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Improved adult-derived human stem cells have fewer genetic changes than expected
A team of researchers from Johns Hopkins University and the National Human Genome Research Institute has evaluated the whole genomic sequence of stem cells derived from human bone marrow cells—so-called induced pluripotent stem (iPS) cells—and found that relatively few genetic changes occur during stem cell conversion by an improved method. The findings, reported in the March issue of Cell Stem
Stem cells
Source: Johns Hopkins Medical Institutions
Posted on: Tuesday, May 01, 2012, 2:30pm
Rating: | Views: 1237 | Comments: 0
Team turns scar tissue into heart muscle without using stem cells
Scientists at Duke University Medical Center have shown the ability to turn scar tissue that forms after a heart attack into heart muscle cells using a new process that eliminates the need for stem cell transplant.
Molecular Biology
Source: Duke University Medical Center
Posted on: Friday, Apr 27, 2012, 5:30pm
Rating: | Views: 1255 | Comments: 0
How stem cell therapy can keep the immune system under control
A new study, appearing in Cell Stem Cell and led by researchers at the University of Southern California, outlines the specifics of how autoimmune disorders can be controlled by infusions of mesenchymal stem cells.
Immunology
Source: University of Southern California
Posted on: Friday, Apr 27, 2012, 1:00pm
Rating: | Views: 1478 | Comments: 0
From embryonic stem cells, a sperm replacement and easier path to genetic modification
Researchers reporting in the April 27 issue of the journal Cell, a Cell Press publication, have devised a new and improved method for producing genetically modified animals for use in scientific research. The method relies on haploid embryonic stem cells (haESCs) instead of sperm to artificially fertilize immature egg cells. Such stem cells are similar to sperm in that they carry only genet
Molecular Biology
Source: Cell Press
Posted on: Friday, Apr 27, 2012, 12:30pm
Rating: | Views: 1132 | Comments: 0
Growing up as a neural stem cell: The importance of clinging together and then letting go
Can one feel too attached? Does one need to let go to mature? Neural stem cells have this problem, too.
Neuroscience
Source: University of California - Los Angeles Health Sciences
Posted on: Thursday, Apr 26, 2012, 11:15am
Rating: | Views: 1176 | Comments: 0
New stem cell found in the brain
Researchers at Lund University in Sweden have discovered a new stem cell in the adult brain. These cells can proliferate and form several different cell types - most importantly, they can form new brain cells. Scientists hope to take advantage of the finding to develop methods to heal and repair disease and injury in the brain.
Neuroscience
Source: Van Andel Research Institute
Posted on: Friday, Apr 20, 2012, 2:15pm
Rating: | Views: 1327 | Comments: 0
Texas passes controversial stem cell regulations
Critics worry that Texas's stem cell rules could put patients at risk from unproven therapies
Health
Source: New Scientist
Posted on: Wednesday, Apr 18, 2012, 8:58am
Rating: | Views: 1149 | Comments: 0
Determining a stem cell's fate
What happens to a stem cell at the molecular level that causes it to become one type of cell rather than another? At what point is it committed to that cell fate, and how does it become committed? The answers to these questions have been largely unknown. But now, in studies that mark a major step forward in our understanding of stem cells' fates, a team of researchers from the Cal
Stem cells
Source: California Institute of Technology
Posted on: Thursday, Apr 12, 2012, 2:45pm
Rating: | Views: 1145 | Comments: 0
Big advance against cystic fibrosis
Harvard stem cell researchers at Massachusetts General Hospital (MGH) have taken a critical step in making possible the discovery in the relatively near future of a drug to control cystic fibrosis (CF), a fatal lung disease that claims about 500 lives each year, with 1,000 new cases diagnosed annually.
Molecular Biology
Source: Massachusetts General Hospital
Posted on: Friday, Apr 06, 2012, 12:15pm
Rating: | Views: 1201 | Comments: 0
Researchers derive purified lung and thyroid progenitors from embryonic stem cells
Researchers at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have derived a population of pure lung and thyroid progenitor cells in vitro that successfully mimic the developmental milestones of lung and thyroid tissue formation. The research, which will be published in the April 6 edition of the journal Cell Stem Cell, identifies factors necessary fo
Stem cells
Source: Boston University Medical Center
Posted on: Friday, Apr 06, 2012, 10:15am
Rating: | Views: 1202 | Comments: 0
To prevent leukemia's dreaded return, go for the stem cells
Researchers reporting in the April Cell Stem Cell, a Cell Press publication, have found a way to stop leukemia stem cells in their tracks. The advance in mice suggests that a combination approach to therapy might stamp out chronic myeloid leukemia (CML) for good.
Stem cells
Source: Cell Press
Posted on: Friday, Apr 06, 2012, 8:00am
Rating: | Views: 1142 | Comments: 0
Arsenic turns stem cells cancerous, spurring tumor growth
Researchers at the National Institutes of Health have discovered how exposure to arsenic can turn normal stem cells into cancer stem cells and spur tumor growth. Inorganic arsenic, which affects the drinking water of millions of people worldwide, has been previously shown to be a human carcinogen. A growing body of evidence suggests that cancer is a stem-cell based disease. Normal stem cells are e
Cancer
Source: NIH/National Institute of Environmental Health Sciences
Posted on: Wednesday, Apr 04, 2012, 2:15pm
Rating: | Views: 1137 | Comments: 0
New hormone for lowering blood sugar
New evidence points to a hormone that leaves muscles gobbling up sugar as if they can't get enough. That factor, which can be coaxed out of fat stem cells, could lead to a new treatment to lower blood sugar and improve metabolism, according to a report in the April issue of Cell Metabolism, a Cell Press publication.
Molecular Biology
Source: Cell Press
Posted on: Wednesday, Apr 04, 2012, 11:15am
Rating: | Views: 1221 | Comments: 0
Cancer stem cell vaccine in development shows antitumor effect
Scientists may have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.
Cancer
Source: American Association for Cancer Research
Posted on: Monday, Apr 02, 2012, 12:30pm
Rating: | Views: 1202 | Comments: 0
Somatic stem cells obtained from skin cells for first time ever
Breaking new ground, scientists at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, have succeeded in obtaining somatic stem cells from fully differentiated somatic cells. Stem cell researcher Hans Schöler and his team took skin cells from mice and, using a unique combination of growth factors while ensuring appropriate culturing conditions, have managed to induce the cells'
Stem cells
Source: Max-Planck-Gesellschaft
Posted on: Friday, Mar 23, 2012, 11:45am
Rating: | Views: 1142 | Comments: 0
Epigenetic signatures direct the repair potential of reprogrammed cells
A research team has identified epigenetic signatures, markers on DNA that control transient changes in gene expression, within reprogrammed skin cells. These signatures can predict the expression of a wound-healing protein in reprogrammed skin cells or induced pluripotent stem cells (iPSCs), cells that take on embryonic stem cell properties. Understanding how the expressi
Molecular Biology
Source: Tufts University, Health Sciences Campus
Posted on: Thursday, Mar 15, 2012, 12:45pm
Rating: | Views: 1189 | Comments: 0
Correcting human mitochondrial mutations
Researchers at the UCLA stem cell center and the departments of chemistry and biochemistry and pathology and laboratory medicine have identified, for the first time, a generic way to correct mutations in human mitochondrial DNA by targeting corrective RNAs, a finding with implications for treating a host of mitochondrial diseases.
Agriculture
Source: University of California - Los Angeles Health Sciences
Posted on: Monday, Mar 12, 2012, 4:15pm
Rating: | Views: 1357 | Comments: 0
Scientists find insulin, nutrition prevent blood stem cell differentiation in fruit flies
UCLA stem cell researchers have shown that insulin and nutrition keep blood stem cells from differentiating into mature blood cells in Drosophila, the common fruit fly, a finding that has implications for studying inflammatory response and blood development in response to dietary changes in humans.
Genetics
Source: University of California - Los Angeles Health Sciences
Posted on: Monday, Mar 12, 2012, 11:15am
Rating: | Views: 1173 | Comments: 0
A new approach to treating type I diabetes? Gut cells transformed into insulin factories
A study by Columbia researchers suggests that cells in the patient's intestine could be coaxed into making insulin, circumventing the need for a stem cell transplant. Until now, stem cell transplants have been seen by many researchers as the ideal way to replace cells lost in type I diabetes and to free patients from insulin injections.
Genetics
Source: Columbia University Medical Center
Posted on: Monday, Mar 12, 2012, 10:15am
Rating: | Views: 1234 | Comments: 0
'REST' is crucial for the timing of brain development
Upon fertilisation, a single cell is formed when egg and sperm fuse. Our entire body, with more than 200 specialised cell types and billions of cells are formed from this single cell. It is a scientific mystery how the early stem cells know what cell type to become, but a precise timing of the process is crucial for correct development and function of our body. Researchers across the world chase k
Development
Source: University of Copenhagen
Posted on: Friday, Mar 02, 2012, 4:45pm
Rating: | Views: 1383 | Comments: 0
Planarian genes that control stem cell biology identified
Despite their unassuming appearance, the planarian flatworms in Whitehead Institute Member Peter Reddien's lab are revealing powerful new insights into the biology of stem cells—insights that may eventually help such cells deliver on a promising role in regenerative medicine.
Development
Source: Whitehead Institute for Biomedical Research
Posted on: Friday, Mar 02, 2012, 1:00pm
Rating: | Views: 1885 | Comments: 0
Study reveals basic molecular 'wiring' of stem cells
Despite the promise associated with the therapeutic use of human stem cells, a complete understanding of the mechanisms that control the fundamental question of whether a stem cell becomes a specific cell type within the body or remains a stem cell has—until now—eluded scientists.
Stem cells
Source: University of Georgia
Posted on: Thursday, Mar 01, 2012, 2:45pm
Rating: | Views: 1220 | Comments: 0
Scientists make new discovery on stem cell regulation
A*STAR scientists have for the first time, identified that precise regulation of polyamine levels is critical for embryonic stem cell (ESC) self-renewal – the ability of ESCs to divide indefinitely – and directed differentiation. This paper is crucial for better understanding of ESC regulation and was published in the journal Genes & Development on 1st March by the team of scientists from
Stem cells
Source: Agency for Science, Technology and Research (A*STAR), Singapore
Posted on: Thursday, Mar 01, 2012, 1:15pm
Rating: | Views: 1210 | Comments: 0
Memory formation triggered by stem cell development
Researchers at the RIKEN-MIT Center for Neural Circuit Genetics have discovered an answer to the long-standing mystery of how brain cells can both remember new memories while also maintaining older ones.
Neuroscience
Source: RIKEN
Posted on: Friday, Feb 24, 2012, 11:15am
Rating: | Views: 1118 | Comments: 0
Stem cell study in mice offers hope for treating heart attack patients
A UCSF stem cell study conducted in mice suggests a novel strategy for treating damaged cardiac tissue in patients following a heart attack. The approach potentially could improve cardiac function, minimize scar size, lead to the development of new blood vessels – and avoid the risk of tissue rejection.
Stem cells
Source: University of California - San Francisco
Posted on: Wednesday, Feb 15, 2012, 2:45pm
Rating: | Views: 1124 | Comments: 0
First-of-its-kind stem cell study re-grows healthy heart muscle in heart attack patients
Results from a Cedars-Sinai Heart Institute clinical trial show that treating heart attack patients with an infusion of their own heart-derived cells helps damaged hearts re-grow healthy muscle.
Health
Source: Cedars-Sinai Medical Center
Posted on: Tuesday, Feb 14, 2012, 4:00pm
Rating: | Views: 1224 | Comments: 0
Therapy targets leukemia stem cells
New research takes aim at stubborn cancer stem cells that are thought to be responsible for treatment resistance and relapse. The study, published by Cell Press in the February 14 issue of the journal Cancer Cell, provides insight into mechanisms associated with the survival of leukemia stem cells and identifies a potential therapeutic target that is specific for these dangerously persisten
Cancer
Source: Cell Press
Posted on: Tuesday, Feb 14, 2012, 8:15am
Rating: | Views: 1169 | Comments: 0
Scientists turn skin cells into neural precusors, bypassing stem-cell stage
Mouse skin cells can be converted directly into cells that become the three main parts of the nervous system, according to researchers at the Stanford University School of Medicine. The finding is an extension of a previous study by the same group showing that mouse and human skin cells can be directly converted into functional neurons.
Stem cells
Source: Stanford University Medical Center
Posted on: Tuesday, Jan 31, 2012, 11:45am
Rating: | Views: 1206 | Comments: 0
Researchers induce Alzheimer's neurons from pluripotent stem cells
Led by researchers at the University of California, San Diego School of Medicine, scientists have, for the first time, created stem cell-derived, in vitro models of sporadic and hereditary Alzheimer's disease (AD), using induced pluripotent stem cells from patients with the much-dreaded neurodegenerative disorder.
Neuroscience
Source: University of California - San Diego
Posted on: Thursday, Jan 26, 2012, 11:15am
Rating: | Views: 1152 | Comments: 0
Scientists report first step in strategy for cell replacement therapy in Parkinson's disease
Induced pluripotent stem cells (iPSC) are a promising avenue for cell replacement therapy in neurologic diseases. For example, mouse and human iPSCs have been used to generate dopaminergic (DA) neurons that improve symptoms in rat Parkinson's disease models. Reporting in the current issue of the Journal of Parkinson's Disease, a group of scientists from Japan e
Neuroscience
Source: IOS Press
Posted on: Wednesday, Jan 25, 2012, 8:30am
Rating: | Views: 1188 | Comments: 0
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