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Researchers write protein nanoarrays using a fountain pen and electric fields 
Nanotechnology offers unique opportunities to advance the life sciences by facilitating the delivery, manipulation and observation of biological materials with unprecedented resolution. The ability to pattern nanoscale arrays of biological material assists studies of genomics, proteomics and cell adhesion, and may be applied to achieve increased sensitivity in drug screening and disease detection
Nanotechnology offers unique opportunities to advance the life sciences by facilitating the delivery, manipulation and observation of biological materials with unprecedented resolution. The ability to pattern nanoscale arrays of biological material assists studies of genomics, proteomics and cell adhesion, and may be applied to achieve increased sensitivity in drug screening and disease detection
Biochemistry
Source: Northwestern University
Posted on: Monday, Oct 13, 2008, 5:07pm
Rating: | Views: 1149 | Comments: 0
Source: Northwestern University
Posted on: Monday, Oct 13, 2008, 5:07pm
Rating: | Views: 1149 | Comments: 0
Body's anti-HIV drug explained
Humans have a built-in weapon against HIV, but until recently no one knew how to unlock its potential. A study published online by the journal Nature reveals the atomic structure of this weapon – an enzyme known as APOBEC-3G – and suggests new directions for drug development.
Humans have a built-in weapon against HIV, but until recently no one knew how to unlock its potential. A study published online by the journal Nature reveals the atomic structure of this weapon – an enzyme known as APOBEC-3G – and suggests new directions for drug development.
Biochemistry
Source: University of Southern California
Posted on: Monday, Oct 13, 2008, 8:12am
Rating: | Views: 1692 | Comments: 0
Source: University of Southern California
Posted on: Monday, Oct 13, 2008, 8:12am
Rating: | Views: 1692 | Comments: 0
Tracking down the cause of mad cow disease
The cause of diseases such as BSE in cattle and Creutzfeld–Jakob disease in humans is a prion protein. This protein attaches to cell membranes by way of an anchor made of sugar and lipid components (a glycosylphosphatidylinositol, GPI) anchor.
The cause of diseases such as BSE in cattle and Creutzfeld–Jakob disease in humans is a prion protein. This protein attaches to cell membranes by way of an anchor made of sugar and lipid components (a glycosylphosphatidylinositol, GPI) anchor.
Biochemistry
Source: Wiley-Blackwell
Posted on: Wednesday, Oct 08, 2008, 9:16am
Rating: | Views: 1233 | Comments: 0
Source: Wiley-Blackwell
Posted on: Wednesday, Oct 08, 2008, 9:16am
Rating: | Views: 1233 | Comments: 0
Atomic-resolution views suggest function of eye enzyme
An atomic-resolution view of an enzyme found only in the eye has given researchers at the University of Washington (UW) clues about how this enzyme, essential to vision, is activated. The enzyme, phosphodiesterase 6 (PDE6), is central to the way light entering the retina is converted into a cascade of signals to the brain.
An atomic-resolution view of an enzyme found only in the eye has given researchers at the University of Washington (UW) clues about how this enzyme, essential to vision, is activated. The enzyme, phosphodiesterase 6 (PDE6), is central to the way light entering the retina is converted into a cascade of signals to the brain.
Biochemistry
Source: University of Washington
Posted on: Tuesday, Oct 07, 2008, 10:30am
Rating: | Views: 1191 | Comments: 0
Source: University of Washington
Posted on: Tuesday, Oct 07, 2008, 10:30am
Rating: | Views: 1191 | Comments: 0
Bioengineers fill holes in science of cellular self-organization
The chemical and biological aspects of cellular self-organization are well-studied; less well understood is how cell populations order themselves biomechanically – how their behavior and communication are affected by high density and physical proximity.
The chemical and biological aspects of cellular self-organization are well-studied; less well understood is how cell populations order themselves biomechanically – how their behavior and communication are affected by high density and physical proximity.
Biochemistry
Source: University of California - San Diego
Posted on: Monday, Oct 06, 2008, 2:48pm
Rating: | Views: 1142 | Comments: 0
Source: University of California - San Diego
Posted on: Monday, Oct 06, 2008, 2:48pm
Rating: | Views: 1142 | Comments: 0
The structure of the Mre11 protein bound to DNA
Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for finding and signaling double-strand breaks (DSBs), then launching the error-free method of DNA repair called homologous recombination.
Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for finding and signaling double-strand breaks (DSBs), then launching the error-free method of DNA repair called homologous recombination.
Biochemistry
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Friday, Oct 03, 2008, 9:29am
Rating: | Views: 1236 | Comments: 0
Source: DOE/Lawrence Berkeley National Laboratory
Posted on: Friday, Oct 03, 2008, 9:29am
Rating: | Views: 1236 | Comments: 0
Scientists 'see' how HIV matures into an infection
After improving the sensitivity of nuclear magnetic resonance (NMR), researchers at the University of Missouri actually watched the HIV-1 protease mature from an inactive form into an active infection. This process has never been directly visualized before. The findings appear today in the journal Nature.
After improving the sensitivity of nuclear magnetic resonance (NMR), researchers at the University of Missouri actually watched the HIV-1 protease mature from an inactive form into an active infection. This process has never been directly visualized before. The findings appear today in the journal Nature.
Biochemistry
Source: University of Missouri-Columbia
Posted on: Wednesday, Oct 01, 2008, 1:06pm
Rating: | Views: 1382 | Comments: 0
Source: University of Missouri-Columbia
Posted on: Wednesday, Oct 01, 2008, 1:06pm
Rating: | Views: 1382 | Comments: 0
Scientists peer into heart of compound that may detect chemical, biological weapons
A light-transmitting compound that could one day be used in high-efficiency fiber optics and in sensors to detect biological and chemical weapons at long distance almost went undiscovered by scientists because its structure was too difficult to examine.
A light-transmitting compound that could one day be used in high-efficiency fiber optics and in sensors to detect biological and chemical weapons at long distance almost went undiscovered by scientists because its structure was too difficult to examine.
Biochemistry
Source: DOE/Argonne National Laboratory
Posted on: Friday, Sep 26, 2008, 11:27am
Rating: | Views: 1802 | Comments: 0
Source: DOE/Argonne National Laboratory
Posted on: Friday, Sep 26, 2008, 11:27am
Rating: | Views: 1802 | Comments: 0
Biophysicists create new model for protein-cholesterol interactions
Biophysicists at the University of Pennsylvania have used 3,200 computer processors and long-established data on cholesterol's role in the function of proteins to clarify the mysterious interaction between cholesterol and neurotransmitter receptors. The results provide a new model of behavior for the nicotinic acetylcholine receptor, a well studied protein involved in inflammation and disease
Biophysicists at the University of Pennsylvania have used 3,200 computer processors and long-established data on cholesterol's role in the function of proteins to clarify the mysterious interaction between cholesterol and neurotransmitter receptors. The results provide a new model of behavior for the nicotinic acetylcholine receptor, a well studied protein involved in inflammation and disease
Biochemistry
Source: University of Pennsylvania
Posted on: Friday, Sep 26, 2008, 10:52am
Rating: | Views: 1180 | Comments: 0
Source: University of Pennsylvania
Posted on: Friday, Sep 26, 2008, 10:52am
Rating: | Views: 1180 | Comments: 0
New technology paves the way for the future of identifying proteins inside cells
A new technology which enables scientists to identify proteins by making a map of the energy flow inside the protein is revealed today in Proceedings of the National Academy of Sciences (PNAS) journal.
A new technology which enables scientists to identify proteins by making a map of the energy flow inside the protein is revealed today in Proceedings of the National Academy of Sciences (PNAS) journal.
Biochemistry
Source: Imperial College London
Posted on: Tuesday, Sep 23, 2008, 9:05am
Rating: | Views: 1122 | Comments: 0
Source: Imperial College London
Posted on: Tuesday, Sep 23, 2008, 9:05am
Rating: | Views: 1122 | Comments: 0
Key proteins identified in the quest for male contraceptive
In an advance toward a long-sought new male contraceptive, researchers in China have identified key proteins in men that suppress production of sperm and could become new targets for a future male birth control pill. Their study is scheduled for the October 3 issue of ACS' monthly Journal of Proteome Research.
In an advance toward a long-sought new male contraceptive, researchers in China have identified key proteins in men that suppress production of sperm and could become new targets for a future male birth control pill. Their study is scheduled for the October 3 issue of ACS' monthly Journal of Proteome Research.
Biochemistry
Source: American Chemical Society
Posted on: Monday, Sep 22, 2008, 9:49am
Rating: | Views: 1144 | Comments: 0
Source: American Chemical Society
Posted on: Monday, Sep 22, 2008, 9:49am
Rating: | Views: 1144 | Comments: 0
study gives new insights into how cells accessorize their proteins
St. Jude Children's Research Hospital investigators have gained new insight into how the cell's vast array of proteins would instantly be reduced to a confusion of lethally malfunctioning molecules without a system for proteins to "accessorize" in order to regulate their function.
St. Jude Children's Research Hospital investigators have gained new insight into how the cell's vast array of proteins would instantly be reduced to a confusion of lethally malfunctioning molecules without a system for proteins to "accessorize" in order to regulate their function.
Biochemistry
Source: St. Jude Children's Research Hospital
Posted on: Thursday, Sep 18, 2008, 2:16pm
Rating: | Views: 1140 | Comments: 0
Source: St. Jude Children's Research Hospital
Posted on: Thursday, Sep 18, 2008, 2:16pm
Rating: | Views: 1140 | Comments: 0
Determining the structure of nuclear receptor has implications for a host of diseases
In a study published this week in PLoS Biology, Eric Xu and colleagues have determined the molecular structure of a nuclear receptor, which regulates the expression of specific genes within cells, that may serve as a drug target for diseases related to heart and blood vessel development, human embryonic development and female infertility.
In a study published this week in PLoS Biology, Eric Xu and colleagues have determined the molecular structure of a nuclear receptor, which regulates the expression of specific genes within cells, that may serve as a drug target for diseases related to heart and blood vessel development, human embryonic development and female infertility.
Biochemistry
Source: Public Library of Science
Posted on: Tuesday, Sep 16, 2008, 8:49am
Rating: | Views: 1163 | Comments: 0
Source: Public Library of Science
Posted on: Tuesday, Sep 16, 2008, 8:49am
Rating: | Views: 1163 | Comments: 0
Enzyme detectives uncover new reactions
If your experiment doesn't go the way you expect, take a closer look -- something even more interesting may have happened. That strategy has led scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory to discover a fundamental shift in an enzyme's function that could help expand the toolbox for engineering biofuels and other plant-based oil products.
If your experiment doesn't go the way you expect, take a closer look -- something even more interesting may have happened. That strategy has led scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory to discover a fundamental shift in an enzyme's function that could help expand the toolbox for engineering biofuels and other plant-based oil products.
Biochemistry
Source: DOE/Brookhaven National Laboratory
Posted on: Monday, Sep 08, 2008, 5:23pm
Rating: | Views: 1214 | Comments: 0
Source: DOE/Brookhaven National Laboratory
Posted on: Monday, Sep 08, 2008, 5:23pm
Rating: | Views: 1214 | Comments: 0
Atomic structure of the mammalian 'fatty acid factory' determined
Mammalian fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. Now researchers at ETH Zurich have determined the atomic structure of a mammalian fatty acid synthase.
Mammalian fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. Now researchers at ETH Zurich have determined the atomic structure of a mammalian fatty acid synthase.
Biochemistry
Source: ETH Zurich/Swiss Federal Institute of Technology
Posted on: Friday, Sep 05, 2008, 9:31am
Rating: | Views: 1424 | Comments: 0
Source: ETH Zurich/Swiss Federal Institute of Technology
Posted on: Friday, Sep 05, 2008, 9:31am
Rating: | Views: 1424 | Comments: 0
Fatal protein interactions may explain neurological diseases
In a collaborative study at the University of California, San Diego, investigators from neurosciences, chemistry and medicine, as well as the San Diego Supercomputer Center (SDSC) have investigated how proteins involved in neurodegenerative diseases such as Alzheimer's and Parkinson's disease interact to form unique complexes.
In a collaborative study at the University of California, San Diego, investigators from neurosciences, chemistry and medicine, as well as the San Diego Supercomputer Center (SDSC) have investigated how proteins involved in neurodegenerative diseases such as Alzheimer's and Parkinson's disease interact to form unique complexes.
Biochemistry
Source: University of California - San Diego
Posted on: Thursday, Sep 04, 2008, 8:32am
Rating: | Views: 1146 | Comments: 0
Source: University of California - San Diego
Posted on: Thursday, Sep 04, 2008, 8:32am
Rating: | Views: 1146 | Comments: 0
DNA editing tool flips its target
Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation.
Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation.
Biochemistry
Source: Emory University
Posted on: Wednesday, Sep 03, 2008, 2:21pm
Rating: | Views: 1153 | Comments: 0
Source: Emory University
Posted on: Wednesday, Sep 03, 2008, 2:21pm
Rating: | Views: 1153 | Comments: 0
Scientists develop new method to investigate origin of life
Scientists at Penn State have developed a new computational method that they say will help them to understand how life began on Earth.
Scientists at Penn State have developed a new computational method that they say will help them to understand how life began on Earth.
Biochemistry
Source: Penn State
Posted on: Tuesday, Sep 02, 2008, 8:23am
Rating: | Views: 1125 | Comments: 0
Source: Penn State
Posted on: Tuesday, Sep 02, 2008, 8:23am
Rating: | Views: 1125 | Comments: 0
Discovery opens door for drugs to fight bird flu, other influenza epidemics
Researchers at Rutgers University and The University of Texas at Austin have reported a discovery that could help scientists develop drugs to fight the much-feared bird flu and other virulent strains of influenza.
Researchers at Rutgers University and The University of Texas at Austin have reported a discovery that could help scientists develop drugs to fight the much-feared bird flu and other virulent strains of influenza.
Biochemistry
Source: University of Texas at Austin\Rutgers
Posted on: Monday, Aug 25, 2008, 11:11am
Rating: | Views: 1171 | Comments: 0
Source: University of Texas at Austin\Rutgers
Posted on: Monday, Aug 25, 2008, 11:11am
Rating: | Views: 1171 | Comments: 0
Fresh doubts over T. rex chicken link
Critics call on researchers to disclose protein spectra data.
Critics call on researchers to disclose protein spectra data.
Biochemistry
Source: Nature
Posted on: Friday, Aug 22, 2008, 9:19am
Rating: | Views: 1276 | Comments: 0
Source: Nature
Posted on: Friday, Aug 22, 2008, 9:19am
Rating: | Views: 1276 | Comments: 0
MIT zeroes in on Alzheimer's structures
MIT engineers report a new approach to identifying protein structures key to Alzheimer's disease, an important step toward the development of new drugs that could prevent such structures from forming.
MIT engineers report a new approach to identifying protein structures key to Alzheimer's disease, an important step toward the development of new drugs that could prevent such structures from forming.
Biochemistry
Source: Massachusetts Institute of Technology
Posted on: Friday, Aug 22, 2008, 9:19am
Rating: | Views: 3822 | Comments: 0
Source: Massachusetts Institute of Technology
Posted on: Friday, Aug 22, 2008, 9:19am
Rating: | Views: 3822 | Comments: 0
Biochemists manipulate fruit flavor enzymes
Would you like a lemony watermelon? How about a strawberry-flavored banana? Biochemists at The University of Texas Medical School at Houston say the day may be coming when scientists will be able to fine tune enzymes responsible for flavors in fruits and vegetables. In addition, it could lead to environmentally-friendly pest control.
Would you like a lemony watermelon? How about a strawberry-flavored banana? Biochemists at The University of Texas Medical School at Houston say the day may be coming when scientists will be able to fine tune enzymes responsible for flavors in fruits and vegetables. In addition, it could lead to environmentally-friendly pest control.
Biochemistry
Source: University of Texas Health Science Center at Houston
Posted on: Wednesday, Aug 20, 2008, 4:30pm
Rating: | Views: 1270 | Comments: 0
Source: University of Texas Health Science Center at Houston
Posted on: Wednesday, Aug 20, 2008, 4:30pm
Rating: | Views: 1270 | Comments: 0
Lab finds molecular clues to Wilson disease
Using a combination of computer simulations and cutting-edge lab experiments, physical biochemists at Rice University have discovered how a small genetic mutation -- which is known to cause Wilson disease -- subtly changes the structure of a large, complex protein that the body uses to keep copper from building up to toxic levels.
Using a combination of computer simulations and cutting-edge lab experiments, physical biochemists at Rice University have discovered how a small genetic mutation -- which is known to cause Wilson disease -- subtly changes the structure of a large, complex protein that the body uses to keep copper from building up to toxic levels.
Biochemistry
Source: Rice University
Posted on: Tuesday, Aug 19, 2008, 10:43am
Rating: | Views: 1220 | Comments: 0
Source: Rice University
Posted on: Tuesday, Aug 19, 2008, 10:43am
Rating: | Views: 1220 | Comments: 0
Chemists move closer toward developing safer, fully-synthetic form of heparin
Chemists are reporting a major advance toward developing a safer, fully-synthetic version of heparin, the widely used blood thinner now produced from pig intestines.
Chemists are reporting a major advance toward developing a safer, fully-synthetic version of heparin, the widely used blood thinner now produced from pig intestines.
Biochemistry
Source: American Chemical Society
Posted on: Monday, Aug 18, 2008, 9:15am
Rating: | Views: 1166 | Comments: 0
Source: American Chemical Society
Posted on: Monday, Aug 18, 2008, 9:15am
Rating: | Views: 1166 | Comments: 0
"Snow flea antifreeze protein" could help improve organ preservation
Scientists in Illinois and Pennsylvania are reporting development of a way to make the antifreeze protein that enables billions of Canadian snow fleas to survive frigid winter temperatures.
Scientists in Illinois and Pennsylvania are reporting development of a way to make the antifreeze protein that enables billions of Canadian snow fleas to survive frigid winter temperatures.
Biochemistry
Source: American Chemical Society
Posted on: Monday, Jul 21, 2008, 10:10am
Rating: | Views: 1327 | Comments: 0
Source: American Chemical Society
Posted on: Monday, Jul 21, 2008, 10:10am
Rating: | Views: 1327 | Comments: 0
Newly described 'dragon' protein could be key to bird flu cure
Scientists and researchers have taken a big step closer to a cure for the most common strain of avian influenza, or "bird flu," the potential pandemic that has claimed more than 200 lives and infected nearly 400 people in 14 countries since it was identified in 2003.
Scientists and researchers have taken a big step closer to a cure for the most common strain of avian influenza, or "bird flu," the potential pandemic that has claimed more than 200 lives and infected nearly 400 people in 14 countries since it was identified in 2003.
Biochemistry
Source: DOE/Argonne National Laboratory
Posted on: Tuesday, Jul 15, 2008, 2:10pm
Rating: | Views: 1272 | Comments: 0
Source: DOE/Argonne National Laboratory
Posted on: Tuesday, Jul 15, 2008, 2:10pm
Rating: | Views: 1272 | Comments: 0
Detecting flu viruses in remote areas of the world
Researchers in Ohio and New Mexico are reporting an advance in the quest for a fast, sensitive test to detect flu viruses — one that requires no refrigeration and can be used in remote areas of the world where new flu viruses often emerge.
Researchers in Ohio and New Mexico are reporting an advance in the quest for a fast, sensitive test to detect flu viruses — one that requires no refrigeration and can be used in remote areas of the world where new flu viruses often emerge.
Biochemistry
Source: American Chemical Society
Posted on: Monday, Jul 14, 2008, 9:17am
Rating: | Views: 1314 | Comments: 0
Source: American Chemical Society
Posted on: Monday, Jul 14, 2008, 9:17am
Rating: | Views: 1314 | Comments: 0
Researchers catch ion channels in their opening act
Each thought or action sends a million electrical signals pulsing through your body. At the heart of the process of generating these electrical impulses is the ion channel.
Each thought or action sends a million electrical signals pulsing through your body. At the heart of the process of generating these electrical impulses is the ion channel.
Biochemistry
Source: University of Illinois at Urbana-Champaign
Posted on: Thursday, Jul 10, 2008, 2:06pm
Rating: | Views: 1196 | Comments: 0
Source: University of Illinois at Urbana-Champaign
Posted on: Thursday, Jul 10, 2008, 2:06pm
Rating: | Views: 1196 | Comments: 0
Researchers unveil near-complete protein catalog for mitochondria
Imagine trying to figure out how your car's power train works from just a few of its myriad components: It would be nearly impossible. Scientists have long faced a similar challenge in understanding cells' tiny powerhouses — called "mitochondria" — from scant knowledge of their molecular parts.
Imagine trying to figure out how your car's power train works from just a few of its myriad components: It would be nearly impossible. Scientists have long faced a similar challenge in understanding cells' tiny powerhouses — called "mitochondria" — from scant knowledge of their molecular parts.
Biochemistry
Source: Broad Institute of MIT and Harvard
Posted on: Thursday, Jul 10, 2008, 12:52pm
Rating: | Views: 1316 | Comments: 0
Source: Broad Institute of MIT and Harvard
Posted on: Thursday, Jul 10, 2008, 12:52pm
Rating: | Views: 1316 | Comments: 0
Research scientists reveal key structure from ebola virus
Described in the July 10, 2008 issue of the journal Nature, the research reveals the shape of the Ebola virus spike protein, which is necessary for viral entry into human cells, bound to an immune system antibody acting to neutralize the virus.
Described in the July 10, 2008 issue of the journal Nature, the research reveals the shape of the Ebola virus spike protein, which is necessary for viral entry into human cells, bound to an immune system antibody acting to neutralize the virus.
Biochemistry
Source: Scripps Research Institute
Posted on: Wednesday, Jul 09, 2008, 3:09pm
Rating: | Views: 1830 | Comments: 0
Source: Scripps Research Institute
Posted on: Wednesday, Jul 09, 2008, 3:09pm
Rating: | Views: 1830 | Comments: 0
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