rating: | Views: 1987 | Comments: 0
Activity of cancer inducing genes can be controlled by the cell's skeleton
Cancer is a complex disease, in which cells undergo a series of alterations, including changes in their architecture; an increase in their ability to divide, to survive and to invade new tissues or metastasis. A category of genes, called oncogenes, is critical during cancer progression, as they codify proteins whose activity favours the development of cancer. One of these molecules, Src, is implic
Cancer is a complex disease, in which cells undergo a series of alterations, including changes in their architecture; an increase in their ability to divide, to survive and to invade new tissues or metastasis. A category of genes, called oncogenes, is critical during cancer progression, as they codify proteins whose activity favours the development of cancer. One of these molecules, Src, is implic
Molecular Biology
Source: Instituto Gulbenkian de Ciencia
Posted on: Tuesday, May 07, 2013, 4:15pm
Rating: | Views: 2053 | Comments: 0
Source: Instituto Gulbenkian de Ciencia
Posted on: Tuesday, May 07, 2013, 4:15pm
Rating: | Views: 2053 | Comments: 0
New class of drug targets skin cancer
A new class of drug targeting skin cancer's genetic material has been successfully tested in humans for the first time, opening the way to new treatments for a range of conditions from skin cancers to eye diseases.
A new class of drug targeting skin cancer's genetic material has been successfully tested in humans for the first time, opening the way to new treatments for a range of conditions from skin cancers to eye diseases.
Cancer
Source: University of New South Wales
Posted on: Tuesday, May 07, 2013, 1:45pm
Rating: | Views: 1595 | Comments: 0
Source: University of New South Wales
Posted on: Tuesday, May 07, 2013, 1:45pm
Rating: | Views: 1595 | Comments: 0
Wip1 could be new target for cancer treatment
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers.
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers.
Cancer
Source: Rockefeller University Press
Posted on: Tuesday, May 07, 2013, 12:45pm
Rating: | Views: 1534 | Comments: 0
Source: Rockefeller University Press
Posted on: Tuesday, May 07, 2013, 12:45pm
Rating: | Views: 1534 | Comments: 0
New antiviral treatment could significantly reduce global burden of hepatitis C
Around 150 million people globally are chronically infected with the hepatitis C virus (HCV) – a major cause of liver disease and the fastest growing cause of liver transplantation and liver cancer. 1 New prevention strategies are urgently required as people are continuing to be infected with HCV. Findings, published in Hepatology, reveal the impact of a new antiviral treatment that could
Around 150 million people globally are chronically infected with the hepatitis C virus (HCV) – a major cause of liver disease and the fastest growing cause of liver transplantation and liver cancer. 1 New prevention strategies are urgently required as people are continuing to be infected with HCV. Findings, published in Hepatology, reveal the impact of a new antiviral treatment that could
Epidemiology
Source: University of Bristol
Posted on: Tuesday, May 07, 2013, 10:45am
Rating: | Views: 2127 | Comments: 0
Source: University of Bristol
Posted on: Tuesday, May 07, 2013, 10:45am
Rating: | Views: 2127 | Comments: 0
Researchers discover new target for personalized cancer therapy
A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine have developed a novel method to disrupt this growth signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers.
A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine have developed a novel method to disrupt this growth signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers.
Cancer
Source: Case Western Reserve University
Posted on: Friday, May 03, 2013, 1:30pm
Rating: | Views: 5893 | Comments: 0
Source: Case Western Reserve University
Posted on: Friday, May 03, 2013, 1:30pm
Rating: | Views: 5893 | Comments: 0
'Dark genome' is involved in Rett Syndrome
Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding long chain RNA sequences (lncRNA) in Rett syndrome.
Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding long chain RNA sequences (lncRNA) in Rett syndrome.
Molecular Biology
Source: IDIBELL-Bellvitge Biomedical Research Institute
Posted on: Friday, May 03, 2013, 12:15pm
Rating: | Views: 1893 | Comments: 0
Source: IDIBELL-Bellvitge Biomedical Research Institute
Posted on: Friday, May 03, 2013, 12:15pm
Rating: | Views: 1893 | Comments: 0
Focus on STD, not cancer prevention, to promote HPV vaccine use
The HPV vaccine can prevent both cervical cancer and a nasty sexually transmitted disease in women. But emphasizing the STD prevention will persuade more young women to get the vaccine, a new study suggests.
The HPV vaccine can prevent both cervical cancer and a nasty sexually transmitted disease in women. But emphasizing the STD prevention will persuade more young women to get the vaccine, a new study suggests.
Health
Source: Ohio State University
Posted on: Friday, May 03, 2013, 12:00pm
Rating: | Views: 1479 | Comments: 0
Source: Ohio State University
Posted on: Friday, May 03, 2013, 12:00pm
Rating: | Views: 1479 | Comments: 0
Scripps Research Institute scientists find dissimilar proteins evolved similar 7-part shape
Solving the structure of a critical human molecule involved in cancer, scientists at The Scripps Research Institute (TSRI) have found what they call a good example of structural conservation—dissimilar genes that keep very similar shapes.
Solving the structure of a critical human molecule involved in cancer, scientists at The Scripps Research Institute (TSRI) have found what they call a good example of structural conservation—dissimilar genes that keep very similar shapes.
Evolution
Source: Scripps Research Institute
Posted on: Thursday, May 02, 2013, 1:00pm
Rating: | Views: 1886 | Comments: 0
Source: Scripps Research Institute
Posted on: Thursday, May 02, 2013, 1:00pm
Rating: | Views: 1886 | Comments: 0
Scientists assemble genetic playbook for acute leukemia
A team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia (AML), a fast-growing blood cancer in adults that often is difficult to treat.
A team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia (AML), a fast-growing blood cancer in adults that often is difficult to treat.
Cancer
Source: Washington University School of Medicine
Posted on: Thursday, May 02, 2013, 12:00pm
Rating: | Views: 1368 | Comments: 0
Source: Washington University School of Medicine
Posted on: Thursday, May 02, 2013, 12:00pm
Rating: | Views: 1368 | Comments: 0
A shift in endometrial cancer
A study from the Cancer Genome Atlas Research Network, led by the National Cancer Institute and the National Human Genome Research Institute, report that mutations discovered in endometrial cancer genes may directly impact treatment plans for women with aggressive endometrial cancer, as well as the classification of endometrial cancer tumors.
A study from the Cancer Genome Atlas Research Network, led by the National Cancer Institute and the National Human Genome Research Institute, report that mutations discovered in endometrial cancer genes may directly impact treatment plans for women with aggressive endometrial cancer, as well as the classification of endometrial cancer tumors.
Cancer
Source: Brigham and Women's Hospital
Posted on: Thursday, May 02, 2013, 11:30am
Rating: | Views: 1465 | Comments: 0
Source: Brigham and Women's Hospital
Posted on: Thursday, May 02, 2013, 11:30am
Rating: | Views: 1465 | Comments: 0
How some cancers 'poison the soil' to block metastasis
Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are able to generate fertile soil (the microenvironment) in distant organs that promotes cancer's spread. However, this concept does not explain why som
Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are able to generate fertile soil (the microenvironment) in distant organs that promotes cancer's spread. However, this concept does not explain why som
Cancer
Source: Weill Cornell Medical College
Posted on: Wednesday, May 01, 2013, 12:45pm
Rating: | Views: 1339 | Comments: 0
Source: Weill Cornell Medical College
Posted on: Wednesday, May 01, 2013, 12:45pm
Rating: | Views: 1339 | Comments: 0
Experimental drug inhibits growth in all stages of common kidney cancer
Researchers at Mayo Clinic's campus in Florida have discovered a protein that is overly active in every human sample of kidney cancer they examined. They also found that an experimental drug designed to block the protein's activity significantly reduced tumor growth in animals when used alone. Combining it with another drug already used to treat the cancer improved the effecti
Researchers at Mayo Clinic's campus in Florida have discovered a protein that is overly active in every human sample of kidney cancer they examined. They also found that an experimental drug designed to block the protein's activity significantly reduced tumor growth in animals when used alone. Combining it with another drug already used to treat the cancer improved the effecti
Cancer
Source: Mayo Clinic
Posted on: Wednesday, May 01, 2013, 11:15am
Rating: | Views: 2984 | Comments: 0
Source: Mayo Clinic
Posted on: Wednesday, May 01, 2013, 11:15am
Rating: | Views: 2984 | Comments: 0
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