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Lack of protein Sp2 disrupts neuron creation in brain
A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to "program" stem cells for regeneration, which has implications for neural therapies.
Development
Source: North Carolina State University
Posted on: Wednesday, Jan 16, 2013, 8:45am
Rating: | Views: 1206 | Comments: 0
Researchers create flexible, nanoscale 'bed of nails' for possible drug delivery
Researchers at North Carolina State University have come up with a technique to embed needle-like carbon nanofibers in an elastic membrane, creating a flexible "bed of nails" on the nanoscale that opens the door to development of new drug-delivery systems.
Materials Science
Source: North Carolina State University
Posted on: Wednesday, Jan 16, 2013, 8:30am
Rating: | Views: 1501 | Comments: 0
Protein identified that can disrupt embryonic brain development and neuron migration
Interneurons – nerve cells that function as 'dimmers' – play an important role in the brain. Their formation and migration to the cerebral cortex during the embryonic stage of development is crucial to normal brain functioning.
Neuroscience
Source: KU Leuven
Posted on: Tuesday, Jan 15, 2013, 10:30am
Rating: | Views: 1189 | Comments: 0
New discovery in autism-related disorder reveals key mechanism in brain development and disease
A new finding in neuroscience for the first time points to a developmental mechanism linking the disease-causing mutation in an autism-related disorder, Timothy syndrome, and observed defects in brain wiring, according to a study led by scientist Ricardo Dolmetsch and published online yesterday in Nature Neuroscience. These findings may be at the heart of the mechanisms underlying intellect
Neuroscience
Source: Allen Institute for Brain Science
Posted on: Tuesday, Jan 15, 2013, 8:30am
Rating: | Views: 1132 | Comments: 0
The secrets of a tadpole's tail and the implications for human healing
Scientists at The University of Manchester have made a surprising finding after studying how tadpoles re-grow their tails which could have big implications for research into human healing and regeneration.
Development
Source: University of Manchester
Posted on: Monday, Jan 14, 2013, 11:30am
Rating: | Views: 1167 | Comments: 0
Video: Molecular machine could hold key to more efficient manufacturing
An industrial revolution on a minute scale is taking place in laboratories at The University of Manchester with the development of a highly complex machine that mimics how molecules are made in nature.
Materials Science
Source: University of Manchester
Posted on: Friday, Jan 11, 2013, 12:15pm
Rating: | Views: 1980 | Comments: 0
Regulating single protein prompts fibroblasts to become neurons
Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells – abundantly found in connective tissues – into functional neurons. The findings, which could have far-reaching implications for the development of new treatments for neurodegenerative diseases like Huntington's, Parkinson's and Alzheimer's, will be published online in advance of the January 17 issue
Neuroscience
Source: University of California - San Diego
Posted on: Friday, Jan 11, 2013, 11:30am
Rating: | Views: 1234 | Comments: 0
First image of insulin 'docking' could lead to better diabetes treatments
A landmark discovery about how insulin docks on cells could help in the development of improved types of insulin for treating both type 1 and type 2 diabetes.
Biochemistry
Source: Walter and Eliza Hall Institute
Posted on: Thursday, Jan 10, 2013, 12:45pm
Rating: | Views: 1340 | Comments: 0
Regeneration of sound sensing cells recovers hearing in mice with noise-induced deafness
Extremely loud noise can cause irreversible hearing loss by damaging sound sensing cells in the inner ear that are not replaced. But researchers reporting in the January 9 issue of the Cell Press journal Neuron have successfully regenerated these cells in mice with noise-induced deafness, partially reversing their hearing loss. The investigators hope the technique may lead to development of
Neuroscience
Source: Cell Press
Posted on: Thursday, Jan 10, 2013, 12:00pm
Rating: | Views: 1353 | Comments: 0
Fussy babies spend more time in front of the TV
Moms, especially those who are obese, are more likely to use TV to entertain and soothe infants who are more fussy and active, according to researchers at the University of North Carolina at Chapel Hill. The finding adds to the growing body of knowledge that may help explain the escalating rate of obesity and inactivity in U.S. children, and has led to behavioral and educational strategies that ma
Development
Source: University of North Carolina at Chapel Hill
Posted on: Wednesday, Jan 09, 2013, 12:15pm
Rating: | Views: 1148 | Comments: 0
Molecular '2-way radio' directs nerve cell branching and connectivity
Working with fruit flies, Johns Hopkins scientists have decoded the activity of protein signals that let certain nerve cells know when and where to branch so that they reach and connect to their correct muscle targets. The proteins' mammalian counterparts are known to have signaling roles in immunity, nervous system and heart development, and tumor progression, suggesting broad implications for hu
Neuroscience
Source: Johns Hopkins Medicine
Posted on: Tuesday, Jan 08, 2013, 1:00pm
Rating: | Views: 1215 | Comments: 0
New study defines the long-sought structure of a protein necessary for cell-cell interaction
Scientists know that cells in all higher organisms cells need to bind to each other for the development, architecture, maintenance and function of tissues. Mysteries have remained, however, about exactly how cells manage this feat.
Molecular Biology
Source: Scripps Research Institute
Posted on: Monday, Jan 07, 2013, 12:45pm
Rating: | Views: 1191 | Comments: 0
Study hints that stem cells prepare for maturity much earlier than anticipated
Unlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility "pluripotency," meaning that as an organism develops, stem cells must be ready at a moment's notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells.
Development
Source: Stowers Institute for Medical Research
Posted on: Wednesday, Jan 02, 2013, 5:15pm
Rating: | Views: 1245 | Comments: 0
Research uncovers new insight into cell development and cancer
Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on
Molecular Biology
Source: University of North Carolina Health Care
Posted on: Wednesday, Jan 02, 2013, 5:00pm
Rating: | Views: 1212 | Comments: 0
New insights into how immune system fights atherosclerosis
A study led by Columbia University Medical Center (CUMC) researchers has found that an important branch of the immune system, in reaction to the development of atherosclerotic lesions, mounts a surprisingly robust anti-inflammatory T cell response that helps prevent the disease from progressing. The findings may help inform the design of anti-atherosclerosis vacc
Health
Source: Columbia University Medical Center
Posted on: Wednesday, Jan 02, 2013, 11:00am
Rating: | Views: 1461 | Comments: 0
Cellular patterns of development
For a tiny embryo to grow into an entire fruit fly, mouse or human, the correct genes in each cell must turn on and off in precisely the right sequence. This intricate molecular dance produces the many parts of the whole creature, from muscles and skin to nerves and blood.
Molecular Biology
Source: Stowers Institute for Medical Research
Posted on: Friday, Dec 21, 2012, 12:15pm
Rating: | Views: 1151 | Comments: 0
The role of the innate immune cells in the development of type 1 diabetes
The researchers reveal the role of the innate immune cells, especially the dendritic cells, that cause the activation of the killer T-lymphocytes whose action is directed against the p pancreatic cells. The results obtained in mice make it possible to consider new ways of regulating the auto-immune reaction generated by the innate immune cells.
Molecular Biology
Source: INSERM (Institut national de la sant� et de la recherche m�dicale)
Posted on: Thursday, Dec 20, 2012, 10:30am
Rating: | Views: 1140 | Comments: 0
Dreidel-like dislocations lead to remarkable properties
A new material structure predicted at Rice University offers the tantalizing possibility of a signal path smaller than the nanowires for advanced electronics now under development at Rice and elsewhere.
Physics
Source: Rice University
Posted on: Monday, Dec 17, 2012, 11:00am
Rating: | Views: 1211 | Comments: 0
What mechanism generates our fingers and toes?
Dr. Marie Kmita and her research team at the IRCM contributed to a multidisciplinary research project that identified the mechanism responsible for generating our fingers and toes, and revealed the importance of gene regulation in the transition of fins to limbs during evolution. Their scientific breakthrough is published today in the prestigious scientific journal
Development
Source: Institut de recherches cliniques de Montreal
Posted on: Monday, Dec 17, 2012, 8:45am
Rating: | Views: 1153 | Comments: 0
Video: New study brings long-sought vaccines for deadly parasite closer to reality
One major cause of illness from food-borne diseases is the parasite Toxoplasma gondii (T. gondii). New insights into how the immune system combats T. gondii are provided in a study published by Cell Press December 13th in the journal Immunity. The findings could lead to the development of long-sought vaccines to protect against T. gondii and related parasites.
Molecular Biology
Source: Cell Press
Posted on: Friday, Dec 14, 2012, 11:00am
Rating: | Views: 1340 | Comments: 0
Researchers identify new components of the epigenetic 'code' for honey bee development
Researchers from the UK and Australia have uncovered a new element of the honeybee's genetic makeup, which may help to explain why bees are so sensitive to environmental changes.
Genetics
Source: University of Sheffield
Posted on: Wednesday, Dec 12, 2012, 10:15am
Rating: | Views: 5156 | Comments: 0
From fish to man: Research reveals how fins became legs
Vertebrates' transition to living on land, instead of only in water, represented a major event in the history of life. Now, researchers reporting in the December issue of the Cell Press journal Developmental Cell provide new evidence that the development of hands and feet occurred through the gain of new DNA elements that activate particular genes.
Evolution
Source: Cell Press
Posted on: Tuesday, Dec 11, 2012, 11:15am
Rating: | Views: 1223 | Comments: 0
Insight into DNA reprogramming during egg and sperm cell development
Scientists at the Babraham Institute have gained a new understanding of when and how the DNA in developing egg and sperm cells is 'reset', in preparation for making a new embryo. It is well known that small chemical groups can be added to DNA to alter gene activity, these modifications to the DNA are acquired during development in the womb and throughout adult life and can arise from changes in en
Development
Source: Biotechnology and Biological Sciences Research Council
Posted on: Friday, Dec 07, 2012, 2:00pm
Rating: | Views: 1289 | Comments: 0
Microchoreography: Researchers use synthetic molecule to guide cellular 'dance'
Johns Hopkins researchers have used a small synthetic molecule to stimulate cells to move and change shape, bypassing the cells' usual way of sensing and responding to their environment. The experiment pioneers a new tool for studying cell movement, a phenomenon involved in everything from development to immunity to the spread of cancer.
Chemistry
Source: Johns Hopkins Medicine
Posted on: Thursday, Dec 06, 2012, 11:45am
Rating: | Views: 1586 | Comments: 0
Africa's Homo sapiens were the first techies
The search for the origin of modern human behaviour and technological advancement among our ancestors in southern Africa some 70 000 years ago, has taken a step closer to firmly establishing Africa, and especially South Africa, as the primary centre for the early development of human behaviour.
Anthropology
Source: University of the Witwatersrand
Posted on: Thursday, Dec 06, 2012, 8:45am
Rating: | Views: 2004 | Comments: 0
'Junk DNA' drives embryonic development
An embryo is an amazing thing. From just one initial cell, an entire living, breathing body emerges, full of working cells and organs. It comes as no surprise that embryonic development is a very carefully orchestrated process—everything has to fall into the right place at the right time. Developmental and cell biologists study this very thing, unraveling the m
Molecular Biology
Source: Sanford-Burnham Medical Research Institute
Posted on: Tuesday, Dec 04, 2012, 8:45am
Rating: | Views: 1442 | Comments: 0
Researchers discover master regulator of skin development
The surface of your skin, called the epidermis, is a complex mixture of many different cell types — each with a very specific job. The production, or differentiation, of such a sophisticated tissue requires an immense amount of coordination at the cellular level, and glitches in the process can have disastrous consequences. Now, researchers at the Stanford University School of M
Genetics
Source: Stanford University Medical Center
Posted on: Monday, Dec 03, 2012, 5:00pm
Rating: | Views: 1256 | Comments: 0
Researchers identify a mechanism for the transformation of colon polyps
The causes underlying the development of certain types of common cancers have not yet been elucidated. In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the teams led by Thanos Halazonetis and Stylianos Antonarakis, professors at the University of Geneva (UNIGE), Switzerland, have sequenced the DNA of biopsied tissue from colon polyps. Th
Cancer
Source: University de Geneve
Posted on: Monday, Dec 03, 2012, 1:15pm
Rating: | Views: 1267 | Comments: 0
X-ray analysis deciphers master regulator important for skin cancer
With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma. The results, published in the scientific journal "Genes & Development", throw new light on the workings of the so-called Microphthalmia-associated Transcription Factor MITF, that is not onl
Genetics
Source: Deutsches Elektronen-Synchrotron DESY
Posted on: Monday, Dec 03, 2012, 1:00pm
Rating: | Views: 1172 | Comments: 0
Biology behind brain development disorder
Researchers have defined the gene responsible for a rare developmental disorder in children. The team showed that rare variation in a gene involved in brain development causes the disorder. This is the first time that this gene, UBE3B, has been linked to a disease.
Genetics
Source: Wellcome Trust Sanger Institute
Posted on: Friday, Nov 30, 2012, 1:30pm
Rating: | Views: 1592 | Comments: 0
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