banner
News Archive Search
The dance of the chaperones
Proteins are the molecular building blocks and machinery of cells and involved in practically all biological processes. To fulfil their tasks, they need to be folded into a complicated three-dimensional structure.
Biochemistry
Source: Max-Planck-Gesellschaft
Posted on: Friday, Mar 09, 2012, 11:00am
Rating: | Views: 1205 | Comments: 0
From mouse to man: Circadian nitrogen balance impacts survival and susceptibility to common diseases
Researchers at Case Western Reserve University School of Medicine demonstrated that nitrogen balance, the process of utilizing amino acids and disposing of their toxic byproducts, occurs with a precise 24-hour rhythm – also known as circadian rhythm – in mammals. Disruption of this cycle has a direct impact on survival of organisms, and may predispose one to life altering diseases including diabet
Biochemistry
Source: Case Western Reserve University
Posted on: Wednesday, Mar 07, 2012, 12:00pm
Rating: | Views: 1245 | Comments: 0
More effective method of imaging proteins
Using a unique facility in the US, researchers at the University of Gothenburg have found a more effective way of imaging proteins. The next step is to film how proteins work – at molecular level.
Biochemistry
Source: University of Gothenburg
Posted on: Tuesday, Mar 06, 2012, 1:45pm
Rating: | Views: 1135 | Comments: 0
X-rays reveal how soil bacteria carry out surprising chemistry
Researchers from Singapore, Japan, the UK and USA have discovered how soil bacteria carry out surprising chemistry, defying a longstanding set of chemical rules and thus paving the way for new synthesis of polyether drugs.
Biochemistry
Source: National University of Singapore
Posted on: Monday, Mar 05, 2012, 11:15am
Rating: | Views: 1286 | Comments: 0
Correct protein folding
The gold standard for nanotechnology is nature's own proteins. These biomolecular nanomachines – macromolecules forged from peptide chains of amino acids - are able to fold themselves into a dazzling multitude of shapes and forms that enable them to carry out an equally dazzling multitude of functions fundamental to life. As important as protein folding is to virtually all biological systems, the
Biochemistry
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Monday, Feb 27, 2012, 10:00am
Rating: | Views: 1195 | Comments: 0
Video: Disarming the botulinum neurotoxin
Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) and the Medical School of Hannover in Germany recently discovered how the botulinum neurotoxin, a potential bioterrorism agent, survives the hostile environment in the stomach on its journey through the human body. Their study, published February 24 in Science, reveals the first
Biochemistry
Source: Sanford-Burnham Medical Research Institute
Posted on: Friday, Feb 24, 2012, 12:30pm
Rating: | Views: 1207 | Comments: 0
Researchers reveal role of protein mutation in Parkinson's disease
Purdue University researchers revealed how a mutation in a protein shuts down a protective function needed to prevent the death of neurons in Parkinson's disease, possibly opening the door to new drug strategies to treat the disorder.
Biochemistry
Source: Purdue University
Posted on: Tuesday, Feb 21, 2012, 2:30pm
Rating: | Views: 1320 | Comments: 0
Researchers reveal digital transcriptome of breast cancer
GW Cancer Research Team in the Department of Biochemistry and Molecular Biology, in the School of Medicine and Health Sciences, published a study that is the first of its kind to use mRNA sequencing to look at the expression of genome, at a unprecedented resolution at the current time, in three types of breast cancer. The study titled, "Transcriptomic landscape of breast cancer through mRNA seque
Cancer
Source: George Washington University Medical Center
Posted on: Wednesday, Feb 15, 2012, 8:45am
Rating: | Views: 1569 | Comments: 0
Ultraviolet protection molecule in plants yields its secrets
Lying around in the sun all day is hazardous not just for humans but also for plants, which have no means of escape. Ultraviolet (UV) radiation from the sun can damage proteins and DNA inside cells, leading to poor growth and even death (as well as carcinogenesis in humans). But plants have evolved some powerful adaptive defenses, including a complex array of protective responses or
Biochemistry
Source: Scripps Research Institute
Posted on: Friday, Feb 10, 2012, 1:00pm
Rating: | Views: 1331 | Comments: 0
Biosolar promises cheap, easy green electricity
Barry D. Bruce, professor of biochemistry, cellular and molecular biology, at the University of Tennessee, Knoxville, is turning the term "power plant" on its head. The biochemist and a team of researchers have developed a system that taps into photosynthetic processes to produce efficient and inexpensive energy.
Energy
Source: University of Tennessee at Knoxville
Posted on: Friday, Feb 03, 2012, 10:00am
Rating: | Views: 1842 | Comments: 1
Protein structures give disease clues
Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially leading to new ways to treat or prevent diseases such as breast cancer and Alzheimer's disease.
Biochemistry
Source: University of California - Davis
Posted on: Thursday, Feb 02, 2012, 12:30pm
Rating: | Views: 1191 | Comments: 0
Scientists probe form, function of mysterious protein
Like a magician employing sleight of hand, the protein mitoNEET -- a mysterious but important player in diabetes, cancer and aging -- draws the eye with a flurry of movement in one location while the subtle, more crucial action takes place somewhere else.
Biochemistry
Source: Rice University
Posted on: Friday, Jan 27, 2012, 5:30pm
Rating: | Views: 1292 | Comments: 0
Video: Under the electron microscope - a 3-D image of an individual protein
When Gang Ren whirls the controls of his cryo-electron microscope, he compares it to fine-tuning the gearshift and brakes of a racing bicycle. But this machine at the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) is a bit more complex. It costs nearly $1.5 million, operates at the frigid temperature of liquid nitrogen, and it is allowing scientists to see w
Biochemistry
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Wednesday, Jan 25, 2012, 4:30pm
Rating: | Views: 1341 | Comments: 0
How cells dispose of their waste
Defective proteins that are not disposed of by the body can cause diseases such as Alzheimer's or Parkinson's. Scientists at the Max Planck Institute (MPI) of Biochemistry recently succeeded in revealing the structure of the cellular protein degradation machinery (26S proteasome) by combining different methods of structural biology.
Biochemistry
Source: Max-Planck-Gesellschaft
Posted on: Tuesday, Jan 24, 2012, 11:15am
Rating: | Views: 1200 | Comments: 0
Powerful drug's surprising, simple method could lead to better treatments
With one simple experiment, University of Illinois chemists have debunked a widely held misconception about an often-prescribed drug.
Biochemistry
Source: University of Illinois at Urbana-Champaign
Posted on: Tuesday, Jan 17, 2012, 1:15pm
Rating: | Views: 1216 | Comments: 0
Walk this way: Scientists describe how a motor protein 'steps out'
Just like people, some proteins have characteristic ways of "walking," which (also like human gaits) are not so easy to describe. But now scientists have discovered the unique "drunken sailor" gait of dynein, a protein that is critical for the function of every cell in the body and whose malfunction has been associated with neurodegenerative disorders such as Lou Gehrig's di
Biochemistry
Source: Marine Biological Laboratory
Posted on: Tuesday, Jan 17, 2012, 11:30am
Rating: | Views: 1189 | Comments: 0
Energy-saving chaperon Hsp90
A special group of proteins, the so-called chaperons, helps other proteins to obtain their correct conformation. Until now scientists supposed that hydrolyzing ATP provides the energy for the large conformational changes of chaperon Hsp90. Now a research team from the Nanosystems Initiative Munich could prove that Hsp90 utilizes thermal fluctuations as the driving force for its conformational chan
Biochemistry
Source: Technische Universitaet Muenchen
Posted on: Tuesday, Jan 17, 2012, 10:15am
Rating: | Views: 1250 | Comments: 0
New information on the waste-disposal units of living cells
Important new information on one of the most critical protein machines in living cells has been reported by a team of researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. The researchers have provided the most detailed look ever at the "regulatory particle" used by the protein machines known as proteas
Biochemistry
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Thursday, Jan 12, 2012, 12:45pm
Rating: | Views: 1135 | Comments: 0
Researchers identify molecular 'culprit' in rise of planetary oxygen
A turning point in the history of life occurred 2 to 3 billion years ago with the unprecedented appearance and dramatic rise of molecular oxygen. Now researchers report they have identified an enzyme that was the first – or among the first – to generate molecular oxygen on Earth.
Biochemistry
Source: University of Illinois at Urbana-Champaign
Posted on: Wednesday, Jan 11, 2012, 11:30am
Rating: | Views: 1140 | Comments: 0
Structure of key enzyme important for clearing a potential road block to bisabolane
The recent discovery that bisabolane, a member of the terpene class of chemical compounds used in fragrances and flavorings, holds high promise as a biosynthetic alternative to D2 diesel fuel has generated keen interest in the green energy community and the trucking industry. Now a second team of researchers with the U.S Department of Energy (DOE)'s Joint BioEnergy Institute (JBEI) has determined
Biochemistry
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Wednesday, Jan 11, 2012, 10:30am
Rating: | Views: 1147 | Comments: 0
Tiny worm points to big promise
Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes.
Biochemistry
Source: Northwestern University
Posted on: Friday, Jan 06, 2012, 1:45pm
Rating: | Views: 1167 | Comments: 0
Research finds trigger for breast cancer spread
Research led by Shyamal Desai, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, has discovered a key change in the body's defense system that increases the potential for breast cancer to spread to other parts of the body. The results, reported for the first time, are featured in the January 2012 issue of Experimental Biology and Medicine.
Cancer
Source: Louisiana State University Health Sciences Center
Posted on: Tuesday, Jan 03, 2012, 4:15pm
Rating: | Views: 1216 | Comments: 0
Scientists pioneer new method for watching proteins fold
A protein's function depends on both the chains of molecules it is made of and the way those chains are folded. And while figuring out the former is relatively easy, the latter represents a huge challenge with serious implications because many diseases are the result of misfolded proteins. Now, a team of chemists at the University of Pennsylvania has devised a way to watch proteins
Biochemistry
Source: University of Pennsylvania
Posted on: Friday, Dec 23, 2011, 11:00am
Rating: | Views: 1338 | Comments: 0
Biochemists develop promising new treatment direction for rare metabolic diseases
A research team led by biochemist Scott Garman at the University of Massachusetts Amherst has discovered a key interaction at the heart of a promising new treatment for a rare childhood metabolic disorder known as Fabry disease. The discovery will help understanding of other protein-folding disorders such as Alzheimer's, Parkinson's and Huntington's diseases, as well. Findings are
Biochemistry
Source: University of Massachusetts at Amherst
Posted on: Thursday, Dec 22, 2011, 1:45pm
Rating: | Views: 1195 | Comments: 0
Discovery may lead to safer treatments for asthma, allergies and arthritis
Scientists have discovered a missing link between the body's biological clock and sugar metabolism system, a finding that may help avoid the serious side effects of drugs used for treating asthma, allergies and arthritis.
Biochemistry
Source: Salk Institute
Posted on: Tuesday, Dec 20, 2011, 11:15am
Rating: | Views: 1129 | Comments: 0
Bacterial protein 'mops up' viruses found in contaminated water supplies
Access to clean water is a necessity often taken for granted. However UNICEF estimates that 900 million people across the world do not have access to safe drinking water. New research published in BioMed Central's open access journal BMC Biotechnology shows that an enteric virus-binding protein (EVBP), isolated from bacteria found in activated sludge, is able to capture viruses often presen
Biochemistry
Source: BioMed Central
Posted on: Friday, Dec 16, 2011, 4:15pm
Rating: | Views: 1211 | Comments: 0
Decades-old conclusion about energy-making pathway of cyanobacteria is corrected
A generally accepted 44-year-old assumption about how certain kinds of bacteria make energy and synthesize cell materials has been shown to be incorrect by a team of scientists led by Donald Bryant, the Ernest C. Pollard Professor of Biotechnology at Penn State University and a research professor in the Department of Chemistry and Biochemistry at Montana State University.
Biochemistry
Source: Penn State
Posted on: Friday, Dec 16, 2011, 12:00pm
Rating: | Views: 1381 | Comments: 0
Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding
Something rotten never smelled so sweet. This is what Scientists are telling one another as they discuss a new finding they did not expect to make. They have discovered that hydrogen sulfide (H2S) – the flammable, highly toxic gas that we usually associate with the smell of rotten eggs – plays an important role in the regulation of a signaling pathway implicated in biologic malfunctions
Biochemistry
Source: Cold Spring Harbor Laboratory
Posted on: Tuesday, Dec 13, 2011, 4:15pm
Rating: | Views: 1254 | Comments: 0
Evolution reveals missing link between DNA and protein shape
Fifty years after the pioneering discovery that a protein's three-dimensional structure is determined solely by the sequence of its amino acids, an international team of researchers has taken a major step toward fulfilling the tantalizing promise: predicting the structure of a protein from its DNA alone.
Biochemistry
Source: Harvard Medical School
Posted on: Thursday, Dec 08, 2011, 11:45am
Rating: | Views: 1246 | Comments: 0
Supercomputer reveals new details behind drug-processing protein model
Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory are giving scientists unprecedented access to a key class of proteins involved in drug detoxification.
Biochemistry
Source: DOE/Oak Ridge National Laboratory
Posted on: Wednesday, Dec 07, 2011, 11:00am
Rating: | Views: 1372 | Comments: 0
Friends