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A little pressure in proteomics squeezes 4-hour step into a minute 
Many coaches inspire better performance by pressuring their teams. Now, proteomics researchers are using pressure to improve the performance of their analyses. In a simple solution to a time-consuming problem, the researchers have found that adding pressure early in their protocol squeezes four hours of waiting into a minute.
Many coaches inspire better performance by pressuring their teams. Now, proteomics researchers are using pressure to improve the performance of their analyses. In a simple solution to a time-consuming problem, the researchers have found that adding pressure early in their protocol squeezes four hours of waiting into a minute.
Biochemistry
Source: DOE/Pacific Northwest National Laboratory
Posted on: Wednesday, Jul 09, 2008, 1:33pm
Rating: | Views: 1216 | Comments: 0
Source: DOE/Pacific Northwest National Laboratory
Posted on: Wednesday, Jul 09, 2008, 1:33pm
Rating: | Views: 1216 | Comments: 0
Synthetic molecules emulate enzyme behavior for the first time
When chemists want to produce a lot of a substance -- such as a newly designed drug -- they often turn to catalysts, molecules that speed chemical reactions. Many jobs require highly specialized catalysts, and finding one in just the right shape to connect with certain molecules can be difficult.
When chemists want to produce a lot of a substance -- such as a newly designed drug -- they often turn to catalysts, molecules that speed chemical reactions. Many jobs require highly specialized catalysts, and finding one in just the right shape to connect with certain molecules can be difficult.
Biochemistry
Source: Ohio State University
Posted on: Wednesday, Jul 02, 2008, 10:48am
Rating: | Views: 1206 | Comments: 0
Source: Ohio State University
Posted on: Wednesday, Jul 02, 2008, 10:48am
Rating: | Views: 1206 | Comments: 0
Small protein may have big role in making more bone and less fat
A small protein may have a big role in helping you make more bone and less fat, researchers say.
A small protein may have a big role in helping you make more bone and less fat, researchers say.
Biochemistry
Source: Medical College of Georgia
Posted on: Tuesday, Jul 01, 2008, 4:43pm
Rating: | Views: 1208 | Comments: 0
Source: Medical College of Georgia
Posted on: Tuesday, Jul 01, 2008, 4:43pm
Rating: | Views: 1208 | Comments: 0
A mammalian clock protein responds directly to light
We all know that light effects the growth and development of plants, but what effect does light have on humans and animals? A new paper by Nathalie Hoang et al., published in PLoS Biology this week, explores this question by examining cryptochromes in flies, mice, and humans.
We all know that light effects the growth and development of plants, but what effect does light have on humans and animals? A new paper by Nathalie Hoang et al., published in PLoS Biology this week, explores this question by examining cryptochromes in flies, mice, and humans.
Biochemistry
Source: Public Library of Science
Posted on: Tuesday, Jul 01, 2008, 8:46am
Rating: | Views: 1293 | Comments: 0
Source: Public Library of Science
Posted on: Tuesday, Jul 01, 2008, 8:46am
Rating: | Views: 1293 | Comments: 0
Researchers use supercomputer to track pathways in myoglobin
Some 50 years ago, after decades of effort, John Kendrew determined the structure of the small globular protein, myoglobin, which is responsible for oxygen storage in cells. For this discovery, he shared the Nobel Prize in chemistry with Max Perutz, who did similar work on hemoglobin. But a mystery remained: Exactly what paths does oxygen follow as it moves in and out of myoglobin?
Some 50 years ago, after decades of effort, John Kendrew determined the structure of the small globular protein, myoglobin, which is responsible for oxygen storage in cells. For this discovery, he shared the Nobel Prize in chemistry with Max Perutz, who did similar work on hemoglobin. But a mystery remained: Exactly what paths does oxygen follow as it moves in and out of myoglobin?
Biochemistry
Source: Virginia Tech
Posted on: Monday, Jun 30, 2008, 5:13pm
Rating: | Views: 1193 | Comments: 0
Source: Virginia Tech
Posted on: Monday, Jun 30, 2008, 5:13pm
Rating: | Views: 1193 | Comments: 0
Shape shifting protein may be a bacteria fighter
A small molecule that locks an essential enzyme in an inactive form could one day form the basis of a new class of unbeatable, species-specific antibiotics, according to researchers at Fox Chase Cancer Center.
A small molecule that locks an essential enzyme in an inactive form could one day form the basis of a new class of unbeatable, species-specific antibiotics, according to researchers at Fox Chase Cancer Center.
Biochemistry
Source: Fox Chase Cancer Center
Posted on: Friday, Jun 20, 2008, 12:00pm
Rating: | Views: 1269 | Comments: 0
Source: Fox Chase Cancer Center
Posted on: Friday, Jun 20, 2008, 12:00pm
Rating: | Views: 1269 | Comments: 0
Scientists discover DNA knot keeps viral genes tightly corked inside shell
A novel twist of DNA may keep viral genes tightly wound within a capsule, waiting for ejection into a host, a high-resolution analysis of its structure has revealed.
A novel twist of DNA may keep viral genes tightly wound within a capsule, waiting for ejection into a host, a high-resolution analysis of its structure has revealed.
Biochemistry
Source: University of California - San Diego
Posted on: Tuesday, Jun 17, 2008, 6:42pm
Rating: | Views: 1194 | Comments: 0
Source: University of California - San Diego
Posted on: Tuesday, Jun 17, 2008, 6:42pm
Rating: | Views: 1194 | Comments: 0
Researchers witness assembly of molecules critical to protein function
A Virginia Tech research group lead by two biochemistry graduate students has isolated proteins responsible for the iron-sulfur cluster assembly process and witnessed the necessary protein interactions in vivo – within a cell.
A Virginia Tech research group lead by two biochemistry graduate students has isolated proteins responsible for the iron-sulfur cluster assembly process and witnessed the necessary protein interactions in vivo – within a cell.
Biochemistry
Source: Virginia Tech
Posted on: Tuesday, Jun 17, 2008, 8:57am
Rating: | Views: 1209 | Comments: 0
Source: Virginia Tech
Posted on: Tuesday, Jun 17, 2008, 8:57am
Rating: | Views: 1209 | Comments: 0
Membrane complexes take flight
Against currently held dogma, scientists at the Universities of Cambridge and Bristol have revealed that the interactions within membrane complexes can be maintained intact in the vacuum of a mass spectrometer. Their research is published in this week's edition of Science Express.
Against currently held dogma, scientists at the Universities of Cambridge and Bristol have revealed that the interactions within membrane complexes can be maintained intact in the vacuum of a mass spectrometer. Their research is published in this week's edition of Science Express.
Biochemistry
Source: University of Cambridge
Posted on: Thursday, Jun 12, 2008, 1:48pm
Rating: | Views: 1306 | Comments: 0
Source: University of Cambridge
Posted on: Thursday, Jun 12, 2008, 1:48pm
Rating: | Views: 1306 | Comments: 0
Researchers reveal insights into hidden world of protein folding
The proteins upon which life depends share an attribute with paper airplanes: Unless folded properly, they just won't fly.
The proteins upon which life depends share an attribute with paper airplanes: Unless folded properly, they just won't fly.
Biochemistry
Source: Stanford University
Posted on: Wednesday, Jun 11, 2008, 3:20pm
Rating: | Views: 1233 | Comments: 0
Source: Stanford University
Posted on: Wednesday, Jun 11, 2008, 3:20pm
Rating: | Views: 1233 | Comments: 0
New drug to stop tuberculosis epidemic
Researchers at the University of Manchester are developing a new drug against tuberculosis (TB), one of the oldest human infectious diseases, which is now threatening to reach epidemic proportions once more.
Researchers at the University of Manchester are developing a new drug against tuberculosis (TB), one of the oldest human infectious diseases, which is now threatening to reach epidemic proportions once more.
Biochemistry
Source: University of Manchester
Posted on: Friday, Jun 06, 2008, 11:19am
Rating: | Views: 1252 | Comments: 0
Source: University of Manchester
Posted on: Friday, Jun 06, 2008, 11:19am
Rating: | Views: 1252 | Comments: 0
Protein found to promote antibiotic resistance in a common food-borne pathogen
Researchers from Iowa State University have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen. The study, published June 6th in the open-access journal PLoS Pathogens, explains that Mfd, a protein involved in DNA transcription and repair, plays an important role in the development of fluoroquinolone resistance in Campylobacter
Researchers from Iowa State University have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen. The study, published June 6th in the open-access journal PLoS Pathogens, explains that Mfd, a protein involved in DNA transcription and repair, plays an important role in the development of fluoroquinolone resistance in Campylobacter
Biochemistry
Source: PLoS
Posted on: Friday, Jun 06, 2008, 10:09am
Rating: | Views: 1233 | Comments: 0
Source: PLoS
Posted on: Friday, Jun 06, 2008, 10:09am
Rating: | Views: 1233 | Comments: 0
Researchers observe spontaneous 'ratcheting' of single ribosome molecules
Researchers report this week that they are the first to observe the dynamic, ratchet-like movements of single ribosomal molecules in the act of building proteins from genetic blueprints.
Researchers report this week that they are the first to observe the dynamic, ratchet-like movements of single ribosomal molecules in the act of building proteins from genetic blueprints.
Biochemistry
Source: University of Illinois at Urbana-Champaign
Posted on: Thursday, Jun 05, 2008, 6:41pm
Rating: | Views: 1201 | Comments: 0
Source: University of Illinois at Urbana-Champaign
Posted on: Thursday, Jun 05, 2008, 6:41pm
Rating: | Views: 1201 | Comments: 0
Talking to cells
For an organism to develop and function, the individual cells must exchange information, or communicate, with each other. Is it possible to learn their language and "talk to" the cells?
For an organism to develop and function, the individual cells must exchange information, or communicate, with each other. Is it possible to learn their language and "talk to" the cells?
Biochemistry
Source: Wiley-Blackwell
Posted on: Thursday, Jun 05, 2008, 10:09am
Rating: | Views: 1274 | Comments: 0
Source: Wiley-Blackwell
Posted on: Thursday, Jun 05, 2008, 10:09am
Rating: | Views: 1274 | Comments: 0
Simple membranes could have allowed nutrients to pass into primitive cells
When the first cells developed, how could they bring molecules from the environment into their living interior without the specialized structures found on the modern cell membrane?
When the first cells developed, how could they bring molecules from the environment into their living interior without the specialized structures found on the modern cell membrane?
Biochemistry
Source: Massachusetts General Hospital
Posted on: Wednesday, Jun 04, 2008, 12:38pm
Rating: | Views: 1325 | Comments: 0
Source: Massachusetts General Hospital
Posted on: Wednesday, Jun 04, 2008, 12:38pm
Rating: | Views: 1325 | Comments: 0
Self-assembled viruses
Viruses are true experts at importing genetic material into the cells of an infected organism. This trait is now being exploited for gene therapy, in which genes are brought into the cells of a patient to treat genetic diseases or genetic defects. Korean researchers have now made an artificial virus.
Viruses are true experts at importing genetic material into the cells of an infected organism. This trait is now being exploited for gene therapy, in which genes are brought into the cells of a patient to treat genetic diseases or genetic defects. Korean researchers have now made an artificial virus.
Biochemistry
Source: EurekAlert
Posted on: Friday, May 30, 2008, 10:51am
Rating: | Views: 1292 | Comments: 0
Source: EurekAlert
Posted on: Friday, May 30, 2008, 10:51am
Rating: | Views: 1292 | Comments: 0
A molecular switch turns on the flame in 'nature's blowtorch'
Uncontrolled reaction of organic compounds with oxygen is easy: we call it fire. But nature often needs to do oxidations very specifically, adding oxygen to a particular carbon atom in a complicated molecule without disturbing anything else.
Uncontrolled reaction of organic compounds with oxygen is easy: we call it fire. But nature often needs to do oxidations very specifically, adding oxygen to a particular carbon atom in a complicated molecule without disturbing anything else.
Biochemistry
Source: EurekAlert
Posted on: Friday, May 30, 2008, 10:02am
Rating: | Views: 1240 | Comments: 0
Source: EurekAlert
Posted on: Friday, May 30, 2008, 10:02am
Rating: | Views: 1240 | Comments: 0
The structure of XPD sheds light on cancer and aging
The protein XPD is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum, extreme sensitivity to sunlight promotes cancer; Cockayne syndrome involves stunted growth and premature aging
The protein XPD is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum, extreme sensitivity to sunlight promotes cancer; Cockayne syndrome involves stunted growth and premature aging
Biochemistry
Source: EurekAlert
Posted on: Thursday, May 29, 2008, 11:31am
Rating: | Views: 1241 | Comments: 0
Source: EurekAlert
Posted on: Thursday, May 29, 2008, 11:31am
Rating: | Views: 1241 | Comments: 0
Molecular Snapshot of a Virulence Factor on Bacterial Surface
David G. Thanassi, Ph.D., of Stony Brook University, and colleagues are the first to capture a view of proteins during translocation across the bacterial outer membrane. This “molecular snapshot” may enlighten scientists to the protein secretion process across membranes and provide a foundation to understanding certain bacterial virulence factors that allow bacteria to cause disease.
David G. Thanassi, Ph.D., of Stony Brook University, and colleagues are the first to capture a view of proteins during translocation across the bacterial outer membrane. This “molecular snapshot” may enlighten scientists to the protein secretion process across membranes and provide a foundation to understanding certain bacterial virulence factors that allow bacteria to cause disease.
Biochemistry
Source: Newswise
Posted on: Thursday, May 29, 2008, 10:38am
Rating: | Views: 1283 | Comments: 0
Source: Newswise
Posted on: Thursday, May 29, 2008, 10:38am
Rating: | Views: 1283 | Comments: 0
Fruit fly helps identify protein critical to eggshell formation
The common fruit fly circling your week-old peach has helped scientists zero in on a protein critical to the insect's eggshell formation.
The common fruit fly circling your week-old peach has helped scientists zero in on a protein critical to the insect's eggshell formation.
Biochemistry
Source: EurekAlert
Posted on: Thursday, May 29, 2008, 10:14am
Rating: | Views: 1234 | Comments: 0
Source: EurekAlert
Posted on: Thursday, May 29, 2008, 10:14am
Rating: | Views: 1234 | Comments: 0
Fruit fly protein acts as decoy to capture tumor growth factors
Researchers at the University of Pennsylvania School of Medicine have shown how Argos, a fruit fly protein, acts as a ¡¥decoy' receptor, binding growth factors that promote the progression of cancer. Knowing how Argos neutralizes tumor growth may lead to new drug designs for inhibiting cancer. The study appeared online in Nature in advance of print publication.
Researchers at the University of Pennsylvania School of Medicine have shown how Argos, a fruit fly protein, acts as a ¡¥decoy' receptor, binding growth factors that promote the progression of cancer. Knowing how Argos neutralizes tumor growth may lead to new drug designs for inhibiting cancer. The study appeared online in Nature in advance of print publication.
Biochemistry
Source: EurekAlert
Posted on: Wednesday, May 28, 2008, 3:21pm
Rating: | Views: 1232 | Comments: 0
Source: EurekAlert
Posted on: Wednesday, May 28, 2008, 3:21pm
Rating: | Views: 1232 | Comments: 0
The secret behind silkworm's hardy stomachs
Silkworms have a unique ability to eat toxic mulberry leaves without feeling ill, and researchers have come one step closer to understanding why: silkworms contain a special digestive enzyme that is not affected by mulberry’s toxic chemicals.
Silkworms have a unique ability to eat toxic mulberry leaves without feeling ill, and researchers have come one step closer to understanding why: silkworms contain a special digestive enzyme that is not affected by mulberry’s toxic chemicals.
Biochemistry
Source: EurekAlert
Posted on: Tuesday, May 27, 2008, 3:46pm
Rating: | Views: 1206 | Comments: 0
Source: EurekAlert
Posted on: Tuesday, May 27, 2008, 3:46pm
Rating: | Views: 1206 | Comments: 0
Chemists create cancer-detecting nanoparticles
Magnetic resonance imaging (MRI) can be a doctor's best friend for detecting a tumor in the body without resorting to surgery. MRI scans use pulses of magnetic waves and gauge the return signals to identify different types of tissue in the body, distinguishing bone from muscle, fluids from solids, and so on.
Magnetic resonance imaging (MRI) can be a doctor's best friend for detecting a tumor in the body without resorting to surgery. MRI scans use pulses of magnetic waves and gauge the return signals to identify different types of tissue in the body, distinguishing bone from muscle, fluids from solids, and so on.
Biochemistry
Source: EurekAlert
Posted on: Tuesday, May 27, 2008, 11:17am
Rating: | Views: 1217 | Comments: 0
Source: EurekAlert
Posted on: Tuesday, May 27, 2008, 11:17am
Rating: | Views: 1217 | Comments: 0
Some like it hot! Structure of receptor for hot chili pepper and pain revealed
You can now not only feel the spicy kick of a jalapeno pepper, you can also see it in full 3D, thanks to researchers at Baylor College of Medicine in Houston.
You can now not only feel the spicy kick of a jalapeno pepper, you can also see it in full 3D, thanks to researchers at Baylor College of Medicine in Houston.
Biochemistry
Source: EurekAlert
Posted on: Monday, May 19, 2008, 5:29pm
Rating: | Views: 1421 | Comments: 0
Source: EurekAlert
Posted on: Monday, May 19, 2008, 5:29pm
Rating: | Views: 1421 | Comments: 0
Researchers automate analysis of protein patterns
Carnegie Mellon University’s Justin Y. Newberg and Robert F. Murphy have developed a software toolbox that is intended to help bioscience researchers characterize protein patterns in human tissues.
Carnegie Mellon University’s Justin Y. Newberg and Robert F. Murphy have developed a software toolbox that is intended to help bioscience researchers characterize protein patterns in human tissues.
Biochemistry
Source: EurekAlert
Posted on: Monday, May 12, 2008, 5:57pm
Rating: | Views: 1193 | Comments: 0
Source: EurekAlert
Posted on: Monday, May 12, 2008, 5:57pm
Rating: | Views: 1193 | Comments: 0
New clues to how proteins dissolve and crystallize
In the late 19th century the Czech scientist Franz Hofmeister observed that some salts (ionic compounds) aided the solution of proteins in egg white, some caused the proteins to destabilize and precipitate, and others ranged in activity between these poles.
In the late 19th century the Czech scientist Franz Hofmeister observed that some salts (ionic compounds) aided the solution of proteins in egg white, some caused the proteins to destabilize and precipitate, and others ranged in activity between these poles.
Biochemistry
Source: EurekAlert
Posted on: Monday, May 12, 2008, 12:29pm
Rating: | Views: 1188 | Comments: 0
Source: EurekAlert
Posted on: Monday, May 12, 2008, 12:29pm
Rating: | Views: 1188 | Comments: 0
Model shows how mutation tips biochemistry to cause Alzheimer's
Your fate can be determined by tiny events. Imagine you live in the city and you walk everywhere to get exercise – you are healthy and not afraid of getting mugged. You almost never eat breakfast so you don’t stop at the donut shop on the way to work, until one day the manager replaces the girl at the counter with her pretty red-haired younger sister.
Your fate can be determined by tiny events. Imagine you live in the city and you walk everywhere to get exercise – you are healthy and not afraid of getting mugged. You almost never eat breakfast so you don’t stop at the donut shop on the way to work, until one day the manager replaces the girl at the counter with her pretty red-haired younger sister.
Biochemistry
Source: EurekAlert
Posted on: Monday, May 12, 2008, 8:33am
Rating: | Views: 1191 | Comments: 0
Source: EurekAlert
Posted on: Monday, May 12, 2008, 8:33am
Rating: | Views: 1191 | Comments: 0
A step forward in virology
The vaccinia virus has a problem: it is a giant among viruses and needs a special strategy in order to infiltrate a cell and reproduce. Professor Ari Helenius and Postdoc Jason Mercer from ETH Zurich’s Institute for Biochemistry have now discovered what this strategy is. In the process, they stumbled upon new and surprising findings.
The vaccinia virus has a problem: it is a giant among viruses and needs a special strategy in order to infiltrate a cell and reproduce. Professor Ari Helenius and Postdoc Jason Mercer from ETH Zurich’s Institute for Biochemistry have now discovered what this strategy is. In the process, they stumbled upon new and surprising findings.
Immunology
Source: EurekAlert
Posted on: Friday, Apr 25, 2008, 9:12am
Rating: | Views: 1390 | Comments: 0
Source: EurekAlert
Posted on: Friday, Apr 25, 2008, 9:12am
Rating: | Views: 1390 | Comments: 0
Protein data bank archives 50,000th molecule structure
The Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, and the University of California-San Diego (UCSD) this month reached a significant milestone in its 37-year history. The 50,000th molecule structure was released into its archive, joining other structures vital to pharmacology, bioinformatics and education.
The Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, and the University of California-San Diego (UCSD) this month reached a significant milestone in its 37-year history. The 50,000th molecule structure was released into its archive, joining other structures vital to pharmacology, bioinformatics and education.
Biochemistry
Source: EurekAlert
Posted on: Tuesday, Apr 08, 2008, 12:17pm
Rating: | Views: 1178 | Comments: 0
Source: EurekAlert
Posted on: Tuesday, Apr 08, 2008, 12:17pm
Rating: | Views: 1178 | Comments: 0
Synthetic molecules may be less expensive alternative to therapeutic antibodies
Researchers at UT Southwestern Medical Center have developed a simple and inexpensive method to screen small synthetic molecules and pull out a handful that might treat cancer and other diseases less expensively than current methods.
Researchers at UT Southwestern Medical Center have developed a simple and inexpensive method to screen small synthetic molecules and pull out a handful that might treat cancer and other diseases less expensively than current methods.
Biochemistry
Source: EurekAlert
Posted on: Friday, Apr 04, 2008, 11:49am
Rating: | Views: 1226 | Comments: 0
Source: EurekAlert
Posted on: Friday, Apr 04, 2008, 11:49am
Rating: | Views: 1226 | Comments: 0
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