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Raised antibody levels linked to greater long term risk of rheumatoid arthritis 
Men and women with raised levels of an antibody known as rheumatoid factor in their blood have up to a 26-fold greater long term risk of developing rheumatoid arthritis, finds a study published on bmj.com today.
Men and women with raised levels of an antibody known as rheumatoid factor in their blood have up to a 26-fold greater long term risk of developing rheumatoid arthritis, finds a study published on bmj.com today.
Immunology
Source: BMJ-British Medical Journal
Posted on: Friday, Sep 07, 2012, 2:15pm
Rating: | Views: 1603 | Comments: 0
Source: BMJ-British Medical Journal
Posted on: Friday, Sep 07, 2012, 2:15pm
Rating: | Views: 1603 | Comments: 0
Immune cell death safeguards against autoimmune disease
Researchers at the Walter and Eliza Hall Institute have discovered that a pair of molecules work together to kill so-called 'self-reactive' immune cells that are programmed to attack the body's own organs. The finding is helping to explain how autoimmune diseases develop.
Researchers at the Walter and Eliza Hall Institute have discovered that a pair of molecules work together to kill so-called 'self-reactive' immune cells that are programmed to attack the body's own organs. The finding is helping to explain how autoimmune diseases develop.
Immunology
Source: Walter and Eliza Hall Institute
Posted on: Friday, Sep 07, 2012, 10:30am
Rating: | Views: 1256 | Comments: 0
Source: Walter and Eliza Hall Institute
Posted on: Friday, Sep 07, 2012, 10:30am
Rating: | Views: 1256 | Comments: 0
New genetic clues to why most bone marrow transplant patients develop graft-versus-host disease
A team of scientists led by a bone marrow transplant researcher at Fred Hutchinson Cancer Research Center has shed new light on why most bone marrow transplant patients who receive tissue-matched cells from unrelated donors still suffer acute graft-versus-host disease (GVHD). The answer appears to lie in the discovery of previously undetected genetic differences in the DNA of patients a
A team of scientists led by a bone marrow transplant researcher at Fred Hutchinson Cancer Research Center has shed new light on why most bone marrow transplant patients who receive tissue-matched cells from unrelated donors still suffer acute graft-versus-host disease (GVHD). The answer appears to lie in the discovery of previously undetected genetic differences in the DNA of patients a
Immunology
Source: Fred Hutchinson Cancer Research Center
Posted on: Wednesday, Sep 05, 2012, 10:00am
Rating: | Views: 1190 | Comments: 0
Source: Fred Hutchinson Cancer Research Center
Posted on: Wednesday, Sep 05, 2012, 10:00am
Rating: | Views: 1190 | Comments: 0
Researchers discover missing link between stem cells and immune system
UCLA researchers have discovered a type of cell that is the "missing link" between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.
UCLA researchers have discovered a type of cell that is the "missing link" between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.
Immunology
Source: University of California - Los Angeles Health Sciences
Posted on: Tuesday, Sep 04, 2012, 10:45am
Rating: | Views: 1324 | Comments: 0
Source: University of California - Los Angeles Health Sciences
Posted on: Tuesday, Sep 04, 2012, 10:45am
Rating: | Views: 1324 | Comments: 0
Monogamy and the immune system
In the foothills of the Santa Cruz Mountains two closely related species of mice share a habitat and a genetic lineage, but have very different social lives. The California mouse (Peromyscus californicus) is characterized by a lifetime of monogamy; the deer mouse (Peromyscus maniculatus) is sexually promiscuous.
In the foothills of the Santa Cruz Mountains two closely related species of mice share a habitat and a genetic lineage, but have very different social lives. The California mouse (Peromyscus californicus) is characterized by a lifetime of monogamy; the deer mouse (Peromyscus maniculatus) is sexually promiscuous.
Immunology
Source: University of Texas at Austin, Texas Advanced Computing Center
Posted on: Friday, Aug 31, 2012, 2:00pm
Rating: | Views: 1723 | Comments: 0
Source: University of Texas at Austin, Texas Advanced Computing Center
Posted on: Friday, Aug 31, 2012, 2:00pm
Rating: | Views: 1723 | Comments: 0
Early activation of immune response could lead to better vaccines
Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a new "first response" mechanism that the immune system uses to respond to infection. The findings challenge the current understanding of immunity and could lead to new strategies for boosting effectiveness of all vaccines. The study, conducted in mice, published online today in
Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a new "first response" mechanism that the immune system uses to respond to infection. The findings challenge the current understanding of immunity and could lead to new strategies for boosting effectiveness of all vaccines. The study, conducted in mice, published online today in
Immunology
Source: Albert Einstein College of Medicine
Posted on: Friday, Aug 31, 2012, 1:30pm
Rating: | Views: 1253 | Comments: 0
Source: Albert Einstein College of Medicine
Posted on: Friday, Aug 31, 2012, 1:30pm
Rating: | Views: 1253 | Comments: 0
Researchers identify unforeseen regulation of the anti-bacterial immune response
New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them. The publication title is "Nitric oxide inhibits t
New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them. The publication title is "Nitric oxide inhibits t
Microbiology
Source: Trudeau Institute
Posted on: Wednesday, Aug 29, 2012, 11:00am
Rating: | Views: 1179 | Comments: 0
Source: Trudeau Institute
Posted on: Wednesday, Aug 29, 2012, 11:00am
Rating: | Views: 1179 | Comments: 0
How a virus might make you diabetic later in life
Cytomegalovirus (CMV) is one of the viruses that most infected people carry without ill effects. Once infected you are infected for life and, although it normally is dormant, it can become active again at any point in time. New research published in BioMed Central's open access journal Immunity and Ageing shows that CMV infection is a significant risk factor for the type 2 diabetes in the e
Cytomegalovirus (CMV) is one of the viruses that most infected people carry without ill effects. Once infected you are infected for life and, although it normally is dormant, it can become active again at any point in time. New research published in BioMed Central's open access journal Immunity and Ageing shows that CMV infection is a significant risk factor for the type 2 diabetes in the e
Immunology
Source: BioMed Central
Posted on: Tuesday, Aug 28, 2012, 5:00pm
Rating: | Views: 1614 | Comments: 0
Source: BioMed Central
Posted on: Tuesday, Aug 28, 2012, 5:00pm
Rating: | Views: 1614 | Comments: 0
Compound discovered that boosts effect of vaccines against HIV and flu
Oxford University scientists have discovered a compound that greatly boosts the effect of vaccines against viruses like flu, HIV and herpes in mice.
Oxford University scientists have discovered a compound that greatly boosts the effect of vaccines against viruses like flu, HIV and herpes in mice.
Immunology
Source: University of Oxford
Posted on: Monday, Aug 27, 2012, 12:15pm
Rating: | Views: 1185 | Comments: 0
Source: University of Oxford
Posted on: Monday, Aug 27, 2012, 12:15pm
Rating: | Views: 1185 | Comments: 0
Dual action polyclonal antibody may offer more effective, safer protection against osteoporosis
A new study suggests that a polyclonal antibody that blocks follicle-stimulating hormone (FSH) in mice without ovaries might offer a more effective way to prevent or arrest osteoporosis than currently available treatments.
A new study suggests that a polyclonal antibody that blocks follicle-stimulating hormone (FSH) in mice without ovaries might offer a more effective way to prevent or arrest osteoporosis than currently available treatments.
Immunology
Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
Posted on: Tuesday, Aug 21, 2012, 10:45am
Rating: | Views: 1415 | Comments: 0
Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
Posted on: Tuesday, Aug 21, 2012, 10:45am
Rating: | Views: 1415 | Comments: 0
Scientists find an important molecular trigger for wound-healing
Scientists at The Scripps Research Institute have made a breakthrough in understanding a class of cells that help wounds in skin and other epithelial tissues heal, uncovering a molecular mechanism that pushes the body into wound-repair mode.
Scientists at The Scripps Research Institute have made a breakthrough in understanding a class of cells that help wounds in skin and other epithelial tissues heal, uncovering a molecular mechanism that pushes the body into wound-repair mode.
Immunology
Source: Scripps Research Institute
Posted on: Friday, Aug 17, 2012, 12:45pm
Rating: | Views: 1279 | Comments: 0
Source: Scripps Research Institute
Posted on: Friday, Aug 17, 2012, 12:45pm
Rating: | Views: 1279 | Comments: 0
B cell survival holds key to chronic graft vs. host disease
Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime, and ultimately affect their long-term survival.
Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime, and ultimately affect their long-term survival.
Immunology
Source: University of North Carolina Health Care
Posted on: Friday, Aug 17, 2012, 10:30am
Rating: | Views: 1223 | Comments: 0
Source: University of North Carolina Health Care
Posted on: Friday, Aug 17, 2012, 10:30am
Rating: | Views: 1223 | Comments: 0
Duke scientists discover genetic material in blood cells that may affect malaria parasites
Researchers at Duke University Medical Center may finally have discovered why people with sickle cell disease get milder cases of malaria than individuals who have normal red blood cells.
Researchers at Duke University Medical Center may finally have discovered why people with sickle cell disease get milder cases of malaria than individuals who have normal red blood cells.
Immunology
Source: Duke University Medical Center
Posted on: Thursday, Aug 16, 2012, 11:45am
Rating: | Views: 1156 | Comments: 0
Source: Duke University Medical Center
Posted on: Thursday, Aug 16, 2012, 11:45am
Rating: | Views: 1156 | Comments: 0
Vaccine targets malignant brain cancer antigens, significantly lengthens survival
An experimental immune-based therapy more than doubled median survival of patients diagnosed with the most aggressive malignant brain tumor, Cedars-Sinai Medical Center researchers reported in Cancer Immunology, Immunotherapy, published online Aug. 3.
An experimental immune-based therapy more than doubled median survival of patients diagnosed with the most aggressive malignant brain tumor, Cedars-Sinai Medical Center researchers reported in Cancer Immunology, Immunotherapy, published online Aug. 3.
Cancer
Source: Cedars-Sinai Medical Center
Posted on: Thursday, Aug 16, 2012, 8:30am
Rating: | Views: 1286 | Comments: 0
Source: Cedars-Sinai Medical Center
Posted on: Thursday, Aug 16, 2012, 8:30am
Rating: | Views: 1286 | Comments: 0
Video: A vaccine for heart disease? Discovery points up this possibility
Most people probably know that heart disease remains the nation's No. 1 killer. But what many may be surprised to learn is that cholesterol has a major accomplice in causing dangerous arterial plaque buildup that can trigger a heart attack. The culprit? Inflammatory cells produced by the immune system.
Most people probably know that heart disease remains the nation's No. 1 killer. But what many may be surprised to learn is that cholesterol has a major accomplice in causing dangerous arterial plaque buildup that can trigger a heart attack. The culprit? Inflammatory cells produced by the immune system.
Immunology
Source: La Jolla Institute for Allergy and Immunology
Posted on: Wednesday, Aug 15, 2012, 8:30am
Rating: | Views: 1731 | Comments: 0
Source: La Jolla Institute for Allergy and Immunology
Posted on: Wednesday, Aug 15, 2012, 8:30am
Rating: | Views: 1731 | Comments: 0
Little chance for ebola vaccine
Scientists involved in ebola research tell the BBC that a commercial vaccine to prevent the onset of the deadly infection may never be developed.
Scientists involved in ebola research tell the BBC that a commercial vaccine to prevent the onset of the deadly infection may never be developed.
Immunology
Source: BBC News
Posted on: Wednesday, Aug 15, 2012, 8:07am
Rating: | Views: 1113 | Comments: 0
Source: BBC News
Posted on: Wednesday, Aug 15, 2012, 8:07am
Rating: | Views: 1113 | Comments: 0
Team creates new view of body's infection response
A new 3-D view of the body's response to infection – and the ability to identify proteins involved in the response – could point to novel biomarkers and therapeutic agents for infectious diseases.
A new 3-D view of the body's response to infection – and the ability to identify proteins involved in the response – could point to novel biomarkers and therapeutic agents for infectious diseases.
Immunology
Source: Vanderbilt University Medical Center
Posted on: Monday, Aug 13, 2012, 12:30pm
Rating: | Views: 1163 | Comments: 0
Source: Vanderbilt University Medical Center
Posted on: Monday, Aug 13, 2012, 12:30pm
Rating: | Views: 1163 | Comments: 0
Scientists describe antibodies that protect against large variety of flu viruses
A team led by scientists at The Scripps Research Institute and Crucell Vaccine Institute in the Netherlands describes three human antibodies that provide broad protection against Influenza B virus strains. The same team had previously reported finding broadly neutralizing antibodies against Influenza A strains.
A team led by scientists at The Scripps Research Institute and Crucell Vaccine Institute in the Netherlands describes three human antibodies that provide broad protection against Influenza B virus strains. The same team had previously reported finding broadly neutralizing antibodies against Influenza A strains.
Immunology
Source: Scripps Research Institute
Posted on: Friday, Aug 10, 2012, 2:15pm
Rating: | Views: 1350 | Comments: 0
Source: Scripps Research Institute
Posted on: Friday, Aug 10, 2012, 2:15pm
Rating: | Views: 1350 | Comments: 0
Chronic exposure to staph bacteria may be risk factor for lupus, Mayo study finds
Chronic exposure to even small amounts of staph bacteria could be a risk factor for the chronic inflammatory disease lupus, Mayo Clinic research shows. Staph, short for Staphylococcus aureus, is a germ commonly found on the skin or in the nose, sometimes causing infections.
Chronic exposure to even small amounts of staph bacteria could be a risk factor for the chronic inflammatory disease lupus, Mayo Clinic research shows. Staph, short for Staphylococcus aureus, is a germ commonly found on the skin or in the nose, sometimes causing infections.
Immunology
Source: Mayo Clinic
Posted on: Friday, Aug 10, 2012, 11:15am
Rating: | Views: 1321 | Comments: 0
Source: Mayo Clinic
Posted on: Friday, Aug 10, 2012, 11:15am
Rating: | Views: 1321 | Comments: 0
Test vaccine successfully protects monkeys from Nipah virus
Researchers have successfully tested in monkeys a vaccine against Nipah virus, a human pathogen that emerged in 1998 during a large outbreak of infection and disease among pigs and pig farmers in Southeast Asia. This latest advance builds upon earlier work by the scientists, who found that the same vaccine can protect cats from Nipah virus.
Researchers have successfully tested in monkeys a vaccine against Nipah virus, a human pathogen that emerged in 1998 during a large outbreak of infection and disease among pigs and pig farmers in Southeast Asia. This latest advance builds upon earlier work by the scientists, who found that the same vaccine can protect cats from Nipah virus.
Immunology
Source: NIH/National Institute of Allergy and Infectious Diseases
Posted on: Friday, Aug 10, 2012, 11:00am
Rating: | Views: 1183 | Comments: 0
Source: NIH/National Institute of Allergy and Infectious Diseases
Posted on: Friday, Aug 10, 2012, 11:00am
Rating: | Views: 1183 | Comments: 0
White blood cells mediate insulin resistance
Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance – the central characteristic of type 2 diabetes, which afflicts an estimated 26 million Americans.
Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance – the central characteristic of type 2 diabetes, which afflicts an estimated 26 million Americans.
Immunology
Source: University of California - San Diego
Posted on: Monday, Aug 06, 2012, 8:15am
Rating: | Views: 1390 | Comments: 0
Source: University of California - San Diego
Posted on: Monday, Aug 06, 2012, 8:15am
Rating: | Views: 1390 | Comments: 0
Unexpected variation in immune genes poses difficulties for transplantation
Human HLA genes – the genes that allow our immune system to tell the difference between our own cells and foreign invaders – are evolving much more rapidly than previously thought, according to an article online on August 3rd in Trends in Genetics. The resulting degree of variation improves our ability to fight off disease, but could also present challenges to current worldwide efforts aime
Human HLA genes – the genes that allow our immune system to tell the difference between our own cells and foreign invaders – are evolving much more rapidly than previously thought, according to an article online on August 3rd in Trends in Genetics. The resulting degree of variation improves our ability to fight off disease, but could also present challenges to current worldwide efforts aime
Immunology
Source: Cell Press
Posted on: Saturday, Aug 04, 2012, 8:15am
Rating: | Views: 1377 | Comments: 0
Source: Cell Press
Posted on: Saturday, Aug 04, 2012, 8:15am
Rating: | Views: 1377 | Comments: 0
Infants exposed to specific molds have higher asthma risk
In the United States, one in 10 children suffers from asthma but the potential environmental factors contributing to the disease are not well known. Cincinnati-based researchers now report new evidence that exposure to three types of mold during infancy may have a direct link to asthma development during childhood.
In the United States, one in 10 children suffers from asthma but the potential environmental factors contributing to the disease are not well known. Cincinnati-based researchers now report new evidence that exposure to three types of mold during infancy may have a direct link to asthma development during childhood.
Immunology
Source: University of Cincinnati Academic Health Center
Posted on: Friday, Aug 03, 2012, 8:45am
Rating: | Views: 1658 | Comments: 0
Source: University of Cincinnati Academic Health Center
Posted on: Friday, Aug 03, 2012, 8:45am
Rating: | Views: 1658 | Comments: 0
HIV-infected T cells help transport the virus throughout the body
A new study has discovered one more way the human immunodeficiency virus (HIV) exploits the immune system. Not only does HIV infect and destroy CD4-positive helper T cells – which normally direct and support the infection-fighting activities of other immune cells – the virus also appears to use those cells to travel through the body and infect other CD4 T cells. The study from Massachusetts Gene
A new study has discovered one more way the human immunodeficiency virus (HIV) exploits the immune system. Not only does HIV infect and destroy CD4-positive helper T cells – which normally direct and support the infection-fighting activities of other immune cells – the virus also appears to use those cells to travel through the body and infect other CD4 T cells. The study from Massachusetts Gene
Immunology
Source: Massachusetts General Hospital
Posted on: Thursday, Aug 02, 2012, 12:45pm
Rating: | Views: 1176 | Comments: 0
Source: Massachusetts General Hospital
Posted on: Thursday, Aug 02, 2012, 12:45pm
Rating: | Views: 1176 | Comments: 0
Research team finds possible clue to progression of MS
Wayne State University School of Medicine researchers, working with colleagues in Canada, have found that one or more substances produced by a type of immune cell in people with multiple sclerosis (MS) may play a role in the disease's progression. The finding could lead to new targeted therapies for MS treatment.
Wayne State University School of Medicine researchers, working with colleagues in Canada, have found that one or more substances produced by a type of immune cell in people with multiple sclerosis (MS) may play a role in the disease's progression. The finding could lead to new targeted therapies for MS treatment.
Immunology
Source: Wayne State University - Office of the Vice President for Research
Posted on: Wednesday, Aug 01, 2012, 1:15pm
Rating: | Views: 1181 | Comments: 0
Source: Wayne State University - Office of the Vice President for Research
Posted on: Wednesday, Aug 01, 2012, 1:15pm
Rating: | Views: 1181 | Comments: 0
Autoantibodies damage blood vessels in the brain
The presence of specific autoantibodies of the immune system is associated with blood vessel damage in the brain. These findings were made by Marion Bimmler, a graduate engineer of medical laboratory diagnostics at the Max Delbrück Center for Molecular Medicine Berlin-Buch and Dr. Peter Karczewski of the biotech company E.R.D.E.-AAK-Diagnostik GmbH in studies on a rat model. The researchers' resul
The presence of specific autoantibodies of the immune system is associated with blood vessel damage in the brain. These findings were made by Marion Bimmler, a graduate engineer of medical laboratory diagnostics at the Max Delbrück Center for Molecular Medicine Berlin-Buch and Dr. Peter Karczewski of the biotech company E.R.D.E.-AAK-Diagnostik GmbH in studies on a rat model. The researchers' resul
Immunology
Source: Helmholtz Association of German Research Centres
Posted on: Wednesday, Aug 01, 2012, 10:30am
Rating: | Views: 1141 | Comments: 0
Source: Helmholtz Association of German Research Centres
Posted on: Wednesday, Aug 01, 2012, 10:30am
Rating: | Views: 1141 | Comments: 0
Discovery of new white blood cell reveals target for better vaccine design
Researchers in Newcastle and Singapore have identified a new type of white blood cell which activates a killing immune response to an external source – providing a new potential target for vaccines for conditions such as cancer or Hepatitis B.
Researchers in Newcastle and Singapore have identified a new type of white blood cell which activates a killing immune response to an external source – providing a new potential target for vaccines for conditions such as cancer or Hepatitis B.
Immunology
Source: Newcastle University
Posted on: Monday, Jul 30, 2012, 8:45am
Rating: | Views: 1254 | Comments: 0
Source: Newcastle University
Posted on: Monday, Jul 30, 2012, 8:45am
Rating: | Views: 1254 | Comments: 0
Scientists explore new class of synthetic vaccines
In a quest to make safer and more effective vaccines, scientists at the Biodesign InstituteÒ at Arizona State University have turned to a promising field called DNA nanotechnology to make an entirely new class of synthetic vaccines.
In a quest to make safer and more effective vaccines, scientists at the Biodesign InstituteÒ at Arizona State University have turned to a promising field called DNA nanotechnology to make an entirely new class of synthetic vaccines.
Immunology
Source: Arizona State University
Posted on: Wednesday, Jul 25, 2012, 2:30pm
Rating: | Views: 1215 | Comments: 0
Source: Arizona State University
Posted on: Wednesday, Jul 25, 2012, 2:30pm
Rating: | Views: 1215 | Comments: 0
Researchers discover new target for vaccine development in abundant immune cells
White blood cells called neutrophils, which are the first line of defense against infection, play an unexpected role by boosting antibody production, according to research led by Mount Sinai School of Medicine. The findings suggest neutrophils have multiple roles within the immune system and function at levels previously unknown to the scientific community. The research, published in Nature Imm
White blood cells called neutrophils, which are the first line of defense against infection, play an unexpected role by boosting antibody production, according to research led by Mount Sinai School of Medicine. The findings suggest neutrophils have multiple roles within the immune system and function at levels previously unknown to the scientific community. The research, published in Nature Imm
Immunology
Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
Posted on: Wednesday, Jul 25, 2012, 12:30pm
Rating: | Views: 1347 | Comments: 0
Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
Posted on: Wednesday, Jul 25, 2012, 12:30pm
Rating: | Views: 1347 | Comments: 0
Oral immunotherapy shows promise as treatment for egg allergy
Giving children and adolescents with egg allergy small but increasing daily doses of egg white powder holds the possibility of developing into a way to enable some of them to eat egg-containing foods without having allergic reactions, according to a study supported by the National Institutes of Health. The study results will appear online in the July 19th issue of the New England Journal of Med
Giving children and adolescents with egg allergy small but increasing daily doses of egg white powder holds the possibility of developing into a way to enable some of them to eat egg-containing foods without having allergic reactions, according to a study supported by the National Institutes of Health. The study results will appear online in the July 19th issue of the New England Journal of Med
Immunology
Source: NIH/National Institute of Allergy and Infectious Diseases
Posted on: Thursday, Jul 19, 2012, 2:00pm
Rating: | Views: 1797 | Comments: 0
Source: NIH/National Institute of Allergy and Infectious Diseases
Posted on: Thursday, Jul 19, 2012, 2:00pm
Rating: | Views: 1797 | Comments: 0
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