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Diabetes and cancer: A shared biological basis
Contrary to what you might think, cancer and diabetes appear to have some biology in common. According to a report in the September 30th issue of the Cell Press journal, Cell, a pathway that initially drew attention for its role in embryonic stem cells and cancer also influences the odds that mice develop or resist diabetes.
Molecular Biology
Source: Cell Press
Posted on: Thursday, Sep 29, 2011, 2:15pm
Rating: | Views: 1143 | Comments: 0
Correcting sickle cell disease with stem cells
Using a patient's own stem cells, researchers at Johns Hopkins have corrected the genetic alteration that causes sickle cell disease (SCD), a painful, disabling inherited blood disorder that affects mostly African-Americans. The corrected stem cells were coaxed into immature red blood cells in a test tube that then turned on a normal version of the gene.
Agriculture
Source: Johns Hopkins Medical Institutions
Posted on: Thursday, Sep 29, 2011, 11:15am
Rating: | Views: 1177 | Comments: 0
Scientists identify new stem cell activity in human brain
Researchers at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center have identified a new pathway of stem cell activity in the brain that represents potential targets of brain injuries affecting newborns. The recent study, which raises new questions of how the brain evolves, is published in the current issue of Nature, one of the world's most cited scientific journals.
Stem cells
Source: St. Joseph's Hospital and Medical Center
Posted on: Thursday, Sep 29, 2011, 8:15am
Rating: | Views: 1112 | Comments: 0
Research reveals how dynamic changes in methylation can determine cell fate
Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of Southern California (USC) have uncovered intriguing new evidence helping to explain one of the ways in which a stem cell's fate can be determined.
Molecular Biology
Source: Cold Spring Harbor Laboratory
Posted on: Monday, Sep 26, 2011, 5:15pm
Rating: | Views: 1132 | Comments: 0
U.K. Approves Europe's First Embryonic Stem Cell Clinical Trial
A U.S.-based company has received permission to start Europe's first clinical trial involving human embryonic stem (hES) cells. Advanced Cell Technology (ACT), based in Marlborough, Massachusetts, received approval today from the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to begin a trial that will treat 12 patients with Stargardt's macular dystrophy.
Stem cells
Source: Science
Posted on: Friday, Sep 23, 2011, 7:55am
Rating: | Views: 1121 | Comments: 0
Bioengineers reprogram muscles to combat degeneration
Researchers at the University of California, Berkeley, have turned back the clock on mature muscle tissue, coaxing it back to an earlier stem cell stage to form new muscle. Moreover, they showed in mice that the newly reprogrammed muscle stem cells could be used to help repair damaged tissue.
Molecular Biology
Source: University of California - Berkeley
Posted on: Thursday, Sep 22, 2011, 1:30pm
Rating: | Views: 1346 | Comments: 0
Stem Cell Lawsuit Back Again
As expected, the plaintiffs in a law suit claiming that federally funded research on human embryonic stem cells (hESC) is illegal have appealed a ruling that dealt them a defeat earlier this summer.
Stem cells
Source: Science
Posted on: Tuesday, Sep 20, 2011, 8:19am
Rating: | Views: 1103 | Comments: 0
New type of spinal cord stem cell discovered
A group led by a University of British Columbia and Vancouver Coastal Health scientist has discovered a type of spinal cord cell that could function as a stem cell, with the ability to regenerate portions of the central nervous system in people with spinal cord injuries, multiple sclerosis or amyotrophic lateral sclerosis (Lou Gehrig's disease).
Stem cells
Source: University of British Columbia
Posted on: Thursday, Sep 15, 2011, 6:22pm
Rating: | Views: 1084 | Comments: 0
New class of stem cell-like cells discovered offers possibility for spinal cord repair
The Allen Institute for Brain Science announced today the discovery of a new class of cells in the spinal cord that act like neural stem cells, offering a fresh avenue in the search for therapies to treat spinal cord injury and disease.
Stem cells
Source: Allen Institute for Brain Science
Posted on: Thursday, Sep 15, 2011, 11:45am
Rating: | Views: 1334 | Comments: 0
Shaping up: Controlling a stem cell's form can determine its fate
"Form follows function!" was the credo of early 20th century architects making design choices based on the intended use of the structure. Cell biologists may be turning that on its head. New research reinforces the idea that stem cells can be induced to develop into specific types of cells solely by controlling their shape.
Stem cells
Source: National Institute of Standards and Technology (NIST)
Posted on: Wednesday, Sep 14, 2011, 8:38am
Rating: | Views: 1091 | Comments: 0
Neurosurgeons use adult stem cells to grow neck vertebrae
Neurosurgery researchers at UC Davis Health System have used a new, leading-edge stem cell therapy to promote the growth of bone tissue following the removal of cervical discs -- the cushions between the bones in the neck -- to relieve chronic, debilitating pain.
Stem cells
Source: University of California - Davis Health System
Posted on: Wednesday, Sep 07, 2011, 12:45pm
Rating: | Views: 1181 | Comments: 0
Scientists find stem cells that tell hair it's time to grow
Yale researchers have discovered the source of signals that trigger hair growth, an insight that may lead to new treatments for baldness. The researchers identified stem cells within the skin's fatty layer and showed that molecular signals from these cells were necessary to spur hair growth in mice, according to research published in the Sept. 2 issue of the journal Cell. "If we ca
Stem cells
Source: Yale University
Posted on: Thursday, Sep 01, 2011, 4:45pm
Rating: | Views: 1310 | Comments: 0
New research validates clinical importance of leukemia stem cells
Scientists have long debated if all cells within a tumour are equal or whether some cancer cells are more potent - a question that has been highly investigated in experimental models in the last decade. New research shows that acute myeloid leukemia (AML) contains rare cells with stem cell properties, called leukemia stem cells (LSC), that are better at predicting clinical outcome
Cancer
Source: University Health Network
Posted on: Monday, Aug 29, 2011, 11:15am
Rating: | Views: 1180 | Comments: 0
An RNA Switch for Stem Cells
A new study reveals the influence of large RNA molecules in controlling stem cells. RNA molecules have long been known for their role in translating genes to proteins inside a cell, but more recently, scientists have found large numbers of RNA molecules that don't code for proteins but seem to have other cellular roles. Most research in mammals has focused on tiny RNA molecules called microRNAs, but a new study, published this week in Nature, describes the far-reaching effects of much larger and relatively unstudied RNA molecules called lincRNAs (short for large intergenic noncoding RNAs). The study identifies lincRNAs that play a role in the function of embryonic stem cells, and suggests trying to use lincRNAs to manipulate these cells to spawn other cell types.
Molecular Biology
Source: Technology Review
Posted on: Monday, Aug 29, 2011, 7:53am
Rating: | Views: 1088 | Comments: 0
Molecular chaperones traffic signaling proteins between cells in plant stem-cell maintenance pathway
Like all living things, plants depend for their growth and sustenance on elaborate signaling networks to maintain stem cells, cells that have an almost magical regenerative capacity. The signals sent through these networks convey an incredible diversity of instructions, which make it possible for plants to follow genetic and cellular programs regulating growth, shape, and
Molecular Biology
Source: Cold Spring Harbor Laboratory
Posted on: Friday, Aug 26, 2011, 8:15am
Rating: | Views: 1436 | Comments: 0
'Open wide' for new stem cell potential
While highly potent embryonic stem cells are often the subject of ethical and safety controversy, adult-derived stem cells have other problems. As we age, our stem cells are less pliant and less able to transform into the stem cells that science needs to find breakthrough treatments for disease.
Stem cells
Source: American Friends of Tel Aviv University
Posted on: Tuesday, Aug 23, 2011, 12:30pm
Rating: | Views: 1109 | Comments: 0
Cancer stem cells made, not born
In cancer, tumors aren't uniform: they are more like complex societies, each with a unique balance of cancer cell types playing different roles. Understanding this "social structure" of tumors is critical for treatment decisions in the clinic because different cell types may be sensitive to different drugs.
Cancer
Source: Broad Institute of MIT and Harvard
Posted on: Friday, Aug 19, 2011, 5:45pm
Rating: | Views: 1333 | Comments: 0
Cells derived from pluripotent stem cells are developmentally immature
Stem cell researchers at UCLA have discovered that three types of cells derived from human embryonic stem cells and induced pluripotent stem cells are similar to each other, but are much more developmentally immature than previously thought when compared to those same cell types taken directly from human tissue.
Stem cells
Source: University of California - Los Angeles Health Sciences
Posted on: Thursday, Aug 18, 2011, 4:30pm
Rating: | Views: 1088 | Comments: 0
Stem cells central to pathogenesis of mature lymphoid tumors
New research suggests that blood stem cells can be involved in the generation of leukemia, even when the leukemia is caused by the abnormal proliferation of mature cells. The study, published by Cell Press in the August 16th issue of the journal Cancer Cell, may guide future strategies aimed at identifying therapeutic targets for chronic lymphocytic leukemia (CLL).
Cancer
Source: Cell Press
Posted on: Wednesday, Aug 17, 2011, 12:30pm
Rating: | Views: 1122 | Comments: 0
Discovery may eliminate potentially lethal side effect of stem cell therapy
Like fine chefs, scientists are seemingly approaching a day when they will be able to make nearly any type of tissue from human embryonic stem cells. You need nerves or pancreas, bone or skin? With the right combination of growth factors, skill and patience, a laboratory tissue culture dish promises to yield therapeutic wonders.
Stem cells
Source: Stanford University Medical Center
Posted on: Monday, Aug 15, 2011, 10:30am
Rating: | Views: 1173 | Comments: 0
Stem cell scientists uncover for the first time why the human heart can't regenerate itself
Stem cell researchers at UCLA have uncovered for the first time why adult human cardiac myocytes have lost their ability to proliferate, perhaps explaining why the human heart has little regenerative capacity.
Stem cells
Source: University of California - Los Angeles Health Sciences
Posted on: Tuesday, Aug 09, 2011, 1:15pm
Rating: | Views: 1302 | Comments: 0
A patient's own skin cells may one day treat multiple diseases
The possibility of developing stem cells from a patient's own skin and using them to treat conditions as diverse as Parkinson's disease, Alzheimer's disease and cancer has generated tremendous excitement in the stem cell research community in recent years.
Stem cells
Source: University of California - Davis Health System
Posted on: Friday, Aug 05, 2011, 8:15am
Rating: | Views: 1286 | Comments: 0
Researchers find way to help donor adult blood stem cells overcome transplant rejection
Findings by UT Southwestern Medical Center researchers may suggest new strategies for successful donor adult stem cell transplants in patients with blood cancers such as leukemia, lymphoma and myeloma.
Stem cells
Source: UT Southwestern Medical Center
Posted on: Thursday, Aug 04, 2011, 2:15pm
Rating: | Views: 1115 | Comments: 0
Making sperm from stem cells in a dish
Researchers have found a way to turn mouse embryonic stem cells into sperm. This finding, reported in the journal Cell in a special online release on August 4th, opens up new avenues for infertility research and treatment. A Kyoto University team has coaxed mouse embryonic stem cells into sperm precursors, called primordial germ cells (PGCs), and shown that these cells can give rise to he
Stem cells
Source: Cell Press
Posted on: Thursday, Aug 04, 2011, 1:30pm
Rating: | Views: 1130 | Comments: 0
Mitochondrial genome mutates when reprogrammed
Induced pluripotent stem cells (iPS cells) are truly talented multi-taskers. They can reproduce almost all cell types and thus offer great hope in the fight against diseases like Alzheimer's and Parkinson's. However, it would appear that their use is not entirely without risk: during the reprogramming of body cells into iPS cells, disease-causing mutations can creep into the genetic material.
Genetics
Source: Max-Planck-Gesellschaft
Posted on: Thursday, Jul 28, 2011, 1:45pm
Rating: | Views: 1150 | Comments: 0
Scientists complete first mapping of molecule found in human embryonic stem cells
Stem cell researchers at UCLA have generated the first genome-wide mapping of a DNA modification called 5-hydroxymethylcytosine (5hmC) in embryonic stem cells, and discovered that it is predominantly found in genes that are turned on, or active.
Energy
Source: University of California - Los Angeles Health Sciences
Posted on: Friday, Jul 22, 2011, 12:30pm
Rating: | Views: 1150 | Comments: 0
Cancer stem cells recruit normal stem cells to fuel ovarian cancer
Researchers at the University of Michigan Comprehensive Cancer Center have found that a type of normal stem cell fuels ovarian cancer by encouraging cancer stem cells to grow.
Cancer
Source: University of Michigan Health System
Posted on: Monday, Jul 18, 2011, 4:00pm
Rating: | Views: 1232 | Comments: 0
Precision gene targeting in stem cells corrects disease-causing mutations
Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (adult cells that have been reprogrammed to an embryonic stem cell-like state).
Molecular Biology
Source: Whitehead Institute for Biomedical Research
Posted on: Friday, Jul 15, 2011, 2:45pm
Rating: | Views: 1281 | Comments: 1
New technique boosts efficiency of blood cell production from human stem cells
Scientists at the Salk Institute for Biological Studies have developed an improved technique for generating large numbers of blood cells from a patient's own cells. The new technique will be immediately useful in further stem cell studies, and when perfected, could be used in stem cell therapies for a wide variety of conditions including cancers and immune ailments.
Stem cells
Source: Salk Institute
Posted on: Friday, Jul 15, 2011, 2:30pm
Rating: | Views: 1108 | Comments: 0
Efficient process using microrna converts human skin cells into neurons
The addition of two particular gene snippets to a skin cell's usual genetic material is enough to turn that cell into a fully functional neuron, report researchers from the Stanford University School of Medicine. The finding, to be published online July 13 in Nature, is one of just a few recent reports of ways to create human neurons in a lab dish.
Stem cells
Source: Stanford University Medical Center
Posted on: Thursday, Jul 14, 2011, 10:45am
Rating: | Views: 1114 | Comments: 0
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