Pushing the boundaries of transcription Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cel
Discovery of a gene that controls 3 different diseases An international research consortium led by the Universitat Autònoma de Barcelona (UAB), the CIBERER and the University of Wurzburg (Germany) has discovered a gene that can cause three totally different diseases, depending on how it is altered.
Molecular Biology Source: Universitat Autonoma de Barcelona
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Friday, Apr 26, 2013, 12:30pm Rating: | Views: 1737 | Comments: 0
Inhibiting enzymes in the cell may lead to development and proliferation of cancer cells Blocking certain enzymes in the cell may prevent cancer cell division and growth, according to new findings from researchers at the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. The discovery is published in the April 25, 2013 issue of the journal Molecular Cell.
Cancer Source: The Mount Sinai Hospital / Mount Sinai School of Medicine
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Friday, Apr 26, 2013, 12:15pm Rating: | Views: 1530 | Comments: 0
Link between inherited endocrine tumor syndrome and much-studied cell pathway A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1). Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin.
Molecular Biology Source: University of Pennsylvania School of Medicine
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Thursday, Apr 25, 2013, 1:30pm Rating: | Views: 1519 | Comments: 0
Epigenetic changes shed light on biological mechanism of autism Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. The study, published in Molecular Psychiatry, is the largest of its kind and may shed light on the biological mechanism by which environmental influences regulate the activity of certain genes and
Neuroscience Source: King's College London
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Tuesday, Apr 23, 2013, 4:30pm Rating: | Views: 1292 | Comments: 0
Molecular Biology Source: Scripps Research Institute
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Tuesday, Apr 23, 2013, 11:15am Rating: | Views: 1398 | Comments: 0
New light shed on early stage Alzheimer's disease The disrupted metabolism of sugar, fat and calcium is part of the process that causes the death of neurons in Alzheimer's disease. Researchers from Karolinska Institutet in Sweden have now shown, for the first time, how important parts of the nerve cell that are involved in the cell's energy metabolism operate in the early stages of the disease. These somewhat surprising results shed new light on
A check on tension Ludwig researchers Arshad Desai and Christopher Campbell, a post-doctoral fellow in his laboratory, were conducting an experiment to parse the molecular details of cell division about three years ago, when they engineered a mutant yeast cell as a control that, in theory, had no chance of surviving. Apparently unaware of this, the mutant thrived.
Molecular Biology Source: Ludwig Institute for Cancer Research
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Monday, Apr 22, 2013, 2:45pm Rating: | Views: 1482 | Comments: 0
Same protein that fires up cancer-promoting Erk also blocks its activation A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology.
Molecular Biology Source: University of Texas M. D. Anderson Cancer Center
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Monday, Apr 22, 2013, 1:15pm Rating: | Views: 1408 | Comments: 0
Random walks on DNA Scientists have revealed how a bacterial enzyme has evolved an energy-efficient method to move long distances along DNA. The findings, published in Science, present further insight into the coupling of chemical and mechanical energy by a class of enzymes called helicases, a widely-distributed group of proteins, which in human cells are implicated in some cancers.
Molecular Biology Source: University of Bristol
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Monday, Apr 22, 2013, 10:30am Rating: | Views: 1600 | Comments: 0
A surprising new function for small RNAs in evolution It has long been known that certain proteins, known as transcription factors, directly control the way in which information is read from DNA. As a result, it is widely believed that changes in genes encoding such proteins underlie the mechanisms responsible for evolutionary adaptation. The idea that small RNA molecules, so-called microRNAs, may play an important part in evolutionary changes to a
Molecular Biology Source: University of Veterinary Medicine -- Vienna
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Friday, Apr 19, 2013, 2:15pm Rating: | Views: 1952 | Comments: 0
Researchers discover that stem cell senescence drives aging Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor or stem cells -- important for repair and regeneration of skeletal muscle and maintenance of healthy fat tissue -- are subject to cellular senescence,
Molecular Biology Source: Mayo Clinic
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Friday, Apr 19, 2013, 12:00pm Rating: | Views: 3633 | Comments: 0
New stem cell-based screen reveals promising drug for Lou Gehrig's disease Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a fatal disease that causes motor neurons, which are responsible for controlling muscles, to die. A study published by Cell Press on April 18th in Cell Stem Cell has revealed a novel stem-cell-based approach to screen for effective treatments, which are sorely lacking. Applying this method to motor neurons derived fro
Discovery may help prevent HIV 'reservoirs' from forming Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the protein that blocks HIV-1 from multiplying in white blood cells is regulated. HIV-1 is the virus that causes AIDS, and the discovery could lead to novel approaches for addressing HIV-1 "in hiding" – namely eliminating reservoirs of HIV-1 that persist in patients undergoin
Molecular Biology Source: Albert Einstein College of Medicine
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Thursday, Apr 18, 2013, 1:30pm Rating: | Views: 1448 | Comments: 0
Hop, skip or jump? Study says no to all of the above Osteoarthritis, which affects at least 20 percent of adults in the United States, leads to deterioration of cartilage, the rubbery tissue that prevents bones from rubbing together. By studying the molecular properties of cartilage, MIT engineers have now discovered how the earliest stages of arthritis make the tissue more susceptible to damage from physical activities such as runn
Health Source: Massachusetts Institute of Technology
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Thursday, Apr 18, 2013, 12:30pm Rating: | Views: 1357 | Comments: 0
Scientists reveal natural process that blocks viruses The human body has the ability to ward off viruses by activating a naturally occurring protein at the cellular level, setting off a chain reaction that disrupts the levels of cholesterol required in cell membranes to enable viruses to enter cells. The findings, discovered by researchers in molecular microbiology and immunology at the Keck School of Medicine of USC, hold promise for the development
Immunology Source: University of Southern California - Health Sciences
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Thursday, Apr 18, 2013, 12:00pm Rating: | Views: 1856 | Comments: 0
Recipe for large numbers of stem cells requires only one ingredient Stem cells and tissue-specific cells can be grown in abundance from mature mammalian cells simply by blocking a certain membrane protein, according to scientists at the University of Pittsburgh School of Medicine and the National Institutes of Health (NIH). Their experiments, reported today in Scientific Reports, also show that the process doesn't require other kinds of cells or agents to a
Molecular Biology Source: University of Pittsburgh Schools of the Health Sciences
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Wednesday, Apr 17, 2013, 2:15pm Rating: | Views: 1432 | Comments: 0
Molecular Biology Source: University of North Carolina Health Care
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Wednesday, Apr 17, 2013, 11:00am Rating: | Views: 1496 | Comments: 0
Molecular signaling in early placenta formation gives clues to causes of pregnancy complications Understanding the molecular control of placenta formation, the organ which enables fetal growth, is critical in diagnosing and treating related pregnancy complications. A group of scientists at the Chinese Academy of Sciences, Beijing, China, and the University of Calgary, Canada has revealed a molecular feedback loop that governs the earliest steps of placenta formation in mice, which is known to
Development Source: Public Library of Science
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Wednesday, Apr 17, 2013, 8:30am Rating: | Views: 1476 | Comments: 0
Cancer cell metabolism kills ATP is the main energy currency of cells and one might expect that not only contracting muscle, but also uncontrollably dividing cancer cells would have a high demand for ATP. However, for some reason cancer cells have re-programmed their metabolic engines to produce less ATP. The phenomenon, known as Warburg effect, is typical for cancer cells and the mechanism behind is believed to benefit cance
Molecular Biology Source: University of Helsinki
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Tuesday, Apr 16, 2013, 11:00am Rating: | Views: 1670 | Comments: 0
The tulip tree reveals mitochondrial genome of ancestral flowering plant The extraordinary level of conservation of the tulip tree (Liriodendron tulipifera) mitochondrial genome has redefined our interpretation of evolution of the angiosperms (flowering plants), finds research in biomed Central's open access journal BMC Biology. This beautiful 'molecular fossil' has a remarkably slow mutation rate meaning that its mitochondrial genome has remained largely
Plant Biology Source: BioMed Central
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Monday, Apr 15, 2013, 1:15pm Rating: | Views: 1932 | Comments: 0
Health Source: University of Iowa Health Care
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Friday, Apr 12, 2013, 4:15pm Rating: | Views: 1643 | Comments: 0
Molecular techniques are man's new best friend in pet obesity research According to the World Health Organization, more than two-thirds of Americans are overweight or obese. And it's not just humans who are packing on the pounds. Our furry companions are plagued by an obesity epidemic of their own. More than 50 percent of the dogs and cats in the United States are overweight or obese.
Health Source: University of Illinois at Urbana-Champaign
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Friday, Apr 12, 2013, 2:15pm Rating: | Views: 1487 | Comments: 0
Healing by the clock Circadian rhythms keep time for all living things, from regulating when plants open their flowers to foiling people when they try to beat jet lag. Day-night cycles are controlled through ancient biological mechanisms, evolutionarily speaking, so in essence, a human has the same internal clock as a fly does.
Molecular Biology Source: Harvard Medical School
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Friday, Apr 12, 2013, 1:45pm Rating: | Views: 1382 | Comments: 0
Molecular Biology Source: University of Washington
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Friday, Apr 12, 2013, 1:15pm Rating: | Views: 1477 | Comments: 0
Genetic master controls expose cancers' Achilles' heel In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state and identity. Healthy cells employ these super-enhancers to control genes responsible for cellular functions and developmental transitions—
Molecular Biology Source: Whitehead Institute for Biomedical Research
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Friday, Apr 12, 2013, 12:45pm Rating: | Views: 1461 | Comments: 0
Researchers find new way to clear cholesterol from the blood Researchers at the University of Michigan have identified a new potential therapeutic target for lowering cholesterol that could be an alternative or complementary therapy to statins.
Molecular Biology Source: University of Michigan
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Thursday, Apr 11, 2013, 4:15pm Rating: | Views: 3139 | Comments: 0
Research reveals Rx target for HPV, Hep C and related cancers New discoveries by a team of scientists at LSU Health Sciences Center New Orleans for the first time reveal the inner workings of a master regulator that controls functions as diverse as the ability of nerve cells to "rewire" themselves in response to external stimuli and the mechanism by which certain viruses hijack normal cellular processes to facilitate their replication that
Molecular Biology Source: Louisiana State University Health Sciences Center
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Thursday, Apr 11, 2013, 12:45pm Rating: | Views: 1408 | Comments: 0
Video: Hydrogel process creates transparent brain Combining neuroscience and chemical engineering, researchers at Stanford University have developed a process that renders a mouse brain transparent. The postmortem brain remains whole — not sliced or sectioned in any way — with its three-dimensional complexity of fine wiring and molecular structures completely intact and able to be measured and probed at will with visible light
Neuroscience Source: Stanford University Medical Center
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Thursday, Apr 11, 2013, 11:15am Rating: | Views: 1899 | Comments: 0
Producing new neurons under all circumstances: A challenge that is just a mouse away These results incentivise the development of targeted therapies enabling improved neurone production to alleviate cognitive decline in the elderly and reduce the cerebral lesions caused by radiotherapy.
The research is published in the journal EMBO Molecular Medicine.
Neuroscience Source: INSERM (Institut national de la sant� et de la recherche m�dicale)
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Wednesday, Apr 10, 2013, 1:45pm Rating: | Views: 5809 | Comments: 0