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New malaria protein structure upends theory of how cells grow and move 
Researchers from the Walter and Eliza Hall Institute have overturned conventional wisdom on how cell movement across all species is controlled, solving the structure of a protein that cuts power to the cell 'motor'. The protein could be a potential drug target for future malaria and anti-cancer treatments.
Researchers from the Walter and Eliza Hall Institute have overturned conventional wisdom on how cell movement across all species is controlled, solving the structure of a protein that cuts power to the cell 'motor'. The protein could be a potential drug target for future malaria and anti-cancer treatments.
Biochemistry
Source: Walter and Eliza Hall Institute
Posted on: Tuesday, May 31, 2011, 11:15am
Rating: | Views: 1156 | Comments: 0
Source: Walter and Eliza Hall Institute
Posted on: Tuesday, May 31, 2011, 11:15am
Rating: | Views: 1156 | Comments: 0
Atomic-scale structures of ribosome could help improve antibiotics
It sounds like hype from a late-night infomercial: It can twist and bend without breaking! And wait, there's more: It could someday help you fend off disease!
It sounds like hype from a late-night infomercial: It can twist and bend without breaking! And wait, there's more: It could someday help you fend off disease!
Biochemistry
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Friday, May 20, 2011, 11:45am
Rating: | Views: 1150 | Comments: 0
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Friday, May 20, 2011, 11:45am
Rating: | Views: 1150 | Comments: 0
Packaging process for genes discovered in new research
Scientists at Penn State University have achieved a major milestone in the attempt to assemble, in a test tube, entire chromosomes from their component parts. The achievement reveals the process a cell uses to package the basic building blocks of an organism's entire genetic code -- its genome.
Scientists at Penn State University have achieved a major milestone in the attempt to assemble, in a test tube, entire chromosomes from their component parts. The achievement reveals the process a cell uses to package the basic building blocks of an organism's entire genetic code -- its genome.
Biochemistry
Source: Penn State
Posted on: Friday, May 20, 2011, 10:15am
Rating: | Views: 1178 | Comments: 0
Source: Penn State
Posted on: Friday, May 20, 2011, 10:15am
Rating: | Views: 1178 | Comments: 0
Errors in protein structure sparked evolution of biological complexity
Over four billion years of evolution, plants and animals grew far more complex than their single-celled ancestors. But a new comparison of proteins shared across species finds that complex organisms, including humans, have accumulated structural weaknesses that may have actually launched the long journey from microbe to man.
Over four billion years of evolution, plants and animals grew far more complex than their single-celled ancestors. But a new comparison of proteins shared across species finds that complex organisms, including humans, have accumulated structural weaknesses that may have actually launched the long journey from microbe to man.
Biochemistry
Source: University of Chicago Medical Center
Posted on: Wednesday, May 18, 2011, 4:30pm
Rating: | Views: 1173 | Comments: 0
Source: University of Chicago Medical Center
Posted on: Wednesday, May 18, 2011, 4:30pm
Rating: | Views: 1173 | Comments: 0
Serendipity leads to lifesaving discovery
About two years ago, Dr. Philippe Gros, a McGill University professor in the Department of Biochemistry and a Principal Investigator in thd McGill Life Sciences Complex, described a mouse mutant that was immunodeficient and hypersensitive to the Bacille Calmette-Guérin (BCG) vaccine and to tuberculosis (TB).
About two years ago, Dr. Philippe Gros, a McGill University professor in the Department of Biochemistry and a Principal Investigator in thd McGill Life Sciences Complex, described a mouse mutant that was immunodeficient and hypersensitive to the Bacille Calmette-Guérin (BCG) vaccine and to tuberculosis (TB).
Genetics
Source: McGill University
Posted on: Wednesday, May 11, 2011, 12:30pm
Rating: | Views: 1134 | Comments: 0
Source: McGill University
Posted on: Wednesday, May 11, 2011, 12:30pm
Rating: | Views: 1134 | Comments: 0
Research reveals how cancer-driving enzyme works
Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth.
Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth.
Biochemistry
Source: UT Southwestern Medical Center
Posted on: Friday, May 06, 2011, 12:30pm
Rating: | Views: 1121 | Comments: 0
Source: UT Southwestern Medical Center
Posted on: Friday, May 06, 2011, 12:30pm
Rating: | Views: 1121 | Comments: 0
Several baffling puzzles in protein molecular structure solved with new method
The structures of many protein molecules remain unsolved even after experts apply an extensive array of approaches. An international collaboration has led to a new, high-performance method that rapidly determined the structure of protein molecules in several cases where previous methods had failed.
The structures of many protein molecules remain unsolved even after experts apply an extensive array of approaches. An international collaboration has led to a new, high-performance method that rapidly determined the structure of protein molecules in several cases where previous methods had failed.
Biochemistry
Source: University of Washington
Posted on: Monday, May 02, 2011, 11:15am
Rating: | Views: 1135 | Comments: 0
Source: University of Washington
Posted on: Monday, May 02, 2011, 11:15am
Rating: | Views: 1135 | Comments: 0
Biologists reveal molecular architecture of key NMDA receptor subunit
Structural biologists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at Emory University have determined the molecular structure of a key portion, or subunit, of a receptor type commonly expressed in brain cells.
Structural biologists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at Emory University have determined the molecular structure of a key portion, or subunit, of a receptor type commonly expressed in brain cells.
Biochemistry
Source: Cold Spring Harbor Laboratory
Posted on: Tuesday, Apr 26, 2011, 1:30pm
Rating: | Views: 1137 | Comments: 0
Source: Cold Spring Harbor Laboratory
Posted on: Tuesday, Apr 26, 2011, 1:30pm
Rating: | Views: 1137 | Comments: 0
TB discovery paves the way for drugs that prevent lung destruction
Scientists have identified a key enzyme responsible for destroying lung tissue in tuberculosis (TB), they report today in the Journal of Clinical Investigation. Drugs that inhibit this enzyme are already available, meaning that the finding could lead quickly to new treatments.
Scientists have identified a key enzyme responsible for destroying lung tissue in tuberculosis (TB), they report today in the Journal of Clinical Investigation. Drugs that inhibit this enzyme are already available, meaning that the finding could lead quickly to new treatments.
Biochemistry
Source: Imperial College London
Posted on: Monday, Apr 25, 2011, 12:15pm
Rating: | Views: 1130 | Comments: 0
Source: Imperial College London
Posted on: Monday, Apr 25, 2011, 12:15pm
Rating: | Views: 1130 | Comments: 0
Researchers get a first look at the mechanics of membrane proteins
In two new studies, researchers provide the first detailed view of the elaborate chemical and mechanical interactions that allow the ribosome – the cell's protein-building machinery – to insert a growing protein into the cellular membrane.
In two new studies, researchers provide the first detailed view of the elaborate chemical and mechanical interactions that allow the ribosome – the cell's protein-building machinery – to insert a growing protein into the cellular membrane.
Biochemistry
Source: University of Illinois at Urbana-Champaign
Posted on: Monday, Apr 18, 2011, 8:30am
Rating: | Views: 1125 | Comments: 0
Source: University of Illinois at Urbana-Champaign
Posted on: Monday, Apr 18, 2011, 8:30am
Rating: | Views: 1125 | Comments: 0
Video: Secrets of a precision protein machine
DNA replication is critical to the life of all organisms, insuring that each new cell, as well as each new offspring, gets an accurate copy of the genome. Among the legions of proteins that do the work so essential to a cell's survival, the DNA-slicing "flap endonuclease" FEN1 plays a key role.
DNA replication is critical to the life of all organisms, insuring that each new cell, as well as each new offspring, gets an accurate copy of the genome. Among the legions of proteins that do the work so essential to a cell's survival, the DNA-slicing "flap endonuclease" FEN1 plays a key role.
Biochemistry
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Friday, Apr 15, 2011, 1:30pm
Rating: | Views: 1170 | Comments: 0
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Friday, Apr 15, 2011, 1:30pm
Rating: | Views: 1170 | Comments: 0
A safer treatment could be realized for millions suffering from parasite infection
A safer and more effective treatment for 10 million people in developing countries who suffer from infections caused by trypanosome parasites could become a reality thanks to new research from Queen Mary, University of London.
A safer and more effective treatment for 10 million people in developing countries who suffer from infections caused by trypanosome parasites could become a reality thanks to new research from Queen Mary, University of London.
Biochemistry
Source: Queen Mary, University of London
Posted on: Friday, Apr 15, 2011, 11:15am
Rating: | Views: 1138 | Comments: 0
Source: Queen Mary, University of London
Posted on: Friday, Apr 15, 2011, 11:15am
Rating: | Views: 1138 | Comments: 0
Discovery of 2 new genes provides hope for stemming Staph infections
The discovery of two genes that encode copper- and sulfur-binding repressors in the hospital terror Staphylococcus aureus means two new potential avenues for controlling the increasingly drug-resistant bacterium, scientists say in the April 15, 2011 issue of the Journal of Biological Chemistry.
The discovery of two genes that encode copper- and sulfur-binding repressors in the hospital terror Staphylococcus aureus means two new potential avenues for controlling the increasingly drug-resistant bacterium, scientists say in the April 15, 2011 issue of the Journal of Biological Chemistry.
Biochemistry
Source: Indiana University
Posted on: Tuesday, Apr 12, 2011, 1:45pm
Rating: | Views: 1104 | Comments: 0
Source: Indiana University
Posted on: Tuesday, Apr 12, 2011, 1:45pm
Rating: | Views: 1104 | Comments: 0
Scientists flex their muscles to solve an old problem
In a famous experiment first performed more than 220 years ago, Italian physician Luigi Galvani discovered that the muscles of a frog's leg twitch when an electric voltage is applied. An international group of scientists from Italy, the UK and France has now brought this textbook classic into the era of nanoscience.
In a famous experiment first performed more than 220 years ago, Italian physician Luigi Galvani discovered that the muscles of a frog's leg twitch when an electric voltage is applied. An international group of scientists from Italy, the UK and France has now brought this textbook classic into the era of nanoscience.
Biochemistry
Source: European Synchrotron Radiation Facility
Posted on: Monday, Apr 11, 2011, 4:45pm
Rating: | Views: 1122 | Comments: 0
Source: European Synchrotron Radiation Facility
Posted on: Monday, Apr 11, 2011, 4:45pm
Rating: | Views: 1122 | Comments: 0
Positioning enzymes with ease
Virtually all processes in the human body rely on a unique class of proteins known as enzymes. To study them, scientists want to attach these molecules to surfaces and hold them fast, but this can often be a tricky undertaking.
Virtually all processes in the human body rely on a unique class of proteins known as enzymes. To study them, scientists want to attach these molecules to surfaces and hold them fast, but this can often be a tricky undertaking.
Biochemistry
Source: Arizona State University
Posted on: Monday, Apr 11, 2011, 12:30pm
Rating: | Views: 1142 | Comments: 0
Source: Arizona State University
Posted on: Monday, Apr 11, 2011, 12:30pm
Rating: | Views: 1142 | Comments: 0
Scientists uncover new DNA role in modifying gene function
For years, scientists have thought of DNA as a passive blueprint capable only of producing specific proteins through RNA transcription. Now, research led by scientists from the Florida campus of The Scripps Research Institute has shown DNA can also act to fine-tune the activity of certain proteins known as nuclear receptors.
For years, scientists have thought of DNA as a passive blueprint capable only of producing specific proteins through RNA transcription. Now, research led by scientists from the Florida campus of The Scripps Research Institute has shown DNA can also act to fine-tune the activity of certain proteins known as nuclear receptors.
Biochemistry
Source: Scripps Research Institute
Posted on: Monday, Apr 11, 2011, 10:45am
Rating: | Views: 1091 | Comments: 0
Source: Scripps Research Institute
Posted on: Monday, Apr 11, 2011, 10:45am
Rating: | Views: 1091 | Comments: 0
Video: Structure formed by strep protein can trigger toxic shock
Infection with some strains of strep turn deadly when a protein found on their surface triggers a widespread inflammatory reaction.
Infection with some strains of strep turn deadly when a protein found on their surface triggers a widespread inflammatory reaction.
Biochemistry
Source: University of California - San Diego
Posted on: Wednesday, Apr 06, 2011, 2:00pm
Rating: | Views: 1201 | Comments: 0
Source: University of California - San Diego
Posted on: Wednesday, Apr 06, 2011, 2:00pm
Rating: | Views: 1201 | Comments: 0
Protein adaptation shows that life on early earth lived in a hot, acidic environment
A new study reveals that a group of ancient enzymes adapted to substantial changes in ocean temperature and acidity during the last four billion years, providing evidence that life on Early Earth evolved from a much hotter, more acidic environment to the cooler, less acidic global environment that exists today.
A new study reveals that a group of ancient enzymes adapted to substantial changes in ocean temperature and acidity during the last four billion years, providing evidence that life on Early Earth evolved from a much hotter, more acidic environment to the cooler, less acidic global environment that exists today.
Biochemistry
Source: Georgia Institute of Technology Research News
Posted on: Tuesday, Apr 05, 2011, 1:00pm
Rating: | Views: 1112 | Comments: 0
Source: Georgia Institute of Technology Research News
Posted on: Tuesday, Apr 05, 2011, 1:00pm
Rating: | Views: 1112 | Comments: 0
Formaldehyde: Poison could have set the stage for the origins of life
Formaldehyde, a poison and a common molecule throughout the universe, is likely the source of the solar system's organic carbon solids—abundant in both comets and asteroids. Scientists have long speculated about the how organic, or carbon-containing, material became a part of the solar system's fabric.
Formaldehyde, a poison and a common molecule throughout the universe, is likely the source of the solar system's organic carbon solids—abundant in both comets and asteroids. Scientists have long speculated about the how organic, or carbon-containing, material became a part of the solar system's fabric.
Biochemistry
Source: Carnegie Institution
Posted on: Tuesday, Apr 05, 2011, 11:15am
Rating: | Views: 1313 | Comments: 1
Source: Carnegie Institution
Posted on: Tuesday, Apr 05, 2011, 11:15am
Rating: | Views: 1313 | Comments: 1
Common 'chaperone' protein found to work in surprising way
In the constantly morphing field of protein structure, scientists at The Scripps Research Institute offer yet another surprise: a common "chaperone" protein in cells thought to help other proteins fold has been shown instead to loosen them.
In the constantly morphing field of protein structure, scientists at The Scripps Research Institute offer yet another surprise: a common "chaperone" protein in cells thought to help other proteins fold has been shown instead to loosen them.
Biochemistry
Source: Scripps Research Institute
Posted on: Monday, Apr 04, 2011, 10:15am
Rating: | Views: 1231 | Comments: 0
Source: Scripps Research Institute
Posted on: Monday, Apr 04, 2011, 10:15am
Rating: | Views: 1231 | Comments: 0
HIV protein unveils vaccine target
An international study headed by a UC Davis scientist describes how a component of a potential HIV vaccine opens like a flower, undergoing one of the most dramatic protein rearrangements yet observed in nature. The finding could reveal new targets for vaccines to prevent HIV infection and AIDS. A paper describing the work was published online this week in the journal Proceedings of the National
An international study headed by a UC Davis scientist describes how a component of a potential HIV vaccine opens like a flower, undergoing one of the most dramatic protein rearrangements yet observed in nature. The finding could reveal new targets for vaccines to prevent HIV infection and AIDS. A paper describing the work was published online this week in the journal Proceedings of the National
Biochemistry
Source: University of California - Davis
Posted on: Thursday, Mar 31, 2011, 11:45am
Rating: | Views: 9776 | Comments: 3
Source: University of California - Davis
Posted on: Thursday, Mar 31, 2011, 11:45am
Rating: | Views: 9776 | Comments: 3
Scientists unlock mystery of how the 22nd amino acid is produced
The most recently discovered amino acid, pyrrolysine, is produced by a series of just three chemical reactions with a single precursor – the amino acid lysine, according to new research.
The most recently discovered amino acid, pyrrolysine, is produced by a series of just three chemical reactions with a single precursor – the amino acid lysine, according to new research.
Biochemistry
Source: Ohio State University
Posted on: Wednesday, Mar 30, 2011, 2:15pm
Rating: | Views: 1423 | Comments: 0
Source: Ohio State University
Posted on: Wednesday, Mar 30, 2011, 2:15pm
Rating: | Views: 1423 | Comments: 0
Researchers make the leap to whole-cell simulations
Researchers have built a computer model of the crowded interior of a bacterial cell that – in a test of its response to sugar in its environment – accurately simulates the behavior of living cells.
Researchers have built a computer model of the crowded interior of a bacterial cell that – in a test of its response to sugar in its environment – accurately simulates the behavior of living cells.
Biochemistry
Source: University of Illinois at Urbana-Champaign
Posted on: Wednesday, Mar 30, 2011, 12:30pm
Rating: | Views: 1117 | Comments: 0
Source: University of Illinois at Urbana-Champaign
Posted on: Wednesday, Mar 30, 2011, 12:30pm
Rating: | Views: 1117 | Comments: 0
Scientists get glimpse of how the 'code' of life may have emerged
A portion of the "code" of life has been unraveled by a UC Santa Barbara graduate student from the town of Jojutla, Mexico.
A portion of the "code" of life has been unraveled by a UC Santa Barbara graduate student from the town of Jojutla, Mexico.
Biochemistry
Source: University of California - Santa Barbara
Posted on: Wednesday, Mar 23, 2011, 1:45pm
Rating: | Views: 1109 | Comments: 0
Source: University of California - Santa Barbara
Posted on: Wednesday, Mar 23, 2011, 1:45pm
Rating: | Views: 1109 | Comments: 0
First image of protein residue in 50 million year old reptile skin
Published in the journal Royal Society Proceedings B: Biology, the brightly-coloured image shows the presence of amides – the organic compounds, or building blocks of life – in the ancient skin of a reptile, found in the 50 million year-old rocks of the Green River Formation in Utah, USA.
Published in the journal Royal Society Proceedings B: Biology, the brightly-coloured image shows the presence of amides – the organic compounds, or building blocks of life – in the ancient skin of a reptile, found in the 50 million year-old rocks of the Green River Formation in Utah, USA.
Biochemistry
Source: University of Manchester
Posted on: Wednesday, Mar 23, 2011, 8:30am
Rating: | Views: 1097 | Comments: 0
Source: University of Manchester
Posted on: Wednesday, Mar 23, 2011, 8:30am
Rating: | Views: 1097 | Comments: 0
Salk scientists crack molecular code regulating neuronal excitability
A key question in protein biochemistry is how proteins recognize "correct" interaction partners in a sea of cellular factors. Nowhere is that more critical to know than in the brain, where interactions governing channel protein activity can alter an organism's behavior.
A key question in protein biochemistry is how proteins recognize "correct" interaction partners in a sea of cellular factors. Nowhere is that more critical to know than in the brain, where interactions governing channel protein activity can alter an organism's behavior.
Biochemistry
Source: Salk Institute
Posted on: Tuesday, Mar 22, 2011, 10:30am
Rating: | Views: 1117 | Comments: 0
Source: Salk Institute
Posted on: Tuesday, Mar 22, 2011, 10:30am
Rating: | Views: 1117 | Comments: 0
Production of mustard oils: On the origin of an enzyme
Plants are continually exposed to herbivore attack. To defend themselves, they have developed sophisticated chemical defense mechanisms. Plants of the mustard family, such as thale cress (Arabidopsis thaliana), produce glucosinolates (mustard oil glucosides) to protect themselves against herbivory.
Plants are continually exposed to herbivore attack. To defend themselves, they have developed sophisticated chemical defense mechanisms. Plants of the mustard family, such as thale cress (Arabidopsis thaliana), produce glucosinolates (mustard oil glucosides) to protect themselves against herbivory.
Biochemistry
Source: Max Planck Institute for Chemical Ecology
Posted on: Thursday, Mar 17, 2011, 10:30am
Rating: | Views: 1106 | Comments: 0
Source: Max Planck Institute for Chemical Ecology
Posted on: Thursday, Mar 17, 2011, 10:30am
Rating: | Views: 1106 | Comments: 0
New laser technique opens doors for drug discovery
A new laser technique has demonstrated that it can measure the interactions between proteins tangled in a cell's membrane and a variety of other biological molecules. These extremely difficult measurements can aid the process of drug discovery.
A new laser technique has demonstrated that it can measure the interactions between proteins tangled in a cell's membrane and a variety of other biological molecules. These extremely difficult measurements can aid the process of drug discovery.
Biochemistry
Source: Vanderbilt University
Posted on: Tuesday, Mar 15, 2011, 2:00pm
Rating: | Views: 1115 | Comments: 0
Source: Vanderbilt University
Posted on: Tuesday, Mar 15, 2011, 2:00pm
Rating: | Views: 1115 | Comments: 0
Finding of long-sought drug target structure may expedite drug discovery
Researchers have solved the three-dimensional structure of a key biological receptor. The finding has the potential to speed drug discovery in many areas, from arthritis to respiratory disorders to wound healing, because it enables chemists to better examine and design molecules for use in experimental drugs.
Researchers have solved the three-dimensional structure of a key biological receptor. The finding has the potential to speed drug discovery in many areas, from arthritis to respiratory disorders to wound healing, because it enables chemists to better examine and design molecules for use in experimental drugs.
Biochemistry
Source: NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Posted on: Tuesday, Mar 15, 2011, 1:30pm
Rating: | Views: 1082 | Comments: 0
Source: NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Posted on: Tuesday, Mar 15, 2011, 1:30pm
Rating: | Views: 1082 | Comments: 0
'Good cholesterol' structure identified, could help explain protective effects
University of Cincinnati (UC) researchers have determined the structure of human HDL cholesterol and say the finding could help explain how this "fat packet" protects against cardiovascular diseases, including heart attack and stroke.
University of Cincinnati (UC) researchers have determined the structure of human HDL cholesterol and say the finding could help explain how this "fat packet" protects against cardiovascular diseases, including heart attack and stroke.
Biochemistry
Source: University of Cincinnati Academic Health Center
Posted on: Monday, Mar 14, 2011, 8:12am
Rating: | Views: 1624 | Comments: 0
Source: University of Cincinnati Academic Health Center
Posted on: Monday, Mar 14, 2011, 8:12am
Rating: | Views: 1624 | Comments: 0
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